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Chemical Structure| 884487-29-0 Chemical Structure| 884487-29-0

Structure of 884487-29-0

Chemical Structure| 884487-29-0

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Product Details of [ 884487-29-0 ]

CAS No. :884487-29-0
Formula : C15H25NO5
M.W : 299.36
SMILES Code : O=C(N1CCC(C(OCC)=O)C(C(C)C1)=O)OC(C)(C)C
MDL No. :MFCD24467376

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Application In Synthesis of [ 884487-29-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 884487-29-0 ]

[ 884487-29-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 884487-29-0 ]
  • [ 57297-29-7 ]
  • tert-butyl 2-cyclopropyl-4-hydroxy-9-methyl-5,6,8,9-tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
64% With sodium ethanolate; In ethanol; for 3h;Heating / reflux; Step 2; Preparation of tert-butyl 2-cvclopropyl-4-hvdroxy-9-methyl-5,6,8,9- tetrahvdro-7/-/-pyrimido[4,5-d]azepine-7-carboxylate; [067] Sodium ethoxide solution (21 weight percent ethanol, 2.24 mL, 1.45 mmol) was added dropwise to a solution of 1- tert-butyl 4-ethyl 6-methyl-5-oxoazepane-1,4-dicarboxylate (290 mg, 0.97 mmol) in ethanol (6 mL). Cyclopropylcarbamidine hydrochloride (175 mg, 1.45 mmol) was added, and the mixture was heated at reflux for 3 h. The contents of the flask were cooled to rt, and the solvent was removed under reduced pressure. The residue was suspended in water and extracted with chloroform (2x). The organic layers were combined and concentrated to afford 200 mg (64percent) of crude product, which was EPO <DP n="21"/>used in the next step without further purification.
 

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