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Chemical Structure| 88105-20-8 Chemical Structure| 88105-20-8

Structure of 88105-20-8

Chemical Structure| 88105-20-8

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Product Details of [ 88105-20-8 ]

CAS No. :88105-20-8
Formula : C6H5IO2S
M.W : 268.07
SMILES Code : O=C(C1=CC(I)=CS1)OC

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Application In Synthesis of [ 88105-20-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 88105-20-8 ]

[ 88105-20-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 62224-16-2 ]
  • [ 88105-20-8 ]
YieldReaction ConditionsOperation in experiment
With copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; sodium iodide; In 1,4-dioxane; at 120℃; for 2h;Inert atmosphere; In a microwave vial under argon methyl 4-bromo- thiophene-2-carboxylate (1 g), copper-I-iodide (43 mg),(1 R,2R)-N,N?-dimethyl-cyclohexane- 1 ,2-diamine (64 mg)and sodium iodide (1.4 g) are suspended in 1,4-dioxane (5mE) and heated to 120 C. for 2 h. The mixture is cooled,partitioned between water and EtOAC and the phases are separated. The aqueous phase is extracted with EtOAC and the combined organic phases are washed with brine. After drying (Mg504) the solvents are evaporated in vacuo. The residue is chromatographed on silica gel (cyclohexane/ EtOAC 100:0-95:5) to give the title compound. LC (Method 1): tR=1.02 mm.
 

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