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Chemical Structure| 88280-53-9 Chemical Structure| 88280-53-9

Structure of 88280-53-9

Chemical Structure| 88280-53-9

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Product Details of [ 88280-53-9 ]

CAS No. :88280-53-9
Formula : C11H14O3
M.W : 194.23
SMILES Code : C[C@@H](O)CC(OCC1=CC=CC=C1)=O

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Application In Synthesis of [ 88280-53-9 ]

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  • Downstream synthetic route of [ 88280-53-9 ]

[ 88280-53-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 100-39-0 ]
  • [ 13613-65-5 ]
  • [ 88280-53-9 ]
YieldReaction ConditionsOperation in experiment
82.6% In N,N-dimethyl-formamide; at 0 - 15℃; for 6h;Inert atmosphere; To a solution of <strong>[13613-65-5][(3R)-3-hydroxybutanoyl]oxysodium</strong> (3 g, 23.79 mmol, 1 equiv.) in DMF (40 mL) was added bromomethylbenzene (4.48 g, 26.17 mmol, 3.11 mL, 1 .1 equiv.) drop-wise at 0°C under N2.The reaction mixture was warmed to 15°C and stirred at 15°C for 6 h, at which time the residue was poured into water (80 mL). The aqueous phase was extracted with ethyl acetate (100 mL). The organic phase was washed with brine (80 mL), dried over anhydrous Na2504, filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography (Petroleum ether/Ethyl acetate1 :0, 5/1) to afford benzyl (3R)-3-hydroxybutanoate (3.82 g, 19.65 mmol, 82.60percent yield) as white oil.
 

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