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[ CAS No. 881841-53-8 ]

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2D
Chemical Structure| 881841-53-8
Chemical Structure| 881841-53-8
Structure of 881841-53-8 *Storage: {[proInfo.prStorage]}

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Product Details of [ 881841-53-8 ]

CAS No. :881841-53-8MDL No. :MFCD20528192
Formula : C8H7BrN2O Boiling Point : -
Linear Structure Formula :-InChI Key :-
M.W :227.06Pubchem ID :-
Synonyms :

Computed Properties of [ 881841-53-8 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 881841-53-8 ]

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Application In Synthesis of [ 881841-53-8 ]

  • Downstream synthetic route of [ 881841-53-8 ]

[ 881841-53-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1013-88-3 ]
  • [ 881841-53-8 ]
  • [ 881841-59-4 ]
YieldReaction ConditionsOperation in experiment
56% With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 100℃; for 15h; 26.A To a solution of (5-bromoimidazo[1 ,2-a]pyridin-2-yl)methanol (1.00 g, 4.40 mmol), 2,2'-bis(diphenylphosphino)-1 ,1'-binapthyl (986 mg, 1.58 mmol), and cesium carbonate (4.30 g, 13.2 mmol) in toluene (20 mL) was added benzophenone imine (2.22 mL, 13.2 mmol) and palladium(ll) acetate (119 mg, 0.53 mmol). The reaction mixture was heated at 1000C for 15 hours, diluted with ethyl acetate, and washed with aqueous sodium bicarbonate. The organic layer was isolated, dried with magnesium sulfate, and filtered. The solvent was removed and the residue purified by flash chromatography (0-7.5% ammonium hydroxide-acetonitrile) to give 0.80 g (56% yield) {5- [(diphenylmethylidene)amino] imidazo[1 ,2-a]pyridin-2-yl}methanol. 1H- NMR (CDCI3): δ 7.88 (m, 2H), 7.69 (m, 1 H), 7.57 (m, 1 H), 7.47 (m, 2H), 7.38 (m, 1 H), 7.30 (m, 2H), 7.23 (m, 1H), 7.09 (m, 2H), 6.92 (m, 1 H), 5.67 (m, 1 H), 4.90 (s, 2H); MS m/z 328 (M+1 ).
  • 2
  • [ 878197-68-3 ]
  • [ 881841-53-8 ]
YieldReaction ConditionsOperation in experiment
42% With sodium tetrahydroborate; In methanol; at 0 - 20℃; for 4h; To a stirred solution of 5-bromoimidazo[1 ,2-a]pyridine-2-carbaldehyde (1.42 g, 6.31 mmol) in methyl alcohol (30 mL) cooled to O0C was added sodium borohydride (286 mg, 7.57 mmol). The mixture was stirred at room temperature for 4 hours, quenched with water, and extracted with ethyl acetate. The organic layer was dried with magnesium sulfate and concentrated to give 0.6 g (42% yield) 5-bromoimidazo[1 ,2- a]pyridin-2-yl)methanol as an orange solid. 1H-NMR (CDCI3): delta 7.76 (s, 1 H), 7.55 (d, 1 H), 7.09 (m, 1 H), 7.03 (dd, 1 H), 4.87 (s, 2H); MS m/z 227 (M+1 ).
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