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[ CAS No. 883738-19-0 ] {[proInfo.proName]}

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Chemical Structure| 883738-19-0
Chemical Structure| 883738-19-0
Structure of 883738-19-0 * Storage: {[proInfo.prStorage]}
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Product Details of [ 883738-19-0 ]

CAS No. :883738-19-0 MDL No. :MFCD16294542
Formula : C22H35BN2O4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 402.34 Pubchem ID :-
Synonyms :

Safety of [ 883738-19-0 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P305+P351+P338 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 883738-19-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 883738-19-0 ]

[ 883738-19-0 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 865314-27-8 ]
  • [ 73183-34-3 ]
  • [ 883738-19-0 ]
YieldReaction ConditionsOperation in experiment
90% With potassium acetate In N,N-dimethyl-formamide at 80℃; for 4h; 14b tert-Butyl 4-(3-bromobenzyl)piperazine-1-carboxylate (448 mg, 1.25 mmol), bis(pinacolato)diboron (352 mg, 1.38 mmol), potassium acetate (368 mg, 3.75 mmol), and [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (31 mg, 0.038 mmol) were combined in DMF (10 mL), and the reaction stirred at 80° C. under N2 for 4 h. The cooled solution was partitioned between EtOAc and water. Organics were washed with brine, dried (MgSO4), and concentrated in vacuo. Purification by silica gel chromatography (10% EtOAc/hexanes) gave 550 mg (90%) of the title compound as an oil. [M+H] calc'd for C22H36BN2O4, 403; found, 403.
  • 2
  • [ 57260-71-6 ]
  • [ 380151-86-0 ]
  • [ 883738-19-0 ]
YieldReaction ConditionsOperation in experiment
100% Example 123 1,1-Dimethylethyl 4-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}-1-piperazinecarboxylate Benzaldehye-3-pinacolboronate (Fluorochem) (32 g, 138 mmol) was stirred in 300 mL of dry DCM in a 2000 mL 3-necked flask under nitrogen. A solution of Boc-piperidine (38.5 g, 207 mmol) in 350 mL of dry DCM was added dropwise over 6 min (negligible exotherm). Acetic acid (8.82 mL, 154 mmol) was then added dropwise over 6 min and washed in with a little more dry DCM. The mixture was stirred at ambient temperature for about 2.5 h. Then sodium triacetoxyborohydride (58.7 g, 277 mmol) was added portionwise over 10 min with cooling in an ice water bath to keep reaction temp at 10-15 C. After all had been added, the mixture was stirred at ambient temperature under nitrogen overnight. After a total of 21 h the reaction mixture was poured slowly onto 800 mL water with stirring. Gas evolution was observed. The mixture was stirred at room temperature until gas evolution had subsided. The mixture was partitioned between dichloromethane and water and the aqueous layer extracted well with dichloromethane. The combined organics were washed with water, brine, dried (MgSO4), filtered and evaporated then put under high vacuum to give 57.8 g (104%) of a sticky white foam. Lab HPLC showed two major peaks: retention time 1.63 min (55%) and retention time 2.15 min (39%). LC-MS m/z 403 (M+H)+, 0.94-1.04 min (ret time-broad peak) [84% above named product] and m/z 320 (M+H)+, 0.65 min (ret time) [12% boronic acid product].
  • 3
  • [ 57260-71-6 ]
  • [ 214360-74-4 ]
  • [ 883738-19-0 ]
YieldReaction ConditionsOperation in experiment
75% With PS-NMM In tetrahydrofuran at 150℃; for 0.25h; Microwave irradiation; in air;
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