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Chemical Structure| 885278-53-5 Chemical Structure| 885278-53-5

Structure of 885278-53-5

Chemical Structure| 885278-53-5

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Product Details of [ 885278-53-5 ]

CAS No. :885278-53-5
Formula : C10H10N2O3
M.W : 206.20
SMILES Code : O=C(C1=NNC2=C1C=CC(OC)=C2)OC
MDL No. :MFCD07371587
InChI Key :QCRFOISODBNEHE-UHFFFAOYSA-N
Pubchem ID :46863924

Safety of [ 885278-53-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P264-P270-P301+P312-P330

Application In Synthesis of [ 885278-53-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 885278-53-5 ]

[ 885278-53-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 67-56-1 ]
  • [ 52351-75-4 ]
  • [ 885278-53-5 ]
YieldReaction ConditionsOperation in experiment
10% General procedure: Similar to as described in General Procedure Z, 6-methoxy-2,3-dihydro- 1H-indole-2,3-dione was converted to the title compound as a yellow solid (600 mg, 10%). LC-MS (ES, m/z): 207 [M+H]; A solution of 2,3-dihydro-1H-indole-2,3-dione (1 eq.) and sodium hydroxide (1.1 eq.) in water was stirred for 5-30 mm at 25 C. Then a solution of sodium nitrite (1 1 eq.) in water and concentrated sulfuric acid (2 eq.) were added dropwise with stirring at 0.-10 C. After 5-30 mm a solution of SnC12 (2.5 eq.) in concentrated hydrochloric acid (15-30 eq.) was added slowly. After5 being stirred for 1--5 h at 25 C the reaction mixture was filtered and the solid was dissolved in methanol. Sulfuric acid (0.5-1 eq.) was added to the solution and the solution was heated to reflux overnight. The resulting mixture was concentrated under vacuum, diluted with water, extracted with ethyl acetate, dried over anhydrous sodium sulfate, and concentrated under vacuum to give the ester which may need further purification such as fresh chromatography.
 

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Related Functional Groups of
[ 885278-53-5 ]

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Esters

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Related Parent Nucleus of
[ 885278-53-5 ]

Indazoles

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