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Chemical Structure| 880361-72-8 Chemical Structure| 880361-72-8

Structure of 880361-72-8

Chemical Structure| 880361-72-8

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Product Details of [ 880361-72-8 ]

CAS No. :880361-72-8
Formula : C8H12N2
M.W : 136.19
SMILES Code : CC1=CC=CN=C1CNC
MDL No. :MFCD05864507

Safety of [ 880361-72-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H315-H318-H335
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P330-P332+P313-P362-P403+P233-P405-P501
Class:8
UN#:2735
Packing Group:

Application In Synthesis of [ 880361-72-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 880361-72-8 ]

[ 880361-72-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 55589-47-4 ]
  • [ 74-89-5 ]
  • [ 880361-72-8 ]
YieldReaction ConditionsOperation in experiment
58% Methylamine ethanol solution was added to a solution of <strong>[55589-47-4]3-methyl-2-pyridinecarboxaldehyde</strong> (1 mmol, 121 mg, 1 eq) in methanol (2 mL) (300muL, 2mmol, 2eq), The mixture was stirred at room temperature for 2 h before sodium borohydride (38 mg, 1 mmol, 1 eq) was added. The mixture was stirred for a further 1 h. After the reaction is complete, add water to quench the reaction and distill off the methanol. The aqueous phase was extracted three times with dichloromethane. The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by column chromatography to give the title compound as a yellow oil (yield).
  • 2
  • [ 55589-47-4 ]
  • [ 593-51-1 ]
  • [ 880361-72-8 ]
YieldReaction ConditionsOperation in experiment
79% With sodium tris(acetoxy)borohydride; In methanol; 1,2-dichloro-ethane; To a 100 mL RBF was added 3-methylpicolinaldehyde (1 g, 8.26 mmol) and DCE (Volume: 40.0 ml, Ratio: 8). To the stirred solution was added methanamine hydrochloride (1.672 g, 24.77 mmol) in one portion. MeOH (Volume: 5 ml, Ratio: 1.000) was added followed by STAB-H (3.15 g, 14.86 mmol) in one portion and the reaction was allowed to stir overnight. The reaction was diluted with DCM and washed with 1 M NaOH, dried with Na2SO4, filtered and concentrated to afford N-methyl-1-(3-methylpyridin-2- yl)methanamine (0.890 g, 6.53 mmol, 79 % yield) which was sufficiently pure by 1H NMR. 1H NMR (400 MHz, CDCl3): delta = 8.37 (d, J= 4.4 Hz, 1H), 7.40 (d, J= 7.6 Hz, 1H), 7.05 (dd, J= 7.6, 4.8 Hz, 1H), 3.82 (s, 2H), 2.50 (s, 3H), 2.29 (s, 3H); LC/MS 75-95% MeOH in H2O over 3 minutes, rt = 0.491 at 254 nM, MS (+) 137.2
 

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