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[ CAS No. 87988-94-1 ] {[proInfo.proName]}

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Chemical Structure| 87988-94-1
Chemical Structure| 87988-94-1
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Product Details of [ 87988-94-1 ]

CAS No. :87988-94-1 MDL No. :MFCD11848435
Formula : C4H6N2O Boiling Point : -
Linear Structure Formula :- InChI Key :QGMHRTDVNDXDBB-UHFFFAOYSA-N
M.W : 98.10 Pubchem ID :13033202
Synonyms :

Safety of [ 87988-94-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280 UN#:N/A
Hazard Statements:H302-H312-H332 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 87988-94-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 87988-94-1 ]

[ 87988-94-1 ] Synthesis Path-Downstream   1~22

  • 1
  • [ 87988-94-1 ]
  • [ 100-52-7 ]
  • benzylidene-(5-methyl-isoxazol-4-yl)-amine [ No CAS ]
  • 2
  • [ 87988-94-1 ]
  • [ 121-60-8 ]
  • [ 858490-50-3 ]
  • 4
  • [ 87988-94-1 ]
  • [ 463-71-8 ]
  • [ 122686-02-6 ]
  • 5
  • [ 87988-94-1 ]
  • [ 100-52-7 ]
  • [ 742021-43-8 ]
  • 7
  • [ 87988-94-1 ]
  • [ 98818-51-0 ]
  • [ 149976-33-0 ]
  • 8
  • N-(5-methyl-4-isoxazolyl)-4-amino-1,2-naphthoquinone [ No CAS ]
  • [ 87988-94-1 ]
  • [ 83-72-7 ]
  • 9
  • [ 87988-94-1 ]
  • [ 521-24-4 ]
  • 2-(5-Methyl-4-isoxazolylamino)-N-(5-methyl-4-isoxazolyl)-1,4-naphthoquinone-4-imine [ No CAS ]
  • 10
  • [ 87988-94-1 ]
  • [ 543-24-8 ]
  • [ 1026071-19-1 ]
  • 11
  • [ 87988-94-1 ]
  • [ 120-92-3 ]
  • [ 600699-45-4 ]
YieldReaction ConditionsOperation in experiment
5-Methyl-l,2-oxazol-4-amine hydrochloride (20 g), cyclopentanone (13.9 ml) and sodium acetate (12.3 g) were added to MeOH (200 ml) and stirred at O0C for 1 hr. NaCNBH3 (11.5 g) was slowly added over 20 mins, whilst maintaining the temperature below O0C. After complete addition the reaction mixture was warmed to ambient temperature and stirred for 16 hrs before the solvent was removed in vacuo. The solid obtained was dissolved in saturated aq. NH4Cl (100 ml) and extracted with ether (2 x 200 ml then 1 x 100 ml). The combined <n="114"/>organic extracts were dried, filtered and the solvent removed in vacuo to give a yellow oil. The oil was purified by column chromatography on silica using 10-50% ether in isohexane as eluent. The solvent was removed in vacuo to give the title compound as a yellow oil (17.2 g). NMR (300.072 MHz, CDCl3) 1.37-1.47 (m, 2H), 1.54-1.79 (m, 4H), 1.83-1.94 (m, 2H), 2.31 (s, 3H), 3.51 (quintet, IH), 8.03 (s, IH); m/z 167.
