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Chemistry
Organic Building Blocks
Bromides
Methyl 3-bromo-5-(cyanomethyl)benzoate
Chemistry
Organic Building Blocks
Bromides
Nitriles Benzene Compounds

[ CAS No. 878741-84-5 ]

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Cat. No.: {[proInfo.prAm]}
3d Animation Molecule Structure of 878741-84-5
Chemical Structure| 878741-84-5
Chemical Structure| 878741-84-5
Structure of 878741-84-5 * Storage: {[proInfo.prStorage]}
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Quality Control of [ 878741-84-5 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 878741-84-5 ]

SDS Specification
Alternatived Products of [ 878741-84-5 ]

Product Details of [ 878741-84-5 ]

CAS No. :878741-84-5 MDL No. :MFCD18378610
Formula : C10H8BrNO2 Boiling Point : -
Linear Structure Formula :- InChI Key :HHMMDHGCCRYVID-UHFFFAOYSA-N
M.W :254.08 Pubchem ID :68955467
Synonyms :

Calculated chemistry of [ 878741-84-5 ]

Physicochemical Properties

Num. heavy atoms : 14
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.2
Num. rotatable bonds : 3
Num. H-bond acceptors : 3.0
Num. H-bond donors : 0.0
Molar Refractivity : 54.94
TPSA : 50.09 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.34 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.22
Log Po/w (XLOGP3) : 2.12
Log Po/w (WLOGP) : 2.3
Log Po/w (MLOGP) : 2.29
Log Po/w (SILICOS-IT) : 2.73
Consensus Log Po/w : 2.33

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.87
Solubility : 0.343 mg/ml ; 0.00135 mol/l
Class : Soluble
Log S (Ali) : -2.8
Solubility : 0.4 mg/ml ; 0.00157 mol/l
Class : Soluble
Log S (SILICOS-IT) : -3.82
Solubility : 0.0384 mg/ml ; 0.000151 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 0.0
Synthetic accessibility : 1.85

Safety of [ 878741-84-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:N/A
Hazard Statements:H302-H312-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 878741-84-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 878741-84-5 ]

[ 878741-84-5 ] Synthesis Path-Downstream   1~35

  • 2
  • [ 878741-84-5 ]
  • [ 74-88-4 ]
  • [ 878742-12-2 ]
YieldReaction ConditionsOperation in experiment
95% Stage #1: methyl 3-bromo-5-(cyanomethyl)benzoate With sodium hydride In dimethyl sulfoxide at 20℃; Stage #2: methyl iodide In dimethyl sulfoxide at 0 - 25℃; for 12h; 131 Method 131; Methyl 3 -bromo-5 -( 1 -cyano- 1 -methy lethy Dbenzoate; A solution of methyl 3-bromo-5-(cyanomethyl)benzoate (Method 30; 600 mg, 2.36 mmol) in anhydrous DMSO (12 ml) was treated with sodium hydride (60%, 284 mg, 7.09 mmol). Iodomethane (0.882 ml, 14.17 mmol) was then added dropwise at 0 °C. The reaction mixture was stirred at 25 °C for 12 h. The reaction mixture was then quenched with water (200 ml) and extracted with EtOAc. The combined organics were dried and concentrated under reduced pressure. The crude product was purified by column chromatography utilizing an ISCO system (hexane-EtOAc) to give 635 mg (95%) of a clear oil; NMR (300 MHz): 7.92 (s, IH), 7.83 (s, IH), 7.55 (s, IH), 3.94 (s, 3H), 1.76 (s, 6H).
Reference： [1]Current Patent Assignee: DAKIN; LYNE PAUL DERMOT; ASTRAZENECA PLC - WO2006/40568, 2006, A1 Location in patent: Page/Page column 83
  • 3
  • [ 478375-40-5 ]
  • [ 878741-84-5 ]
Reference： [1]Patent: US2016/158377,2016,A1
[2]Patent: WO2016/94509,2016,A1
[3]Patent: WO2017/214458,2017,A2
  • 4
  • [ 877624-40-3 ]
  • [ 10442-39-4 ]
  • [ 878741-84-5 ]
YieldReaction ConditionsOperation in experiment
In acetonitrile; at 70℃; tetrabutylammonium cyanide (50 g) was added to Example 1.21.1 (67.1 g) in 300 mL acetonitrile, and the mixture was heated to 70 C. overnight. The mixture was cooled, poured into diethyl ether, and rinsed with water and brine. The mixture was concentrated and chromatographed on silica gel using 2-20% ethyl acetate in heptane to give the title compound.
In acetonitrile; at 70℃; [000802] Tetrabutylammonium cyanide (50 g) was added to Example 1.75.1 (67.1 g) in 300 mL acetonitrile, and the mixture was heated to 70C overnight. The mixture was cooled, poured into diethyl ether, and rinsed with water and brine. The mixture was then concentrated and chromatographed on silica gel using 2-20% ethyl acetate in heptanes to give the title compound.
In acetonitrile; at 70℃; Tetrabutylammonium cyanide (50 g) was added to Example 1.21.1 (67.1 g) in 300 mL acetonitrile, and the mixture was heated to 70 C overnight. The mixture was cooled, poured into diethyl ether, and rinsed with water and brine. The mixture was concentrated and chromatographed on silica gel using 2-20% ethyl acetate in heptane to give the title compound.
In acetonitrile; at 70℃; Tetrabutylammonium cyanide (50 g) was added to Example 1.21.1 (67.1 g) in 300 mLacetonitrile, and the mixture was heated to 70 oc overnight. The mixture was cooled, poured intodiethyl ether, and rinsed with water and brine. The mixture was concentrated and chromatographedon silica gel using 2-20% ethyl acetate in heptane to give the title compound
In acetonitrile; at 70℃; Tetrabutylammonium cyanide (50 g) was added to Example 1.75.1 (67.1 g) in 300 mL acetonitrile, and the mixture was heated to 70oC overnight. The mixture was cooled, poured into diethyl ether, and rinsed with water and brine. The mixture was then concentrated and chromatographed on silica gel using 2-20% ethyl acetate in heptanes to give the title compound.
In acetonitrile; at 70℃; Tetrabutylammonium cyanide (50 g) was added to Example 1.75.1 (67.1 g) in 300 mLacetonitrile, and the mixture was heated to 70C overnight. The mixture was cooled, poured intodiethyl ether, and rinsed with water and brine. The mixture was then concentrated and20 chromatographed on silica gel using 2-20% ethyl acetate in heptanes to give the title compound
In acetonitrile; at 70℃; Tetrabutylammonium cyanide (50 g) was added to Example 1.75.1 (67.1 g) in 300 mL acetonitrile, and the mixture was heated to 70 C. overnight. The mixture was cooled, poured into diethyl ether, and rinsed with water and brine. The mixture was then concentrated and chromatographed on silica gel using 2-20% ethyl acetate in heptanes to give the title compound.

