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Chemical Structure| 884510-86-5 Chemical Structure| 884510-86-5

Structure of 884510-86-5

Chemical Structure| 884510-86-5

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Product Details of [ 884510-86-5 ]

CAS No. :884510-86-5
Formula : C13H24N2O4
M.W : 272.34
SMILES Code : O=C(N1C[C@H](C(N(OC)C)=O)CCC1)OC(C)(C)C
MDL No. :MFCD08752610

Safety of [ 884510-86-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 884510-86-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 884510-86-5 ]

[ 884510-86-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 884510-86-5 ]
  • [ 27139-97-5 ]
  • [ 942143-07-9 ]
YieldReaction ConditionsOperation in experiment
To a solution of <strong>[27139-97-5]2-bromo-4-chloro-1-methylbenzene</strong> (53 g, 0.26mol) in anhydrous THF (600 mL) at -78 °C under nitrogen was added dropwise a solution of 2.5 M "-BuLi in hexane (103 mL, 0.26 mol). After stirring for 1 hr at -78 °C, a solution of the {R)-tert-b\\xtyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (67 g, 0.246 mol) in anhydrous THF (300 mL) was added dropwise. After addition, the reaction mixture was allowed to warm to rt and stirred for 2 hr. The mixture was quenched with saturated NH4Cl solution (500 mL) and extracted with ethyl acetate (3 *400 mL). The combined organic layers were washed with brine, dried over Na2SO4 and concentrated in vacuo to give crude (R)-tert-buty\\ 3-(5-chloro-2- methylbenzoyl)piperidine-1-carboxylate (86 g), which was used immediately in the next step without purification.
 

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