  • 12
  • [ 29943-42-8 ]
  • [ 87988-94-1 ]
  • C9H14N2O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Example 7 fa) 4-[N-Acetyl-N-(tetrahydro-2H-pyran-4-yl)]amino-5-methylisoxazole; 5-Methyl-4-amino-isoxazole (Reiter, L.A., J. Org. Chem. 1987, 52, 2714-2726) (0.68 g, 5.1 mmol) and acetic acid (0.61 g, 10.2 mmol) were dissolved in MeOH (20 mL). Tetrahydro-2H-pyran-4-one (0.76 g, 7.6 mmol) was added and the mixture was cooled to 0 - (-5) 0C and stirred for 1 h. Sodium cyanoborohydride (0.32 g, 5.1 mmol) was added to the reaction mixture at -5 0C, causing weak exothermic and gas evolution. The cooling bath was removed and the mixture was stirred at r.t. for 1 h, followed by the addition of a <n="42"/>second portion of sodium cyanoborohydride (0.1 g, 1.6 mmol). After stirring for 2 h at r.t, the mixture was filtered and the filtrate was concentrated in vacuo. The residue was dissolved in toluene and re-concentrated. The residue was dissolved in THF (10 mL) and acetic anhydride (1.56 g, 15.3 mmol) was added. The resulting mixture was stirred overnight at r.t. then for 1 h at +50 C. The volatiles were removed in vacuo and the residue was dissolved in toluene and concentrated in vacuo to give the title compound (1.36 g, 78%).1H NMR (CDCl3) ppm delta 8.04 (s, 1 H), 4.86-4.73 (m, 1 H), 4.00-3.89 (m, 2 H), 3.52-3.42 (m, 2 H), 2.35 (s, 3 H), 1.81 (s, 3 H), 1.70-1.57 (m, 2 H), 1.49-1.23 (m, 2 H); MS (ESI) m/z 225 (M+l).; Example 9(a) 5-Acetyl-l-(tetrahydro-2H-pyran-4-yl)- 2-trtfluoromethyl-lH-imidazole; 5-Methyl-4-amino-isoxazole (1.7 g, 17.25 mmol) and acetic acid (1.1 g, 19 mmol) were dissolved in methanol (50 mL). Tetrahydro-2H-pyran-4-one (1.9 g, 19 mmol) was added and the mixture was cooled to 0 - (-5) C and stirred for 1 h. Sodium cyanoborohydride (0.812 g, 12.9 mmol) was added in portions to the reaction mixture at -5 C, causing weak exothermic and gas evolution. The cooling bath was removed and the mixture was stirred at r.t. for 2 h followed by addition of water (20 mL). The methanol was removed from the reaction mixture by vacuum distillation, and the intermediate amine was extracted with ethyl acetate (3x80 mL). The combined organic layers were dried (Na2SO4), concentrated to dryness, dissolved in toluene and re-concentrated. The crude intermediate amine, was dissolved in CH2Cl2 (20 mL) and pyridine (2 mL, 26 mmol) was added. The mixture was cooled to 0C and trifluoroacetic anhydride (4.35 g, 20.7 mmol) was added dropwise. The mixture was continued stirring for 2 h at r.t and was then washed with water and saturated NaHCO3. The aqueous layer was extracted with CH2Cl2 (2x30 mL), the organic extracts were dried (Na2SO4) and concentrated to dryness to give a second crude intermediate, 4- [iV-(tetrahydro-2H-pyran-4-yl)]-iV-trifluoroacetyl-amino-5-methylisoxazole. MS (ES) m/z 279 (M++l). The title compound was prepared in accordance with the general method of Example 6(b) using the intermediate 4-[N-(tetrahydro-2H-pyran-4-yl)]-N-trifluoroacetyl- <n="47"/>amino-5-methylisoxazole (max 17.25 mmol), with the exception that the product was purified by flash chromatography (heptane/EtOAc 3:2), giving the title compound (3.03 g,1H NMR (CDCl3, 300 MHz) delta 7.85 (s, 1 H), 4.89-4.75 (m, 1 H), 4.17-4.07 (m, 2 H), 3.54- 3.44 (m, 2 H), 2.75-2.60 (m, 2 H), 2.56 (s, 3 H), 1.72-1.63 (m, 2 H); MS (ES) m/z 263 (M+l).