Reference： [1]Patent: US2016/158377,2016,A1 .Location in patent: Paragraph 0729
[2]Patent: WO2016/94509,2016,A1 .Location in patent: Paragraph 000802
[3]Patent: WO2017/214458,2017,A2 .Location in patent: Page/Page column 372
[4]Patent: WO2017/214301,2017,A1 .Location in patent: Page/Page column 318
[5]Patent: WO2017/214462,2017,A2 .Location in patent: Page/Page column 513
[6]Patent: WO2017/214282,2017,A1 .Location in patent: Page/Page column 471
[7]Patent: US2017/355769,2017,A1 .Location in patent: Paragraph 1780
  • 5
  • [ 878741-84-5 ]
  • methyl 3-(2-aminoethyl)-5-bromobenzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With borane-THF In tetrahydrofuran 1.21.3 1.21.3 methyl 3-(2-aminoethyl)-5-bromobenzoate borane-tetrahydrofuran complex (126 mL, 1M solution) was added to a solution of Example 1.21.2 (16 g) in 200 mL tetrahydrofuran, and the mixture was stirred overnight. The reaction was carefully quenched with methanol (50 mL), and then concentrated to 50 mL volume. The mixture was then taken up in 120 mL methanol/120 mL 4M HCl/120 mL dioxane, and stirred overnight. The organics were removed by evaporation under reduced pressure, and the residue was extracted with diethyl ether (2×). The organic extracts were discarded. The aqueous layer was basified with solid K2CO3, and then extracted with ethyl acetate, and dichloromethane (2×). The extracts were combined, dried over Na2SO4, filtered and concentrated to give the title compound.
With borane-THF In tetrahydrofuran at 70℃; 1.1.75.1.75.3 1.75.3 methyl 3-(2-aminoethyl)-5-bromobenzoate [000803] Borane-THF complex (126 mL, 1M solution) was added to a solution of Example 1.75.2 (16 g) in 200 mL tetrahydrofuran, and the mixture was stirred overnight. The reaction was carefully quenched with methanol (50 mL), and then concentrated to 50 mL volume. The mixture was taken up in 120 mL methanol / 120 mL 4M HC1 / 120 mL dioxane, and stirred overnight. The organics were removed under reduced pressure, and the residue was extracted twice with diethyl ether. The extracts were discarded. The organic layer was basified with solid K2CO3, and then extracted with ethyl acetate, and dichloromethane (2x). The extracts were combined, dried over NaaSOzi, filtered and concentrated to give the title compound.
With borane-THF In tetrahydrofuran 1.1.21.1.21.3 1.21.3 methyl 3-(2-aminoethyl)-5-bromobenzoate Borane-tetrahydrofuran complex (126 mL, 1M solution) was added to a solution of Example 1.21.2 (16 g) in 200 mL tetrahydrofuran, and the mixture was stirred overnight. The reaction was carefully quenched with methanol (50 mL), and then concentrated to 50 mL volume. The mixture was then taken up in 120 mL methanol / 120 mL 4M HC1 / 120 mL dioxane, and stirred overnight. The organics were removed by evaporation under reduced pressure, and the residue was extracted with diethyl ether (2 x). The organic extracts were discarded. The aqueous layer was basified with solid K2CO3, and then extracted with ethyl acetate, and dichloromethane (2x). The extracts were combined, dried over Na2S04, filtered and concentrated to give the title compound.
With borane-THF In tetrahydrofuran 1.21.3 1.21.3 methyl 3-(2-aminoethyl)-5-bromobenzoate Borane-tetrahydrofuran complex (126 mL, 1M solution) was added to a solution of Example1.21.2 (16 g) in 200 mL tetrahydrofuran, and the mixture was stirred overnight. The reaction wascarefully quenched with methanol (50 mL), and then concentrated to 50 mL volume. The mixturewas then taken up in 120 mL methanol I 120 mL 4M HCl I 120 mL dioxane, and stirred overnight.The organics were removed by evaporation under reduced pressure, and the residue was extracted15 with diethyl ether (2 x). The organic extracts were discarded. The aqueous layer was basified withsolid K2C03 , and then extracted with ethyl acetate, and dichloromethane (2x). The extracts werecombined, dried over Na2S04 , filtered and concentrated to give the title compound
With borane-THF In tetrahydrofuran 1.1.75.1.75.3 1.75.3 methyl 3-(2-aminoethyl)-5-bromobenzoate Borane-THF complex (126 mL, 1M solution) was added to a solution of Example 1.75.2 (16 g) in 200 mL tetrahydrofuran, and the mixture was stirred overnight. The reaction was carefully quenched with methanol (50 mL), and then concentrated to 50 mL volume. The mixture was taken up in 120 mL methanol / 120 mL 4M HCl / 120 mL dioxane, and stirred overnight. The organics were removed under reduced pressure, and the residue was extracted twice with diethyl ether. The extracts were discarded. The organic layer was basified with solid K2CO3, and then extracted with ethyl acetate, and dichloromethane (2x). The extracts were combined, dried over Na2SO4, filtered and concentrated to give the title compound.
With borane-THF In tetrahydrofuran 1.75.3 1.75.3 methyl 3-(2-aminoethyl)-5-bromobenzoate Borane-THF complex (126 mL, 1M solution) was added to a solution of Example 1.75.2(16 g) in 200 mL tetrahydrofuran, and the mixture was stirred overnight. The reaction was carefullyquenched with methanol (50 mL), and then concentrated to 50 mL volume. The mixture was taken25 up in 120 mL methanol I 120 mL 4M HCl I 120 mL dioxane, and stirred overnight. The organicswere removed under reduced pressure, and the residue was extracted twice with diethyl ether. Theextracts were discarded. The organic layer was basified with solid K2C03 , and then extracted withethyl acetate, and dichloromethane (2x). The extracts were combined, dried over Na2S04, filteredand concentrated to give the title compound..
With borane-THF In tetrahydrofuran 1.75.3 1.75.3 methyl 3-(2-aminoethyl)-5-bromobenzoate Borane-THF complex (126 mE, 1M solution) was added to a solution of Example 1.75.2 (16 g) in 200 mE tetrahydrofuran, and the mixture was stirred overnight. The reaction was carefully quenched with methanol (50 mL), and then concentrated to 50 mL volume. The mixture was taken up in 120 mL methanol/120 mL 4M HCl/120 mL dioxane, and stirred overnight. The organics were removed under reduced pressure, and the residue was extracted twice with diethyl ether. The extracts were discarded. The organic layer was basified with solid K2C03, and then extracted with ethyl acetate, and dichloromethane (2x). The extracts were combined, dried over Na2504, filtered and concentrated to give the title compound.

Reference： [1]Current Patent Assignee: ABBVIE INC - US2016/158377, 2016, A1 Location in patent: Paragraph 0730
[2]Current Patent Assignee: ABBVIE INC - WO2016/94509, 2016, A1 Location in patent: Paragraph 000803
[3]Current Patent Assignee: ABBVIE INC - WO2017/214458, 2017, A2 Location in patent: Page/Page column 372
[4]Current Patent Assignee: ABBVIE INC - WO2017/214301, 2017, A1 Location in patent: Page/Page column 318
[5]Current Patent Assignee: ABBVIE INC - WO2017/214462, 2017, A2 Location in patent: Page/Page column 514
[6]Current Patent Assignee: ABBVIE INC - WO2017/214282, 2017, A1 Location in patent: Page/Page column 471
[7]Current Patent Assignee: ABBVIE INC - US2017/355769, 2017, A1 Location in patent: Paragraph 1781
  • 6
  • [ 878741-84-5 ]
  • methyl 3-bromo-5-(2-(2,2,2-trifluoroacetamido)ethyl)benzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C
Multi-step reaction with 2 steps 1: borane-THF / tetrahydrofuran / 70 °C 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C
Multi-step reaction with 2 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C
Multi-step reaction with 2 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C
Multi-step reaction with 2 steps 1: borane-THF / tetrahydrofuran 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C
Multi-step reaction with 2 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C
Multi-step reaction with 2 steps 1: borane-THF / tetrahydrofuran 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C

Reference： [1]Current Patent Assignee: ABBVIE INC - US2016/158377, 2016, A1
[2]Current Patent Assignee: ABBVIE INC - WO2016/94509, 2016, A1
[3]Current Patent Assignee: ABBVIE INC - WO2017/214458, 2017, A2
[4]Current Patent Assignee: ABBVIE INC - WO2017/214301, 2017, A1
[5]Current Patent Assignee: ABBVIE INC - WO2017/214462, 2017, A2
[6]Current Patent Assignee: ABBVIE INC - WO2017/214282, 2017, A1
[7]Current Patent Assignee: ABBVIE INC - US2017/355769, 2017, A1
  • 7
  • [ 878741-84-5 ]
  • methyl 6-bromo-2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-8-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / ethyl acetate / 2 h
Multi-step reaction with 3 steps 1: borane-THF / tetrahydrofuran / 70 °C 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h
Multi-step reaction with 3 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h
Multi-step reaction with 3 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2.17 h / Cooling with ice
Multi-step reaction with 3 steps 1: borane-THF / tetrahydrofuran 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h
Multi-step reaction with 3 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h
Multi-step reaction with 3 steps 1: borane-THF / tetrahydrofuran 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h

