630-580-1088 sales@ambeed.com
Structure Search

List Search MOL Search Structure Search

0
Chemistry
Asymmetric Synthesis >>Chiral Building BlocksChiral Catalysts, Chiral Ligands and Chiral ReagentsChiral Resolution ReagentsBoronic acids/esters >>Aliphatic BoronsAromatic BoronsOther BoronsOxaborolesCatalysis Chemistry >>Achiral Crown LigandsC-H ActivationCarbon-Donor LigandsChiral Carbon LigandsChiral Crown LigandsChiral Olefin LigandsCross-CouplingCross-Coupling Using Transition Metal CatalystsDACH or Trost LigandsChemical Biology >>Conjugation Chemistry
GlycoscienceLinkers and CrosslinkersNucleic Acid ChemistryPEGylationPeptide ChemistryPhotolabile Protecting GroupHeterocyclic Building Blocks >>AcridinesAliphatic HeterocyclesAromatic HeterocyclesAzetidinesBenzimidazolesBenzisoxazolesBenzodioxansBenzofuransBenzothiazolesInorganic reagents >>Inorganic ReagentOrganic Building Blocks >>Acid AnhydridesAcyl Chlorides
AlcoholsAldehydesAliphatic Chain HydrocarbonsAliphatic Cyclic HydrocarbonsAlkenesAlkylsAlkynesOrganometallic Reagents >>Grignard ReagentsOrganoarsenicOrganobismuthOrganoboronOrganogermaniumOrganolithiumOrganomercuryOrganosiliconOrganotinSpecialty Synthesis >>Enzyme-Mediated SynthesisFluorous SynthesisIonic Liquids
Solid Supported SynthesisStains and Dyes >>Acid DyesAzoic DyesBasic DyesDirect DyesDisperse DyesDye IntermediatesMordant DyesOil DyesOther Stains and DyesSynthetic Reagents >>Acids and BasesC-C Bond FormationC-X Bond Formation (Halogen)C-X Bond Formation (Non-Halogen)Chelation and Complexation CompoundsCondensation AgentsCouplingDehydrating ReagentsFluorination Reagent
Pharmaceutical Intermediates
Analgesics >>BenzhydrocodoneBicifadineCapsaicinCelecoxibDebio-0827DexamethasoneElagolix SodiumEsketamine HydrochlorideIbuprofen SodiumAnesthetics >>CiprofolEsketamine HydrochlorideFospropofol Fospropofol DisodiumLevobupivacaine RemimazolamRemimazolam BesilateRemimazolam BesylateRopivacaineAnti-Addiction Agents >>Kakonein
Lofexidine HydrochlorideVarenicline Anti-inflammatory Agents >>ApremilastAsunaprevirATB-346 RelatedBalsalazide BaricitinibBencycloquidium BromideBudesonideCefiderocol Sulfate TosylateCeftaroline Fosamil AcetateAntibacterials >>AFN-1252 RelatedAlatrofloxacin Bedaquiline FumarateBesifloxacin BrilacidinCaspofungin AcetateCefiderocol Sulfate TosylateCefilavancinCeftaroline Fosamil
Anticonvulsants >>BrivaracetamCannabidiolEscitalopram OxalateEslicarbazepine Acetate RelatedFosphenytoinGabapentin EnacarbilJNJ-10234094LacosamideLevetiracetam RelatedAntidementia Agents >>Azeliragon RelatedDavunetideDonepezil HydrochlorideDonepezil RelatedEnsaculinFlorbetaben Flortaucipir F 18Flutemetamol IdalopirdineAntidepressants >>4-Chlorokynurenine
AgomelatineAgomelatine RelatedAllopregnanolone RelatedAmibegronAmitifadineAripiprazole RelatedBasimglurantBefloxatoneAntiemetics >>AprepitantAprepitant RelatedDolasetron RelatedDolasetron Mesylate HydrateFosaprepitant DimeglumineFosaprepitant RelatedOlanzapinePalonosetron RelatedPalonosetron HydrochlorideAntifungals >>Anidulafungin RelatedCabotegravirMore >>