Example 8(a) 5-Acetyl-l-(tetrahydro-2H-pyran-4-yl)- 2-trifluoromethyl-lH-imidazole; 5-Methyl-4-amino-isoxazole (1.7 g, 17.25 mmol) and acetic acid (1.1 g, 19 mmol) were dissolved in methanol (50 mL). Tetrahydro-2H-pyran-4-one (1.9 g, 19 mmol) was added and the mixture was cooled to 0 - (-5) 0C and stirred for 1 h. Sodium cyanoborohydride (0.812 g, 12.9 mmol) was added in portions to the reaction mixture at -5 C, causing weak exothermic and gas evolution. The cooling bath was removed and the mixture was stirred at r.t. for 2 h followed by addition of water (20 mL). The methanol was removed from the reaction mixture, and the intermediate amine was extracted with ethyl acetate (3x80 mL). The combined organic layers were dried (Na2SO4), concentrated to dryness, dissolved in toluene and re-concentrated. The crude intermediate amine, was dissolved in CH2Cl2 (20 mL) and pyridine (2 mL, 26 mmol) was added. The mixture was cooled to 0C and trifluoroacetic anhydride (4.35 g, 20.7 mmol) was added dropwise. The mixture was continued stirring for 2 h at r.t. and was then washed with water and saturated NaHCO3. The aqueous layer was extracted with CH2Cl2 (2x30 mL), the organic extracts were dried (Na2SO4) and concentrated to dryness to give a second crude intermediate, 4-[N- (tetrahydro-2H-pyran-4-yl)]-N-trifluoroacetyl-amino-5-methylisoxazole. MS (ES) m/z 279 (M++.). The title compound was prepared in accordance with the general method of Example 6 (b) using the intermediate 4-[N-(tetrahydro-2H-pyran-4-yl)]-N-trifluoroacetyl- amino-5-methylisoxazole (max 17.25 mmol), with the exception that the product was purified by flash chromatography (heptane/EtOAc 3:2), giving the title compound (3.03 g, 67%).1H nuMR (CDCl3, 300 MHz) delta 7.85 (s, 1 H), 4.89-4.75 (m, 1 H), 4.17-4.07 (m, 2 H), 3.54- 3.44 (m, 2 H), 2.75-2.60 (m, 2 H), 2.56 (s, 3 H), 1.72-1.63 (m, 2 H); MS (ES) m/z 263 (M+l).
  • 13
  • [ 87988-94-1 ]
  • [ 851847-26-2 ]
  • 4-methyl-N-(5-methylisoxazol-4-yl)-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; HATU; In N,N-dimethyl-formamide; at 20℃; for 16h; To a stirred slurry of 4-methyl-3-[6-(4-methylpiperazm-l-yl)-4-oxoquinazolin-3(4H)-yl]benzoic acid (0.38 g) in DMF (50 ml) was added <strong>[87988-94-1]4-amino-5-methylisoxazole</strong> hydrochloride (0.27 g), EtaATU (0.68 g) and triethylamine (0.55 ml) and the reaction mixture stirred at room temperature for 16 hours. The reaction mixture was diluted with water and extarcted with ethyl acetate. The ethyl aceate layer was washed with IN NaOH and dried (magnesium sulphate). The residue was purified by column chromatography on a silica column using initially ethyl acetate and then a 4: 1 mixture of ethyl acetate and methanol as eluent. There was thus obtained the title compound (150 mg); NMR Spectrum: (DMSOd6) 2.15 (s, 3Eta), 2.40 (s, 3H), 2.83 (m, 4H), 3.15 (s, 3H), 3.40 (m, 4H), 7.50 (d, IH), 7.60 (d, IH), 7.64 (m, 2H), 7.98 (s, IH), 8.04 (d, IH), 8.13 (s, IH), 8.70 (s, IH), 10.10 (s, IH); Mass Spectrum: M+H+ 459.The <strong>[87988-94-1]4-amino-5-methylisoxazole</strong> hydrochloride used as starting material was prepared using the procedures detailed in J. Org. Chem 1987, 2714-2716.
  • 14
  • [ 87988-94-1 ]
  • [ 288606-09-7 ]
  • [ 354795-10-1 ]
YieldReaction ConditionsOperation in experiment
In n-heptane; EXAMPLE 2 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (3-methylisoxazole-4-yl)-amide Starting from 4-difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (150 mg) and 5-methylisoxazol-4-ylamine (60 mg). Purification by column chromatography on silica eluding with 50% ethyl acetate in heptane afforded the title compound as a white solid (110 mg). TLC Rf 0.32 (ethyl acetate). M.p. 103-104.5 C.