Reference： [1]Current Patent Assignee: ABBVIE INC - US2016/158377, 2016, A1
[2]Current Patent Assignee: ABBVIE INC - WO2016/94509, 2016, A1
[3]Current Patent Assignee: ABBVIE INC - WO2017/214458, 2017, A2
[4]Current Patent Assignee: ABBVIE INC - WO2017/214301, 2017, A1
[5]Current Patent Assignee: ABBVIE INC - WO2017/214462, 2017, A2
[6]Current Patent Assignee: ABBVIE INC - WO2017/214282, 2017, A1
[7]Current Patent Assignee: ABBVIE INC - US2017/355769, 2017, A1
  • 8
  • [ 878741-84-5 ]
  • methyl 6-((2-((tert-butoxycarbonyl)(methyl)amino)ethyl)(methyl)amino)-2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-8-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / ethyl acetate / 2 h 4: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 80 °C
Multi-step reaction with 4 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 80 °C
Multi-step reaction with 4 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2.17 h / Cooling with ice 4: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 80 °C
Reference： [1]Current Patent Assignee: ABBVIE INC - US2016/158377, 2016, A1
[2]Current Patent Assignee: ABBVIE INC - WO2017/214458, 2017, A2
[3]Current Patent Assignee: ABBVIE INC - WO2017/214301, 2017, A1
  • 9
  • [ 878741-84-5 ]
  • methyl 2-(5-bromo-6-(tert-butoxycarbonyl)pyridin-2-yl)-6-((2-((tert-butoxycarbonyl)(methyl)amino)ethyl)(methyl)amino)-1,2,3,4-tetrahydroisoquinoline-8-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: borane-THF / tetrahydrofuran 2.1: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3.1: sulfuric acid / ethyl acetate / 2 h 4.1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 80 °C 5.1: potassium carbonate; triethylamine / water; methanol; tetrahydrofuran 5.2: 50 °C
Multi-step reaction with 6 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 80 °C 5: potassium carbonate; water / tetrahydrofuran; methanol 6: triethylamine / N,N-dimethyl-formamide / 50 °C
Multi-step reaction with 5 steps 1.1: borane-THF / tetrahydrofuran 2.1: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3.1: sulfuric acid / 2.17 h / Cooling with ice 4.1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 80 °C 5.1: potassium carbonate / tetrahydrofuran; water; methanol 5.2: 50 °C
Reference： [1]Current Patent Assignee: ABBVIE INC - US2016/158377, 2016, A1
[2]Current Patent Assignee: ABBVIE INC - WO2017/214458, 2017, A2
[3]Current Patent Assignee: ABBVIE INC - WO2017/214301, 2017, A1
  • 10
  • [ 878741-84-5 ]
  • methyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-8-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / ethyl acetate / 2 h 4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / 1,4-dioxane / 24 h / 70 °C
Multi-step reaction with 4 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 24 h / 70 °C
Multi-step reaction with 4 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2.17 h / Cooling with ice 4: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 24 h / 70 °C
Reference： [1]Current Patent Assignee: ABBVIE INC - US2016/158377, 2016, A1
[2]Current Patent Assignee: ABBVIE INC - WO2017/214458, 2017, A2
[3]Current Patent Assignee: ABBVIE INC - WO2017/214301, 2017, A1
  • 11
  • [ 878741-84-5 ]
  • methyl 6-hydroxy-2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-8-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / ethyl acetate / 2 h 4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / 1,4-dioxane / 24 h / 70 °C 5: sodium hydroxide; dihydrogen peroxide / water; tetrahydrofuran; ethyl acetate / 1.5 h
Multi-step reaction with 5 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 24 h / 70 °C 5: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 1.5 h
Multi-step reaction with 5 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2.17 h / Cooling with ice 4: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 24 h / 70 °C 5: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 1.5 h
Reference： [1]Current Patent Assignee: ABBVIE INC - US2016/158377, 2016, A1
[2]Current Patent Assignee: ABBVIE INC - WO2017/214458, 2017, A2
[3]Current Patent Assignee: ABBVIE INC - WO2017/214301, 2017, A1
  • 12
  • [ 878741-84-5 ]
  • methyl 6-methoxy-2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-8-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / ethyl acetate / 2 h 4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / 1,4-dioxane / 24 h / 70 °C 5: sodium hydroxide; dihydrogen peroxide / water; tetrahydrofuran; ethyl acetate / 1.5 h 6: diazomethyl-trimethyl-silane / methanol; diethyl ether / 24 h
Multi-step reaction with 6 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 24 h / 70 °C 5: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 1.5 h 6: methanol; diethyl ether / 24 h
Multi-step reaction with 6 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2.17 h / Cooling with ice 4: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 24 h / 70 °C 5: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 1.5 h 6: methanol; diethyl ether / 24 h
Reference： [1]Current Patent Assignee: ABBVIE INC - US2016/158377, 2016, A1
[2]Current Patent Assignee: ABBVIE INC - WO2017/214458, 2017, A2
[3]Current Patent Assignee: ABBVIE INC - WO2017/214301, 2017, A1
  • 13
  • [ 878741-84-5 ]
  • methyl 6-(3-((tert-butoxycarbonyl)(methyl)amino)prop-1-yn-1-yl)-2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-8-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: borane-THF / tetrahydrofuran / 70 °C 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 1,4-dioxane / 50 °C
Multi-step reaction with 4 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 50 °C
Multi-step reaction with 4 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2.17 h / Cooling with ice 4: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 1,4-dioxane / 50 °C
Multi-step reaction with 4 steps 1: borane-THF / tetrahydrofuran 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 1,4-dioxane / 50 °C
Multi-step reaction with 4 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 1,4-dioxane / 50 °C
Multi-step reaction with 4 steps 1: borane-THF / tetrahydrofuran 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 50 °C

Reference： [1]Current Patent Assignee: ABBVIE INC - WO2016/94509, 2016, A1
[2]Current Patent Assignee: ABBVIE INC - WO2017/214458, 2017, A2
[3]Current Patent Assignee: ABBVIE INC - WO2017/214301, 2017, A1
[4]Current Patent Assignee: ABBVIE INC - WO2017/214462, 2017, A2
[5]Current Patent Assignee: ABBVIE INC - WO2017/214282, 2017, A1
[6]Current Patent Assignee: ABBVIE INC - US2017/355769, 2017, A1
  • 14
  • [ 878741-84-5 ]
  • methyl 6-(3-((tert-butoxycarbonyl)(methyl)amino)propyl)-2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-8-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: borane-THF / tetrahydrofuran / 70 °C 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 1,4-dioxane / 50 °C 5: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran; methanol / 12 h / 50 °C / 2585.81 Torr
Multi-step reaction with 5 steps 1: borane-THF / tetrahydrofuran 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 1,4-dioxane / 50 °C 5: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran; methanol / 12 h / 50 °C / 2585.81 Torr
Multi-step reaction with 5 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 1,4-dioxane / 50 °C 5: methanol; 20% palladium hydroxide-activated charcoal / tetrahydrofuran / 12 h / 50 °C / 2585.81 Torr
Multi-step reaction with 5 steps 1: borane-THF / tetrahydrofuran 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 50 °C 5: Pd(OH)2/C / tetrahydrofuran; methanol / 12 h / 50 °C / 2585.81 Torr

