Alternatived Products of [ 878809-70-2 ]
Product Details of [ 878809-70-2 ]
CAS No. : | 878809-70-2 |
MDL No. : | MFCD08064044 |
Formula : |
C15H22BrN3O2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
356.26
|
Pubchem ID : | - |
Synonyms : |
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Safety of [ 878809-70-2 ]
Application In Synthesis of [ 878809-70-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 878809-70-2 ]
- 1
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[ 13061-96-6 ]
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[ 1223432-03-8 ]
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[ 878809-70-2 ]
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[ 1223431-92-2 ]
- 2
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[ 878809-70-2 ]
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[ 849052-26-2 ]
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[ 1223432-24-3 ]
Yield | Reaction Conditions | Operation in experiment |
|
With potassium phosphate;(bis(tricyclohexyl)phosphine)palladium(II) dichloride; In water; toluene; for 8h;Reflux; |
To a mixture of 4-(5-bromo-3-methylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (4.8 g), bis(tricyclohexylphosphine)palladium (II) dichloride (515 mg), tripotassium phosphate (16 g) and <strong>[849052-26-2]cyclobutylboronic acid</strong> (2.6 g) were added toluene (39 mL) and water (2 mL), and the mixture was refluxed for 8 hr. After cooling, the mixture was extracted with ethyl acetate, washed with saturated brine, and the solvent was evaporated. The residue was purified by column chromatography (hexane:ethyl acetate) to give 4-(5-cyclobutyl-3-methylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (560 mg). 4-(5-cyclobutyl-3-methylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (560 mg) was dissolved in chloroform (1.5 mL), 4N hydrogen chloride/ethyl acetate (1.5 mL) was added, and the mixture was stirred at room temperature overnight. To the reaction mixture was added 1N aqueous sodium hydroxide solution (8 mL), and the mixture was extracted with chloroform. The organic layer was washed with saturated brine, and the solvent was evaporated to give the title compound (350 mg). |