  • 15
  • [ 87988-94-1 ]
  • [ 67-64-1 ]
  • [ 403793-46-4 ]
YieldReaction ConditionsOperation in experiment
5-Methyl-4-amino-isoxazole (Reiter, L. A., J. Org. Chem. 1987, 52, 2714-2726) (0.68 g, 5.1 mmol) and acetic acid (0.61 g, 10.2 mmol) were dissolved in MeOH (20 mL). Acetone (0.56 ml, 7.6 mmol) was added and the mixture was cooled to 0 - (-5) C and stirred for 1 h. Sodium cyanoborohydride (0.32 g, 5.1 mmol) was added to the reaction mixture at -5 0C, causing weak exothermic and gas evolution. The cooling bath was removed and the mixture was stirred at r.t. for 1 h, followed by the addition of a second portion of sodium cyanoborohydride (0.1 g, 1.6 mmol). After stirring for 2 h at r.t., the mixture was filtered and the filtrate was concentrated in vacuo. The residue was dissolved in toluene and re- concentrated. The residue was dissolved in THF (10 mL) and trifiuoro acetic anhydride (3.2 g, 15.3 mmol) was added. The resulting mixture was stirred overnight at r.t. then for 1 h at +50 0C. The volatiles were removed in vacuo and the residue was dissolved in toluene and concentrated in vacuo to give the title compound (0.84 g , 77 %) as a solid.1H NMR (400 MHz, CDCl3) delta ppm 8.11 (s, 1 H) 4.82 - 5.03 (m, 1 H) 2.39 (s, 3 H) 1.16 (d, J=6.82 Hz, 3 H) 1.08 (d, J=6.82 Hz, 3 H); MS (CI) m/z 236 (M+).
  • 16
  • [ 87988-94-1 ]
  • [ 67-64-1 ]
  • [ 407-25-0 ]
  • [ 934280-90-7 ]
YieldReaction ConditionsOperation in experiment
77% Example 15(a)2,2,2-Trifluoro-N-isopropyl-N-(5-methyl-isoxazol-4-yl)-acetamide 5-Methyl-4-amino-isoxazole (Reiter, L. A., J. Org. Chem. 1987, 52, 2714-2726) (0.68 g, 5.1 mmol) and acetic acid (0.61 g, 10.2 mmol) were dissolved in MeOH (20 mL). Acetone (0.56 ml, 7.6 mmol) was added and the mixture was cooled to 0-(-5) C. and stirred for 1 h. Sodium cyanoborohydride (0.32 g, 5.1 mmol) was added to the reaction mixture at -5 C., causing weak exothermic and gas evolution. The cooling bath was removed and the mixture was stirred at r.t. for 1 h, followed by the addition of a second portion of sodium cyanoborohydride (0.1 g, 1.6 mmol). After stirring for 2 h at r.t., the mixture was filtered and the filtrate was concentrated in vacuo. The residue was dissolved in toluene and re-concentrated. The residue was dissolved in THF (10 mL) and trifluoro acetic anhydride (3.2 g, 15.3 mmol) was added. The resulting mixture was stirred overnight at r.t. then for 1 h at +50 C. The volatiles were removed in vacuo and the residue was dissolved in toluene and concentrated in vacuo to give the title compound (0.84 g, 77%) as a solid.1H NMR (400 MHz, CDCl3) delta ppm 8.11 (s, 1H) 4.82-5.03 (m, 1H) 2.39 (s, 3H) 1.16 (d, J=6.82 Hz, 3H) 1.08 (d, J=6.82 Hz, 3H); MS (CI) m/z 236 (M+).
  • 17
  • [ 87988-94-1 ]
  • [ 1885-14-9 ]
  • [ 1190843-60-7 ]
YieldReaction ConditionsOperation in experiment
64% With pyridine; In tetrahydrofuran; at 0 - 20℃; To a solution of <strong>[87988-94-1]4-amino-5-methylisoxazole</strong> (2.00 g, 20.39mmol; CASNo. 87988-94-1) in THF (50 mL) at 0 0C was added pyridine (1.65 mL, 20.39 mmol) followed by phenyl chloroformate (2.81 mL, 22.43 mmol). After stirring at 0 0C for 2.5 h, the reaction was warmed to room temp overnight. The reaction was diluted with ethyl acetate and washed with 2M HCI, water, saturated sodium bicarbonate, and brine. The organic layer was dried over magnesium sulfate, filtered, concentrated, and purified by flash chromatography (ethyl acetate (5% ethanol)/ heptanes) to give the title compound as a white solid (2.85 g, 13.07 mmol, 64%).