Reference： [1]Current Patent Assignee: ABBVIE INC - WO2016/94509, 2016, A1
[2]Current Patent Assignee: ABBVIE INC - WO2017/214462, 2017, A2
[3]Current Patent Assignee: ABBVIE INC - WO2017/214282, 2017, A1
[4]Current Patent Assignee: ABBVIE INC - US2017/355769, 2017, A1
  • 15
  • [ 878741-84-5 ]
  • C20H30N2O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1: borane-THF / tetrahydrofuran / 70 °C 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 1,4-dioxane / 50 °C 5: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran; methanol / 12 h / 50 °C / 2585.81 Torr 6: potassium carbonate; water / tetrahydrofuran; methanol
Multi-step reaction with 6 steps 1: borane-THF / tetrahydrofuran 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 1,4-dioxane / 50 °C 5: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran; methanol / 12 h / 50 °C / 2585.81 Torr 6: potassium carbonate; water / tetrahydrofuran; methanol
Reference： [1]Current Patent Assignee: ABBVIE INC - WO2016/94509, 2016, A1
[2]Current Patent Assignee: ABBVIE INC - WO2017/214462, 2017, A2
  • 16
  • [ 878741-84-5 ]
  • methyl 2-(5-bromo-6-(tert-butoxycarbonyl)pyridin-2-yl)-6-(3-((tert-butoxycarbonyl)(methyl)amino)propyl)-1,2,3,4-tetrahydroisoquinoline-8-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1: borane-THF / tetrahydrofuran / 70 °C 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 1,4-dioxane / 50 °C 5: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran; methanol / 12 h / 50 °C / 2585.81 Torr 6: potassium carbonate; water / tetrahydrofuran; methanol 7: triethylamine / N,N-dimethyl-formamide / 60 °C
Multi-step reaction with 7 steps 1: borane-THF / tetrahydrofuran 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 1,4-dioxane / 50 °C 5: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran; methanol / 12 h / 50 °C / 2585.81 Torr 6: potassium carbonate; water / tetrahydrofuran; methanol 7: triethylamine / N,N-dimethyl-formamide / 60 °C
Multi-step reaction with 6 steps 1.1: borane-THF / tetrahydrofuran 2.1: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3.1: sulfuric acid / 2 h 4.1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 50 °C 5.1: Pd(OH)2/C / tetrahydrofuran; methanol / 12 h / 50 °C / 2585.81 Torr 6.1: triethylamine; potassium carbonate / tetrahydrofuran; water; methanol 6.2: 60 °C
Reference： [1]Current Patent Assignee: ABBVIE INC - WO2016/94509, 2016, A1
[2]Current Patent Assignee: ABBVIE INC - WO2017/214462, 2017, A2
[3]Current Patent Assignee: ABBVIE INC - US2017/355769, 2017, A1
  • 17
  • [ 878741-84-5 ]
  • methyl 6-(3-((tert-butoxycarbonyl)(methyl)amino)propyl)-2-(6-(tert-butoxycarbonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline-8-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1: borane-THF / tetrahydrofuran / 70 °C 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 1,4-dioxane / 50 °C 5: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran; methanol / 12 h / 50 °C / 2585.81 Torr 6: potassium carbonate; water / tetrahydrofuran; methanol 7: triethylamine / N,N-dimethyl-formamide / 60 °C 8: triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / acetonitrile / 60 - 75 °C
Multi-step reaction with 8 steps 1: borane-THF / tetrahydrofuran 2: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 1,4-dioxane / 50 °C 5: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran; methanol / 12 h / 50 °C / 2585.81 Torr 6: potassium carbonate; water / tetrahydrofuran; methanol 7: triethylamine / N,N-dimethyl-formamide / 60 °C 8: triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 60 - 75 °C
Multi-step reaction with 7 steps 1.1: borane-THF / tetrahydrofuran 2.1: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3.1: sulfuric acid / 2 h 4.1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 50 °C 5.1: Pd(OH)2/C / tetrahydrofuran; methanol / 12 h / 50 °C / 2585.81 Torr 6.1: triethylamine; potassium carbonate / tetrahydrofuran; water; methanol 6.2: 60 °C 7.1: triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 5 h / 60 - 75 °C
Reference： [1]Current Patent Assignee: ABBVIE INC - WO2016/94509, 2016, A1
[2]Current Patent Assignee: ABBVIE INC - WO2017/214462, 2017, A2
[3]Current Patent Assignee: ABBVIE INC - US2017/355769, 2017, A1
  • 18
  • [ 878741-84-5 ]
  • C20H31N3O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: borane-THF / tetrahydrofuran 2: triethylamine / dichloromethane / 72 h / 0 - 20 °C 3: sulfuric acid / 2 h 4: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 80 °C 5: potassium carbonate; water / tetrahydrofuran; methanol
Reference： [1]Current Patent Assignee: ABBVIE INC - WO2017/214458, 2017, A2
  • 19
  • [ 878741-84-5 ]
  • 6-(6-(3-((tert-butoxycarbonyl)(methyl)amino)propyl)-8-(methoxycarbonyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-((3-(2-((2-((4-((tert-butyldiphenylsilyl)oxy)-2,2-dimethylbutoxy)sulfonyl)ethyl)amino)ethoxy)-5,7-dimethyladamantan-1-yl)methyl)-5-methyl-1H-pyrazol-4-yl)picolinic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1.1: borane-THF / tetrahydrofuran 2.1: trimethylamine / dichloromethane / 72 h / 0 - 20 °C 3.1: sulfuric acid / 2 h 4.1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 50 °C 5.1: Pd(OH)2/C / tetrahydrofuran; methanol / 12 h / 50 °C / 2585.81 Torr 6.1: triethylamine; potassium carbonate / tetrahydrofuran; water; methanol 6.2: 60 °C 7.1: triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 5 h / 60 - 75 °C 8.1: tris-(dibenzylideneacetone)dipalladium(0); 1,3,5,7-tetramethyl-6-tetradecane-2,4,8-trioxa-6-phosphaadamantane; potassium phosphate / 1,4-dioxane; water / 70 °C / Inert atmosphere
Reference： [1]Current Patent Assignee: ABBVIE INC - US2017/355769, 2017, A1
  • 20
  • [ 878741-84-5 ]
  • methyl 3-amino-5-(1-cyanocyclobutyl)benzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 16 h / 20 °C 2.1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / N,N-dimethyl-formamide / 16 h / 150 °C 2.2: 1 h
Reference： [1]Macdonald, Jonathan D.; Chacón Simon, Selena; Han, Changho; Wang, Feng; Shaw, J. Grace; Howes, Jennifer E.; Sai, Jiqing; Yuh, Joannes P.; Camper, Demarco; Alicie, Bethany M.; Alvarado, Joseph; Nikhar, Sameer; Payne, William; Aho, Erin R.; Bauer, Joshua A.; Zhao, Bin; Phan, Jason; Thomas, Lance R.; Rossanese, Olivia W.; Tansey, William P.; Waterson, Alex G.; Stauffer, Shaun R.; Fesik, Stephen W. [Journal of Medicinal Chemistry, 2019, vol. 62, # 24, p. 11232 - 11259]
