Alternatived Products of [ 885069-03-4 ]
Product Details of [ 885069-03-4 ]
CAS No. : | 885069-03-4 |
MDL No. : | MFCD11101035 |
Formula : |
C9H7BrO3
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
243.05
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 885069-03-4 ]
Application In Synthesis of [ 885069-03-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 885069-03-4 ]
- 1
-
[ 197577-35-8 ]
-
[ 885069-03-4 ]
Yield | Reaction Conditions | Operation in experiment |
|
With jones' reagent In acetone for 48h; Ambient temperature; |
|
- 2
-
[ 1914-60-9 ]
-
[ 885069-03-4 ]
Yield | Reaction Conditions | Operation in experiment |
|
With bromine; acetic acid; for 16h; |
2::iiii2-l2:4;;Dichj4^-rH3env1]^th3^.T..ikappa£i.iby^.ic acijilvdr.ocjikMiifc <n="44"/>Step I: To a ^oiuUon of 2,3~dihydro-ben-'.«fura«"2-carboxylic acid (510 mg} in glacial acetic acid (4 ni..,} is added bromine (497 mg} drapwise. After 36 hours, the reaction is quenched vyii water ( I fX) mi.) a;kappal 5 sodium bisulfite { 1 g) and extracted l.wsce with EtOAc ( HX> rat). The extracts are. concentrated in vacuo and dried under high vacuum io afford 5--bromo-:23-jijhvdj;o:.hgn/:ofuratau.--2-csfhoxyIk acid (S . ) mg) as a solid. MS: 24 . (M-f Hs, Ii NMR [300 MHz, (CD^SOJ: o 13.05 (Ui SK 7.4 ( I H. 8 i; 7,25 { 1 H, ): 6.8 (IB, m); 5.25 ( J H, qiota 3.55 OR dd); 3.25 ( IH, m). |
|
With bromine; In acetic acid; for 16h; |
To a solution of 2,3-dihydtauo-benzofuran-2-carboxylic acid (510 mg, 3.11 mmol) in glacial acetic acid (4 mL) is added bromine (497 mg, 3.11 mmol) dropwise. After 16 hours, the reaction is quenched with water (100 mL) and sodium bisulfite (1 g, 9.6 mmol) and extracted twice with EtOAc (100 mL). The extracts are concentrated in vacuo and dried under high vacuum to afford 5-bromo-2,3- dihvdro-benzofuran-2-carboxylic acid (811 mg) as a solid. MS: 241 (M+H), 1H NMR [300 MHz, (CDj)2SO]: delta 13.05 (IH, s); 7.4 (IH, s); 7.25 (IH, d); 6.8 (IH, m); 5.25 (IH, q), 3.55 (IH, dd); 3.25 (IH, m). |