64% With pyridine; In tetrahydrofuran; at 0 - 20℃; To a solution of <strong>[87988-94-1]4-amino-5-methylisoxazole</strong> (2.00 g, 20.39mmol; CASNo. 87988-94-1) in THF (50 mL) at 0 0C was added pyridine (1.65 mL, 20.39 mmol) followed by phenyl chloroformate (2.81 mL, 22.43 mmol). After stirring at 0 0C for 2.5 h, the reaction was warmed to room temp overnight. The reaction was diluted with ethyl acetate and washed with 2M HCI1 water, saturated sodium bicarbonate, and brine. The organic30 layer was dried over magnesium sulfate, filtered, concentrated, and purified by flash chromatography (ethyl acetate (5% ethanol)/ heptanes) to give the title compound as a white solid (2.85 g, 13.07 mmol, 64%).
64% With pyridine; In tetrahydrofuran; at 0 - 20℃; To a solution of <strong>[87988-94-1]4-amino-5-methylisoxazole</strong> (2.00 g, 20.39mmol; CASNo. 87988-94-1 ) in THF (50 mL) at 0 0C was added pyridine (1.65 mL, 20.39 mmol) followed by phenyl chloroformate (2.81 mL, 22.43 mmol). After stirring at 0 0C for 2.5 h, the reaction was warmed to room temp overnight. The reaction was diluted with ethyl acetate and washed with 2M HCI, water, saturated sodium bicarbonate, and brine. The organic layer was dried over magnesium sulfate, filtered, concentrated, and purified by flash chromatography (ethyl acetate (5% ethanol)/ heptanes) to give the title compound as a white solid (2.85 g, 13.07 mmol, 64%).
64% With pyridine; In tetrahydrofuran; at 0 - 20℃; To a solution of <strong>[87988-94-1]4-amino-5-methylisoxazole</strong> (2.00 g, 20.39mmol; CASNo. 87988-94-1 ) in THF (50 mL) at 0 C was added pyridine (1.65 mL, 20.39 mmol) followed by phenyl chloroformate (2.81 mL, 22.43 mmol). After stirring at 0 0C for 2.5 h, the reaction was warmed to room temp overnight. The reaction was diluted with ethyl acetate and washed with 2M HCI, water, saturated sodium bicarbonate, and brine. The organic layer was dried over magnesium sulfate, filtered, concentrated, and purified by flash chromatography (ethyl acetate (5% ethanol)/ heptanes) to give the title compound as a white solid (2.85 g, 13.07 mmol, 64%).

  • 18
  • [ 87988-94-1 ]
  • [ 1237517-77-9 ]
  • [ 1285514-42-2 ]
YieldReaction ConditionsOperation in experiment
A mixture of 2-[{phenyimethyl)oxy]-5-(4-pyridinyl)benzoic acid (may be prepared as described in Description 79; 100 mg, 0.30 mmol), EDC (115 mg, 0.60 mmol), and HOBT (92 mg, 0.60 mmol) in dimethylformamide (2 ml) was stirred in air at room temperature for 1 h, then 5-methyl-4-isoxazolamine (may be prepared as described in Description 93; 100 mg, 1.02 mmoi) was added in one charge. The reaction mixture was stirred at 25 C overnight. The solution was heated at 35C for 7 hours, then diluted with water (30 ml) and extracted with ethyl acetate (80 ml x 3). The organic phase was washed with brine (60 ml x 2), dried over anhydrous MgS04, and concentrated. The residue was purified bychromatography (silica gel, 20 g, eluent: dichloromethane/methanol = 60:1 , 600 ml). The crude product was washed with methanol (2 ml x 2), filtered, and dried in vacuum to yield the title compound. 23 mg.1HN R (400 MHz, DMSO-c/6): 9.95 (s, H), 8.82 (s, H), 8.62 (d, 2H, J=6.4), 8.10 (d, 1 H, J=2.4), 8.00 (dd, 1 H, J=2.0, J=8.4), 7.74 (dd, 2H, J=1.2, 4.8), 7.54 (d, 2H, J=7.2), 7.44-7.34 (m, 4H), 5.33 (s, 2H), 2.22 (s, 3H).MS (electrospray): m/z [M+H]+ = 386.1