  • 21
  • [ 878741-84-5 ]
  • methyl 3-((5-bromo-2-hydroxyphenyl)sulfonamido)-5-(1-cyanocyclobutyl)benzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 16 h / 20 °C 2.1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / N,N-dimethyl-formamide / 16 h / 150 °C 2.2: 1 h 3.1: pyridine / dichloromethane / 20 °C
Reference： [1]Macdonald, Jonathan D.; Chacón Simon, Selena; Han, Changho; Wang, Feng; Shaw, J. Grace; Howes, Jennifer E.; Sai, Jiqing; Yuh, Joannes P.; Camper, Demarco; Alicie, Bethany M.; Alvarado, Joseph; Nikhar, Sameer; Payne, William; Aho, Erin R.; Bauer, Joshua A.; Zhao, Bin; Phan, Jason; Thomas, Lance R.; Rossanese, Olivia W.; Tansey, William P.; Waterson, Alex G.; Stauffer, Shaun R.; Fesik, Stephen W. [Journal of Medicinal Chemistry, 2019, vol. 62, # 24, p. 11232 - 11259]
  • 22
  • [ 878741-84-5 ]
  • 3-((5-bromo-2-hydroxyphenyl)sulfonamido)-5-(1-cyanocyclobutyl)benzoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 16 h / 20 °C 2.1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / N,N-dimethyl-formamide / 16 h / 150 °C 2.2: 1 h 3.1: pyridine / dichloromethane / 20 °C 4.1: lithium hydroxide / tetrahydrofuran / 20 °C
Reference： [1]Macdonald, Jonathan D.; Chacón Simon, Selena; Han, Changho; Wang, Feng; Shaw, J. Grace; Howes, Jennifer E.; Sai, Jiqing; Yuh, Joannes P.; Camper, Demarco; Alicie, Bethany M.; Alvarado, Joseph; Nikhar, Sameer; Payne, William; Aho, Erin R.; Bauer, Joshua A.; Zhao, Bin; Phan, Jason; Thomas, Lance R.; Rossanese, Olivia W.; Tansey, William P.; Waterson, Alex G.; Stauffer, Shaun R.; Fesik, Stephen W. [Journal of Medicinal Chemistry, 2019, vol. 62, # 24, p. 11232 - 11259]
  • 23
  • [ 878741-84-5 ]
  • 3-amino-5-(1-cyanocyclobutyl)-N-methylbenzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 16 h / 20 °C 2.1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / N,N-dimethyl-formamide / 16 h / 150 °C 2.2: 1 h 3.1: tetrahydrofuran / 3 h / 65 °C
Reference： [1]Macdonald, Jonathan D.; Chacón Simon, Selena; Han, Changho; Wang, Feng; Shaw, J. Grace; Howes, Jennifer E.; Sai, Jiqing; Yuh, Joannes P.; Camper, Demarco; Alicie, Bethany M.; Alvarado, Joseph; Nikhar, Sameer; Payne, William; Aho, Erin R.; Bauer, Joshua A.; Zhao, Bin; Phan, Jason; Thomas, Lance R.; Rossanese, Olivia W.; Tansey, William P.; Waterson, Alex G.; Stauffer, Shaun R.; Fesik, Stephen W. [Journal of Medicinal Chemistry, 2019, vol. 62, # 24, p. 11232 - 11259]
  • 24
  • [ 878741-84-5 ]
  • 3-((5-bromo-2-hydroxyphenyl)sulfonamido)-5-(1-cyanocyclobutyl)-N-methylbenzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 16 h / 20 °C 2.1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / N,N-dimethyl-formamide / 16 h / 150 °C 2.2: 1 h 3.1: tetrahydrofuran / 3 h / 65 °C 4.1: pyridine / dichloromethane / 20 °C
Reference： [1]Macdonald, Jonathan D.; Chacón Simon, Selena; Han, Changho; Wang, Feng; Shaw, J. Grace; Howes, Jennifer E.; Sai, Jiqing; Yuh, Joannes P.; Camper, Demarco; Alicie, Bethany M.; Alvarado, Joseph; Nikhar, Sameer; Payne, William; Aho, Erin R.; Bauer, Joshua A.; Zhao, Bin; Phan, Jason; Thomas, Lance R.; Rossanese, Olivia W.; Tansey, William P.; Waterson, Alex G.; Stauffer, Shaun R.; Fesik, Stephen W. [Journal of Medicinal Chemistry, 2019, vol. 62, # 24, p. 11232 - 11259]
  • 25
  • [ 878741-84-5 ]
  • 3-((5-bromo-3-chloro-2-hydroxyphenyl)sulfonamido)-5-(1-cyanocyclobutyl)-N-methylbenzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 16 h / 20 °C 2.1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / N,N-dimethyl-formamide / 16 h / 150 °C 2.2: 1 h 3.1: tetrahydrofuran / 3 h / 65 °C 4.1: pyridine / dichloromethane / 20 °C
Reference： [1]Macdonald, Jonathan D.; Chacón Simon, Selena; Han, Changho; Wang, Feng; Shaw, J. Grace; Howes, Jennifer E.; Sai, Jiqing; Yuh, Joannes P.; Camper, Demarco; Alicie, Bethany M.; Alvarado, Joseph; Nikhar, Sameer; Payne, William; Aho, Erin R.; Bauer, Joshua A.; Zhao, Bin; Phan, Jason; Thomas, Lance R.; Rossanese, Olivia W.; Tansey, William P.; Waterson, Alex G.; Stauffer, Shaun R.; Fesik, Stephen W. [Journal of Medicinal Chemistry, 2019, vol. 62, # 24, p. 11232 - 11259]
  • 26
  • [ 878741-84-5 ]
  • [ 627-31-6 ]
  • methyl 3-bromo-5-(1-cyanocyclobutyl)benzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
60% With potassium <i>tert</i>-butylate In tetrahydrofuran at 20℃; for 16h;
Reference： [1]Macdonald, Jonathan D.; Chacón Simon, Selena; Han, Changho; Wang, Feng; Shaw, J. Grace; Howes, Jennifer E.; Sai, Jiqing; Yuh, Joannes P.; Camper, Demarco; Alicie, Bethany M.; Alvarado, Joseph; Nikhar, Sameer; Payne, William; Aho, Erin R.; Bauer, Joshua A.; Zhao, Bin; Phan, Jason; Thomas, Lance R.; Rossanese, Olivia W.; Tansey, William P.; Waterson, Alex G.; Stauffer, Shaun R.; Fesik, Stephen W. [Journal of Medicinal Chemistry, 2019, vol. 62, # 24, p. 11232 - 11259]
  • 27
  • [ 478375-40-5 ]
  • [ 7677-24-9 ]
  • [ 878741-84-5 ]
Reference： [1]Journal of Medicinal Chemistry,2019,vol. 62,p. 11232 - 11259
  • 28
  • [ 878741-84-5 ]
  • C28H28N2O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 1.2: 72 h / 0 - 20 °C / Inert atmosphere 1.3: 16 h / 20 °C 2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C 2.2: 18 h / 20 °C / Inert atmosphere 3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 4.1: potassium acetate; XPhos; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II) / ethanol / 1 h / 80 °C / Inert atmosphere 5.1: potassium carbonate / water; ethanol / 17 h / 80 °C
Multi-step reaction with 5 steps 1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 1.2: 72 h / 0 - 20 °C / Inert atmosphere 2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C 2.2: 18 h / 20 °C / Inert atmosphere 3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 4.1: potassium acetate; XPhos; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II) / ethanol / 1 h / 80 °C / Inert atmosphere 5.1: potassium carbonate / water; ethanol / 17 h / 80 °C
