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methyl 3-(5-bromo-2-fluorophenyl)propanoate[ No CAS ]
[ 881189-58-8 ]
Yield
Reaction Conditions
Operation in experiment
90%
With methanol; sodium hydroxide; In tetrahydrofuran; at 20℃; for 3h;
Example 14C j00288j Example 14B (0.48 g, 1.838 mmol) was dissolved in THF (16.71 mL) and MeOH (1.67 1 mL). NaOH (2.022 mL, 2.022 mmol) was added at ambient temperature,and the reaction was stirred for 3 h. The reaction was concentrated in vacuo, and the residue was diluted with 1 N NaOH and washed twice with DCM. The aqueous layer was acidified with 1 N HC1 and extracted twice with EtOAc. The combined EtOAc layers were washed with brine, dried (Na2504), filtered, and concentrated in vacuo to yield Example 14C (0.408 g, 1.65 mmol, 90% yield). 1H NMR (400 MHz,CHLOROFORM-cl) oe ppm 7.33 (2 H, d, J=17.32 Hz), 6.92 (1 H, t, J=9. 16 Hz), 2.90 -3.07 (2 H, m), 2.70 (2 H, d, J=6.78 Hz).
3-(3-(4-(cyclopropylsulfonyl)-3-((methyl((2-(trimethylsilyl)ethoxy)carbonyl)amino)methyl)phenylamino)-3-oxopropyl)-4-fluorophenylboronic acid[ No CAS ]
2-(1-(bis(tert-butoxycarbonyl)amino)-4-fluoroisoquinolin-6-ylamino)-2-(3-(3-(4-(cyclopropylsulfonyl)-3-((methyl((2-(trimethylsilyl)ethoxy)carbonyl)amino)methyl)phenylamino)-3-oxopropyl)-4-fluorophenyl)acetic acid[ No CAS ]
2-(1-(bis(tert-butoxycarbonyl)amino)-4-fluoroisoquinolin-6-ylamino)-2-(3-(3-(4-(cyclopropylsulfonyl)-3-((methylamino)methyl)phenylamino)-3-oxopropyl)-4-fluorophenyl)acetic acid[ No CAS ]
[6-(16-cyclopropanesulfonyl-7-fluoro-13-methyl-3,12-dioxo-2,13-diaza-tricyclo[13.3.1.16,10]icosa-1(19),6,8,10(20),15,17-hexaen-11-ylamino)-4-fluoro-isoquinolin-1-yl]-bis(carbamic acid tert-butyl ester)[ No CAS ]
(S)-[6-(16-cyclopropanesulfonyl-7-fluoro-13-methyl-3,12-dioxo-2,13-diaza-tricyclo[13.3.1.16,10]icosa-1(19),6,8,10(20),15,17-hexaen-11-ylamino)-4-fluoro-isoquinolin-1-yl]-bis(carbamic acid tert-butyl ester)[ No CAS ]
(R)-[6-(16-cyclopropanesulfonyl-7-fluoro-13-methyl-3,12-dioxo-2,13-diaza-tricyclo[13.3.1.16,10]icosa-1(19),6,8,10(20),15,17-hexaen-11-ylamino)-4-fluoro-isoquinolin-1-yl]-bis(carbamic acid tert-butyl ester)[ No CAS ]
(R)-11-(1-amino-4-fluoro-isoquinolin-6-ylamino)-16-cyclopropanesulfonyl-7-fluoro-13-methyl-2,13-diaza-tricyclo[13.3.1.16,10]icosa-1(19),6,8,10(20),15,17-hexaene-3,12-dione trifluoroacetic acid salt[ No CAS ]
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