  • 19
  • [ 87988-94-1 ]
  • [ 1285517-57-8 ]
  • [ 1285515-77-6 ]
YieldReaction ConditionsOperation in experiment
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; for 16h; A mixture of 2-[(4-f.uorop enyl)methyl]oxy}-5-(1-methyl-1 H-pyrazol-4-yl)benzoic acid (may be prepared as described in Description 121 ; 80 mg, 0.25 mmol), 3- methylisoxazol-4-amine (49.5 mg, 0.37 mmol), HOBT (56.3 mg, 0.37 mmol) and EDC (70.5 mg, 0.37 mmol) in N,N-dimethylformamide (2 ml) was stirred at room temperature for 16 hours. Water (50 ml) was added. A white precipitate was filtered, washed with ethyl acetate, and dried in vacuo to yield the title compound as a white solid. 54 mg, 1HNMR (400 MHz, DMSO-c 6): 1 .99 (3H, s), 3.86 (3 H, s), 5.25 (2 H, s), 7.25 (2H, t, J= 8.8 Hz), 7.32 (2H, d, J = 8.4 HZ), 7.59-7.62 ( H, q, J = 2.8, J = 8.8), 7.73-7.75 ( H, dd, J = 2.4 Hz, J = 8.4 Hz), 7.88 (1 H, s), 7.92 (1 H, d, J = 2.4), 8.16 (1 H, s), 9.17 (1 H, s), 9.88 (1 H, s)MS (electrospray): m/z [M+H]+ =407.1
  • 20
  • [ 1285517-13-6 ]
  • [ 87988-94-1 ]
YieldReaction ConditionsOperation in experiment
HCI gas in ethanol (5 ml, 6.50 mmol) was added into 1 ,1-dimethylethyl (5-methyl-4- isoxazolyl)carbamate (may be prepared as described in Description 92; 161 mg, 0.81 mmol) carefully in ice-water bath. The solution was stirred at room temperature for 2 hours. The reaction mixture was concentrated to and the residue was dissolved in water (10 ml). 30% Aqueous ammonia solution was added to adjust the pH to 9. The solution was then concentrated to yield the title compound as a yellow solid. 142 mg.
  • 21
  • [ 87988-94-1 ]
  • [ 76-05-1 ]
  • [ 103747-74-6 ]
YieldReaction ConditionsOperation in experiment
2.48 g at 20℃; for 0.666667h; (1) To <strong>[87988-94-1]5-methyl-1,2-oxazol-4-amine</strong> (1.78 g) was added anhydrous trifluoroacetic acid (18 mL), and the mixture was stirred at room temperature for 40 minutes. The reaction solution was treated azeotropically with toluene, and the resulting residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=87/13?67/33) to give 2,2,2-trifluoro-N-(5-methyl-1,2-oxazol-4-yl)acetamide (2.48 g). APCI-MS m/z: 195 [M+H]+.
  • 22
  • [ 87988-94-1 ]
  • [ 1027545-48-7 ]
  • 5-methyl-N-[[2-(trifluoromethyl)-4-pyridyl]methyl]isoxazol-4-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
68 mg With N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; at 20℃; for 16h; To a solution of 4-(chloromethyl)-2-(trifluoromethyl)pyridine (97.8 mg, 1 equiv.), 5- methylisoxazol-4-amine (49.1 mg, 1 equiv.), sodium iodide (225 mg, 3 equiv.) and DIPEA (0.261 mL, 3 equiv.) were added. The reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was filtered and concentrated in vacuo to yield the crude product. The obtained residue was purified by flash chromatography on silica gel (eluting with DCM / 2.5% of MeOH in DCM gradient; 0-40 % of 2.5% of MeOH in DCM) to afford the expected product (68 mg). LCMS: MW (calcd): 257.21; MS (ES+, m/z): 258.06 [M+H]+.
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