Reference： [1]Lorthiois, Edwige; Roache, James; Barnes-Seeman, David; Altmann, Eva; Hassiepen, Ulrich; Turner, Gordon; Duvadie, Rohit; Hornak, Viktor; Karki, Rajeshri G.; Schiering, Nikolaus; Weihofen, Wilhelm A.; Perruccio, Francesca; Calhoun, Amy; Fazal, Tanzina; Dedic, Darija; Durand, Corinne; Dussauge, Solene; Fettis, Kamal; Tritsch, Fabien; Dentel, Celine; Druet, Adelaide; Liu, Donglei; Kirman, Louise; Lachal, Julie; Namoto, Kenji; Bevan, Douglas; Mo, Rose; Monnet, Gabriela; Muller, Lionel; Zessis, Richard; Huang, Xueming; Lindsley, Loren; Currie, Treeve; Chiu, Yu-Hsin; Fridrich, Cary; Delgado, Peter; Wang, Shuangxi; Hollis-Symynkywicz, Micah; Berghausen, Joerg; Williams, Eric; Liu, Hong; Liang, Guiqing; Kim, Hyungchul; Hoffmann, Peter; Hein, Andreas; Ramage, Paul; D'arcy, Allan; Harlfinger, Stefanie; Renatus, Martin; Ruedisser, Simon; Feldman, David; Elliott, Jason; Sedrani, Richard; Maibaum, Juergen; Adams, Christopher M. [Journal of Medicinal Chemistry, 2020, vol. 63, # 15, p. 8088 - 8113]
[2]Lorthiois, Edwige; Roache, James; Barnes-Seeman, David; Altmann, Eva; Hassiepen, Ulrich; Turner, Gordon; Duvadie, Rohit; Hornak, Viktor; Karki, Rajeshri G.; Schiering, Nikolaus; Weihofen, Wilhelm A.; Perruccio, Francesca; Calhoun, Amy; Fazal, Tanzina; Dedic, Darija; Durand, Corinne; Dussauge, Solene; Fettis, Kamal; Tritsch, Fabien; Dentel, Celine; Druet, Adelaide; Liu, Donglei; Kirman, Louise; Lachal, Julie; Namoto, Kenji; Bevan, Douglas; Mo, Rose; Monnet, Gabriela; Muller, Lionel; Zessis, Richard; Huang, Xueming; Lindsley, Loren; Currie, Treeve; Chiu, Yu-Hsin; Fridrich, Cary; Delgado, Peter; Wang, Shuangxi; Hollis-Symynkywicz, Micah; Berghausen, Joerg; Williams, Eric; Liu, Hong; Liang, Guiqing; Kim, Hyungchul; Hoffmann, Peter; Hein, Andreas; Ramage, Paul; D'arcy, Allan; Harlfinger, Stefanie; Renatus, Martin; Ruedisser, Simon; Feldman, David; Elliott, Jason; Sedrani, Richard; Maibaum, Juergen; Adams, Christopher M. [Journal of Medicinal Chemistry, 2020, vol. 63, # 15, p. 8088 - 8113]
  • 29
  • [ 878741-84-5 ]
  • (S)-2-(2-((3-(3-amino-2,3-dihydrobenzofuran-5-yl)-5-(2-cyanopropan-2-yl)benzyl)oxy)phenyl)acetic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 1.2: 72 h / 0 - 20 °C / Inert atmosphere 1.3: 16 h / 20 °C 2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C 2.2: 18 h / 20 °C / Inert atmosphere 3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 4.1: potassium acetate; XPhos; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II) / ethanol / 1 h / 80 °C / Inert atmosphere 5.1: potassium carbonate / water; ethanol / 17 h / 80 °C 6.1: sodium hydroxide / water; tetrahydrofuran; methanol / 16 h / 20 °C
Multi-step reaction with 6 steps 1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 1.2: 72 h / 0 - 20 °C / Inert atmosphere 2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C 2.2: 18 h / 20 °C / Inert atmosphere 3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 4.1: potassium acetate; XPhos; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II) / ethanol / 1 h / 80 °C / Inert atmosphere 5.1: potassium carbonate / water; ethanol / 17 h / 80 °C 6.1: sodium hydroxide / water; tetrahydrofuran; methanol / 16 h / 20 °C
Reference： [1]Lorthiois, Edwige; Roache, James; Barnes-Seeman, David; Altmann, Eva; Hassiepen, Ulrich; Turner, Gordon; Duvadie, Rohit; Hornak, Viktor; Karki, Rajeshri G.; Schiering, Nikolaus; Weihofen, Wilhelm A.; Perruccio, Francesca; Calhoun, Amy; Fazal, Tanzina; Dedic, Darija; Durand, Corinne; Dussauge, Solene; Fettis, Kamal; Tritsch, Fabien; Dentel, Celine; Druet, Adelaide; Liu, Donglei; Kirman, Louise; Lachal, Julie; Namoto, Kenji; Bevan, Douglas; Mo, Rose; Monnet, Gabriela; Muller, Lionel; Zessis, Richard; Huang, Xueming; Lindsley, Loren; Currie, Treeve; Chiu, Yu-Hsin; Fridrich, Cary; Delgado, Peter; Wang, Shuangxi; Hollis-Symynkywicz, Micah; Berghausen, Joerg; Williams, Eric; Liu, Hong; Liang, Guiqing; Kim, Hyungchul; Hoffmann, Peter; Hein, Andreas; Ramage, Paul; D'arcy, Allan; Harlfinger, Stefanie; Renatus, Martin; Ruedisser, Simon; Feldman, David; Elliott, Jason; Sedrani, Richard; Maibaum, Juergen; Adams, Christopher M. [Journal of Medicinal Chemistry, 2020, vol. 63, # 15, p. 8088 - 8113]
[2]Lorthiois, Edwige; Roache, James; Barnes-Seeman, David; Altmann, Eva; Hassiepen, Ulrich; Turner, Gordon; Duvadie, Rohit; Hornak, Viktor; Karki, Rajeshri G.; Schiering, Nikolaus; Weihofen, Wilhelm A.; Perruccio, Francesca; Calhoun, Amy; Fazal, Tanzina; Dedic, Darija; Durand, Corinne; Dussauge, Solene; Fettis, Kamal; Tritsch, Fabien; Dentel, Celine; Druet, Adelaide; Liu, Donglei; Kirman, Louise; Lachal, Julie; Namoto, Kenji; Bevan, Douglas; Mo, Rose; Monnet, Gabriela; Muller, Lionel; Zessis, Richard; Huang, Xueming; Lindsley, Loren; Currie, Treeve; Chiu, Yu-Hsin; Fridrich, Cary; Delgado, Peter; Wang, Shuangxi; Hollis-Symynkywicz, Micah; Berghausen, Joerg; Williams, Eric; Liu, Hong; Liang, Guiqing; Kim, Hyungchul; Hoffmann, Peter; Hein, Andreas; Ramage, Paul; D'arcy, Allan; Harlfinger, Stefanie; Renatus, Martin; Ruedisser, Simon; Feldman, David; Elliott, Jason; Sedrani, Richard; Maibaum, Juergen; Adams, Christopher M. [Journal of Medicinal Chemistry, 2020, vol. 63, # 15, p. 8088 - 8113]
  • 30
  • [ 878741-84-5 ]
  • (S)-2-(2-((3-(3-amino-2,3-dihydrobenzofuran-5-yl)-5-(2-cyanopropan-2-yl)benzyl)oxy)phenyl)acetic acid [ No CAS ]
  • (S)-2-(2-((3-(3-amino-2,3-dihydrobenzofuran-5-yl)-5-(1-amino-2-methyl-1-oxopropan-2-yl)benzyl)oxy)phenyl)acetic acid trifluoroacetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 1.2: 72 h / 0 - 20 °C / Inert atmosphere 1.3: 16 h / 20 °C 2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C 2.2: 18 h / 20 °C / Inert atmosphere 3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 4.1: potassium acetate; XPhos; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II) / ethanol / 1 h / 80 °C / Inert atmosphere 5.1: potassium carbonate / water; ethanol / 17 h / 80 °C 6.1: sodium hydroxide / <i>tert</i>-butyl alcohol / 22 h / 80 - 120 °C
Multi-step reaction with 6 steps 1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 1.2: 72 h / 0 - 20 °C / Inert atmosphere 2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C 2.2: 18 h / 20 °C / Inert atmosphere 3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 4.1: potassium acetate; XPhos; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II) / ethanol / 1 h / 80 °C / Inert atmosphere 5.1: potassium carbonate / water; ethanol / 17 h / 80 °C 6.1: sodium hydroxide / <i>tert</i>-butyl alcohol / 22 h / 80 - 120 °C
Reference： [1]Lorthiois, Edwige; Roache, James; Barnes-Seeman, David; Altmann, Eva; Hassiepen, Ulrich; Turner, Gordon; Duvadie, Rohit; Hornak, Viktor; Karki, Rajeshri G.; Schiering, Nikolaus; Weihofen, Wilhelm A.; Perruccio, Francesca; Calhoun, Amy; Fazal, Tanzina; Dedic, Darija; Durand, Corinne; Dussauge, Solene; Fettis, Kamal; Tritsch, Fabien; Dentel, Celine; Druet, Adelaide; Liu, Donglei; Kirman, Louise; Lachal, Julie; Namoto, Kenji; Bevan, Douglas; Mo, Rose; Monnet, Gabriela; Muller, Lionel; Zessis, Richard; Huang, Xueming; Lindsley, Loren; Currie, Treeve; Chiu, Yu-Hsin; Fridrich, Cary; Delgado, Peter; Wang, Shuangxi; Hollis-Symynkywicz, Micah; Berghausen, Joerg; Williams, Eric; Liu, Hong; Liang, Guiqing; Kim, Hyungchul; Hoffmann, Peter; Hein, Andreas; Ramage, Paul; D'arcy, Allan; Harlfinger, Stefanie; Renatus, Martin; Ruedisser, Simon; Feldman, David; Elliott, Jason; Sedrani, Richard; Maibaum, Juergen; Adams, Christopher M. [Journal of Medicinal Chemistry, 2020, vol. 63, # 15, p. 8088 - 8113]
[2]Lorthiois, Edwige; Roache, James; Barnes-Seeman, David; Altmann, Eva; Hassiepen, Ulrich; Turner, Gordon; Duvadie, Rohit; Hornak, Viktor; Karki, Rajeshri G.; Schiering, Nikolaus; Weihofen, Wilhelm A.; Perruccio, Francesca; Calhoun, Amy; Fazal, Tanzina; Dedic, Darija; Durand, Corinne; Dussauge, Solene; Fettis, Kamal; Tritsch, Fabien; Dentel, Celine; Druet, Adelaide; Liu, Donglei; Kirman, Louise; Lachal, Julie; Namoto, Kenji; Bevan, Douglas; Mo, Rose; Monnet, Gabriela; Muller, Lionel; Zessis, Richard; Huang, Xueming; Lindsley, Loren; Currie, Treeve; Chiu, Yu-Hsin; Fridrich, Cary; Delgado, Peter; Wang, Shuangxi; Hollis-Symynkywicz, Micah; Berghausen, Joerg; Williams, Eric; Liu, Hong; Liang, Guiqing; Kim, Hyungchul; Hoffmann, Peter; Hein, Andreas; Ramage, Paul; D'arcy, Allan; Harlfinger, Stefanie; Renatus, Martin; Ruedisser, Simon; Feldman, David; Elliott, Jason; Sedrani, Richard; Maibaum, Juergen; Adams, Christopher M. [Journal of Medicinal Chemistry, 2020, vol. 63, # 15, p. 8088 - 8113]
  • 31
  • [ 878741-84-5 ]
  • methyl 2-(2-((3-bromo-5-(2-cyanopropan-2-yl)benzyl)oxy)phenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 1.2: 72 h / 0 - 20 °C / Inert atmosphere 1.3: 16 h / 20 °C 2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C 2.2: 18 h / 20 °C / Inert atmosphere 3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
Multi-step reaction with 3 steps 1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 1.2: 72 h / 0 - 20 °C / Inert atmosphere 2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C 2.2: 18 h / 20 °C / Inert atmosphere 3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
Reference： [1]Lorthiois, Edwige; Roache, James; Barnes-Seeman, David; Altmann, Eva; Hassiepen, Ulrich; Turner, Gordon; Duvadie, Rohit; Hornak, Viktor; Karki, Rajeshri G.; Schiering, Nikolaus; Weihofen, Wilhelm A.; Perruccio, Francesca; Calhoun, Amy; Fazal, Tanzina; Dedic, Darija; Durand, Corinne; Dussauge, Solene; Fettis, Kamal; Tritsch, Fabien; Dentel, Celine; Druet, Adelaide; Liu, Donglei; Kirman, Louise; Lachal, Julie; Namoto, Kenji; Bevan, Douglas; Mo, Rose; Monnet, Gabriela; Muller, Lionel; Zessis, Richard; Huang, Xueming; Lindsley, Loren; Currie, Treeve; Chiu, Yu-Hsin; Fridrich, Cary; Delgado, Peter; Wang, Shuangxi; Hollis-Symynkywicz, Micah; Berghausen, Joerg; Williams, Eric; Liu, Hong; Liang, Guiqing; Kim, Hyungchul; Hoffmann, Peter; Hein, Andreas; Ramage, Paul; D'arcy, Allan; Harlfinger, Stefanie; Renatus, Martin; Ruedisser, Simon; Feldman, David; Elliott, Jason; Sedrani, Richard; Maibaum, Juergen; Adams, Christopher M. [Journal of Medicinal Chemistry, 2020, vol. 63, # 15, p. 8088 - 8113]
[2]Lorthiois, Edwige; Roache, James; Barnes-Seeman, David; Altmann, Eva; Hassiepen, Ulrich; Turner, Gordon; Duvadie, Rohit; Hornak, Viktor; Karki, Rajeshri G.; Schiering, Nikolaus; Weihofen, Wilhelm A.; Perruccio, Francesca; Calhoun, Amy; Fazal, Tanzina; Dedic, Darija; Durand, Corinne; Dussauge, Solene; Fettis, Kamal; Tritsch, Fabien; Dentel, Celine; Druet, Adelaide; Liu, Donglei; Kirman, Louise; Lachal, Julie; Namoto, Kenji; Bevan, Douglas; Mo, Rose; Monnet, Gabriela; Muller, Lionel; Zessis, Richard; Huang, Xueming; Lindsley, Loren; Currie, Treeve; Chiu, Yu-Hsin; Fridrich, Cary; Delgado, Peter; Wang, Shuangxi; Hollis-Symynkywicz, Micah; Berghausen, Joerg; Williams, Eric; Liu, Hong; Liang, Guiqing; Kim, Hyungchul; Hoffmann, Peter; Hein, Andreas; Ramage, Paul; D'arcy, Allan; Harlfinger, Stefanie; Renatus, Martin; Ruedisser, Simon; Feldman, David; Elliott, Jason; Sedrani, Richard; Maibaum, Juergen; Adams, Christopher M. [Journal of Medicinal Chemistry, 2020, vol. 63, # 15, p. 8088 - 8113]
  • 32
  • [ 878741-84-5 ]
  • C20H22BNO5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 1.2: 72 h / 0 - 20 °C / Inert atmosphere 1.3: 16 h / 20 °C 2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C 2.2: 18 h / 20 °C / Inert atmosphere 3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 4.1: potassium acetate; XPhos; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II) / ethanol / 1 h / 80 °C / Inert atmosphere
Multi-step reaction with 4 steps 1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 1.2: 72 h / 0 - 20 °C / Inert atmosphere 2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C 2.2: 18 h / 20 °C / Inert atmosphere 3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 4.1: potassium acetate; XPhos; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II) / ethanol / 1 h / 80 °C / Inert atmosphere
Reference： [1]Lorthiois, Edwige; Roache, James; Barnes-Seeman, David; Altmann, Eva; Hassiepen, Ulrich; Turner, Gordon; Duvadie, Rohit; Hornak, Viktor; Karki, Rajeshri G.; Schiering, Nikolaus; Weihofen, Wilhelm A.; Perruccio, Francesca; Calhoun, Amy; Fazal, Tanzina; Dedic, Darija; Durand, Corinne; Dussauge, Solene; Fettis, Kamal; Tritsch, Fabien; Dentel, Celine; Druet, Adelaide; Liu, Donglei; Kirman, Louise; Lachal, Julie; Namoto, Kenji; Bevan, Douglas; Mo, Rose; Monnet, Gabriela; Muller, Lionel; Zessis, Richard; Huang, Xueming; Lindsley, Loren; Currie, Treeve; Chiu, Yu-Hsin; Fridrich, Cary; Delgado, Peter; Wang, Shuangxi; Hollis-Symynkywicz, Micah; Berghausen, Joerg; Williams, Eric; Liu, Hong; Liang, Guiqing; Kim, Hyungchul; Hoffmann, Peter; Hein, Andreas; Ramage, Paul; D'arcy, Allan; Harlfinger, Stefanie; Renatus, Martin; Ruedisser, Simon; Feldman, David; Elliott, Jason; Sedrani, Richard; Maibaum, Juergen; Adams, Christopher M. [Journal of Medicinal Chemistry, 2020, vol. 63, # 15, p. 8088 - 8113]
[2]Lorthiois, Edwige; Roache, James; Barnes-Seeman, David; Altmann, Eva; Hassiepen, Ulrich; Turner, Gordon; Duvadie, Rohit; Hornak, Viktor; Karki, Rajeshri G.; Schiering, Nikolaus; Weihofen, Wilhelm A.; Perruccio, Francesca; Calhoun, Amy; Fazal, Tanzina; Dedic, Darija; Durand, Corinne; Dussauge, Solene; Fettis, Kamal; Tritsch, Fabien; Dentel, Celine; Druet, Adelaide; Liu, Donglei; Kirman, Louise; Lachal, Julie; Namoto, Kenji; Bevan, Douglas; Mo, Rose; Monnet, Gabriela; Muller, Lionel; Zessis, Richard; Huang, Xueming; Lindsley, Loren; Currie, Treeve; Chiu, Yu-Hsin; Fridrich, Cary; Delgado, Peter; Wang, Shuangxi; Hollis-Symynkywicz, Micah; Berghausen, Joerg; Williams, Eric; Liu, Hong; Liang, Guiqing; Kim, Hyungchul; Hoffmann, Peter; Hein, Andreas; Ramage, Paul; D'arcy, Allan; Harlfinger, Stefanie; Renatus, Martin; Ruedisser, Simon; Feldman, David; Elliott, Jason; Sedrani, Richard; Maibaum, Juergen; Adams, Christopher M. [Journal of Medicinal Chemistry, 2020, vol. 63, # 15, p. 8088 - 8113]
  • 33
  • [ 878741-84-5 ]
  • 2-(3-bromo-5-(hydroxylmethyl)phenyl)-2-methylpropanenitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 1.2: 72 h / 0 - 20 °C / Inert atmosphere 1.3: 16 h / 20 °C 2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C 2.2: 18 h / 20 °C / Inert atmosphere
Multi-step reaction with 2 steps 1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 1.2: 72 h / 0 - 20 °C / Inert atmosphere 2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C 2.2: 18 h / 20 °C / Inert atmosphere
Reference： [1]Lorthiois, Edwige; Roache, James; Barnes-Seeman, David; Altmann, Eva; Hassiepen, Ulrich; Turner, Gordon; Duvadie, Rohit; Hornak, Viktor; Karki, Rajeshri G.; Schiering, Nikolaus; Weihofen, Wilhelm A.; Perruccio, Francesca; Calhoun, Amy; Fazal, Tanzina; Dedic, Darija; Durand, Corinne; Dussauge, Solene; Fettis, Kamal; Tritsch, Fabien; Dentel, Celine; Druet, Adelaide; Liu, Donglei; Kirman, Louise; Lachal, Julie; Namoto, Kenji; Bevan, Douglas; Mo, Rose; Monnet, Gabriela; Muller, Lionel; Zessis, Richard; Huang, Xueming; Lindsley, Loren; Currie, Treeve; Chiu, Yu-Hsin; Fridrich, Cary; Delgado, Peter; Wang, Shuangxi; Hollis-Symynkywicz, Micah; Berghausen, Joerg; Williams, Eric; Liu, Hong; Liang, Guiqing; Kim, Hyungchul; Hoffmann, Peter; Hein, Andreas; Ramage, Paul; D'arcy, Allan; Harlfinger, Stefanie; Renatus, Martin; Ruedisser, Simon; Feldman, David; Elliott, Jason; Sedrani, Richard; Maibaum, Juergen; Adams, Christopher M. [Journal of Medicinal Chemistry, 2020, vol. 63, # 15, p. 8088 - 8113]
[2]Lorthiois, Edwige; Roache, James; Barnes-Seeman, David; Altmann, Eva; Hassiepen, Ulrich; Turner, Gordon; Duvadie, Rohit; Hornak, Viktor; Karki, Rajeshri G.; Schiering, Nikolaus; Weihofen, Wilhelm A.; Perruccio, Francesca; Calhoun, Amy; Fazal, Tanzina; Dedic, Darija; Durand, Corinne; Dussauge, Solene; Fettis, Kamal; Tritsch, Fabien; Dentel, Celine; Druet, Adelaide; Liu, Donglei; Kirman, Louise; Lachal, Julie; Namoto, Kenji; Bevan, Douglas; Mo, Rose; Monnet, Gabriela; Muller, Lionel; Zessis, Richard; Huang, Xueming; Lindsley, Loren; Currie, Treeve; Chiu, Yu-Hsin; Fridrich, Cary; Delgado, Peter; Wang, Shuangxi; Hollis-Symynkywicz, Micah; Berghausen, Joerg; Williams, Eric; Liu, Hong; Liang, Guiqing; Kim, Hyungchul; Hoffmann, Peter; Hein, Andreas; Ramage, Paul; D'arcy, Allan; Harlfinger, Stefanie; Renatus, Martin; Ruedisser, Simon; Feldman, David; Elliott, Jason; Sedrani, Richard; Maibaum, Juergen; Adams, Christopher M. [Journal of Medicinal Chemistry, 2020, vol. 63, # 15, p. 8088 - 8113]
  • 34
  • [ 878741-84-5 ]
  • [ 74-88-4 ]
  • 3-bromo-5-(2-cyanopropan-2-yl)benzoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
33% Stage #1: methyl 3-bromo-5-(cyanomethyl)benzoate With sodium hydride In tetrahydrofuran at 0℃; for 0.333333h; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran at 0 - 20℃; for 72h; Inert atmosphere; Stage #3: With sodium hydroxide In tetrahydrofuran; water at 20℃; for 16h;
Reference： [1]Lorthiois, Edwige; Roache, James; Barnes-Seeman, David; Altmann, Eva; Hassiepen, Ulrich; Turner, Gordon; Duvadie, Rohit; Hornak, Viktor; Karki, Rajeshri G.; Schiering, Nikolaus; Weihofen, Wilhelm A.; Perruccio, Francesca; Calhoun, Amy; Fazal, Tanzina; Dedic, Darija; Durand, Corinne; Dussauge, Solene; Fettis, Kamal; Tritsch, Fabien; Dentel, Celine; Druet, Adelaide; Liu, Donglei; Kirman, Louise; Lachal, Julie; Namoto, Kenji; Bevan, Douglas; Mo, Rose; Monnet, Gabriela; Muller, Lionel; Zessis, Richard; Huang, Xueming; Lindsley, Loren; Currie, Treeve; Chiu, Yu-Hsin; Fridrich, Cary; Delgado, Peter; Wang, Shuangxi; Hollis-Symynkywicz, Micah; Berghausen, Joerg; Williams, Eric; Liu, Hong; Liang, Guiqing; Kim, Hyungchul; Hoffmann, Peter; Hein, Andreas; Ramage, Paul; D'arcy, Allan; Harlfinger, Stefanie; Renatus, Martin; Ruedisser, Simon; Feldman, David; Elliott, Jason; Sedrani, Richard; Maibaum, Juergen; Adams, Christopher M. [Journal of Medicinal Chemistry, 2020, vol. 63, # 15, p. 8088 - 8113]
  • 35
  • [ 878741-84-5 ]
  • [ 74-88-4 ]
  • [ 878742-12-2 ]
  • 3-bromo-5-(2-cyanopropan-2-yl)benzoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: methyl 3-bromo-5-(cyanomethyl)benzoate With sodium hydride In tetrahydrofuran at 0℃; for 0.333333h; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran at 0 - 20℃; for 72h; Inert atmosphere;
Reference： [1]Lorthiois, Edwige; Roache, James; Barnes-Seeman, David; Altmann, Eva; Hassiepen, Ulrich; Turner, Gordon; Duvadie, Rohit; Hornak, Viktor; Karki, Rajeshri G.; Schiering, Nikolaus; Weihofen, Wilhelm A.; Perruccio, Francesca; Calhoun, Amy; Fazal, Tanzina; Dedic, Darija; Durand, Corinne; Dussauge, Solene; Fettis, Kamal; Tritsch, Fabien; Dentel, Celine; Druet, Adelaide; Liu, Donglei; Kirman, Louise; Lachal, Julie; Namoto, Kenji; Bevan, Douglas; Mo, Rose; Monnet, Gabriela; Muller, Lionel; Zessis, Richard; Huang, Xueming; Lindsley, Loren; Currie, Treeve; Chiu, Yu-Hsin; Fridrich, Cary; Delgado, Peter; Wang, Shuangxi; Hollis-Symynkywicz, Micah; Berghausen, Joerg; Williams, Eric; Liu, Hong; Liang, Guiqing; Kim, Hyungchul; Hoffmann, Peter; Hein, Andreas; Ramage, Paul; D'arcy, Allan; Harlfinger, Stefanie; Renatus, Martin; Ruedisser, Simon; Feldman, David; Elliott, Jason; Sedrani, Richard; Maibaum, Juergen; Adams, Christopher M. [Journal of Medicinal Chemistry, 2020, vol. 63, # 15, p. 8088 - 8113]

Tags: 878741-84-5 synthesis path| 878741-84-5 SDS| 878741-84-5 COA| 878741-84-5 purity| 878741-84-5 application| 878741-84-5 NMR| 878741-84-5 COA| 878741-84-5 structure

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