Inhibitors/Agonists
ADC >>ADC AntibodyADC LinkerADC Linker with PayloadADC ToxinAntibody-Drug Conjugates (ADCs)Drug-Linker Conjugates for ADCAngiogenesis >>ALKBcr-AblBTKEGFRFAKFGFRFLT3HER2HIFAnti-infection >>3CLproAntibacterialAntibioticAntifungal
AntiparasiticAntiprotozoalAntiviralArenavirusBVDVApoptosis >>Apoptosis InducerBcl-2Bcl-6BRKc-Mycc-RETC/EBPCARDCaspaseAutophagy >>Atg4ATG4BATTECsAUTACsAutophagyBeclin1
FKBPLC3LRRK2Biochemical Reagent >>Cell Cycle >>AntifolateAPCAurora KinaseBUBCasein KinaseCdc25CDKChkCRISPR/Cas9Cytoskeleton >>ActinArp2/3 ComplexCYTHCytoplasmic DyneinDynaminFAKMore >>
Material Science
Aggregation-Induced Emission >>Other AIE BlocksTetraphenylethylene SeriesCOFs Linkers >>Aldehyde COFs LinkersAlkynyl COFs LinkersAmine COFs LinkersBoric COFs LinkersCyano COFs LinkersMultifunctional COFs linkersOther COFs linkersTriptycene SeriesElectronic Materials >>Battery MaterialsDye-Sensitized Solar Cell (DSSC) MaterialsElectronic MaterialLiquid Crystal (LC) MaterialsMolecular ConductorsOrganic Light-Emitting Diode (OLED) MaterialsOrganic Solar Cell (OPV) MaterialsOrganic Transistor (OFET) MaterialsPerovskite Solar Cell (PSC) MaterialsMagnetic Materials >>Magnetic Ionic LiquidsMagnetic MaterialMagnetic Metal Complexes
Organic Radicals Material Chemical Compounds >>Ligands for Functional Metal ComplexesLiquid Crystal (LC) Building BlocksPhthalocyanine Building BlocksPolymer and Macromolecule Semiconductor Building BlocksSmall Molecule Semiconductor Building BlocksSolubility Enhancing Reagents Supramolecular Host Materials MOF Ligands >>Carboxylic Acid MOF LigandsCarboxylic Acid Nitrogen-Containing Mixed MOF LigandsNitrogen-Containing MOF LigandsOther MOF LigandsNanomaterials >>Carbon NanomaterialsCeramic MembranesDendrimersGold NanoparticlesIron Oxide NanoparticlesMaterials by ApplicationMesoporous MaterialsMetals and Metal AlloysNano Minerals: NanoclaysOLED Materials >>Dopant
HostHTMOLED IntermediatesOther OLED related materialsOptical Materials >>Coumarin DyesCyanine and Squarylium DyesDCM DyesDipyrromethene DyesFluorescence MaterialsFluorescent ProbesHeat and Pressure Sensitive DyesNear-Infrared (NIR) DyesOrganic Non-Linear Optical (NLO) MaterialsOrganic Pigments >>Organic PigmentOther Materials >>Mateial OtherPolymer Science >>MonomersPolymer AdditivesPolymerization ReagentsPolymersResins
Contact Us
Home Cart 0 Sign in  
Chemistry
Heterocyclic Building Blocks
Piperazines
dimethylpiperazine
Benzyl 3,5-dimethylpiperazine-1-carboxylate
Chemistry
Heterocyclic Building Blocks
Organic Building Blocks
Piperazines
Aryls Amides Aliphatic Heterocycles
dimethylpiperazine

[ CAS No. 885278-83-1 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 885278-83-1
Chemical Structure| 885278-83-1
Structure of 885278-83-1 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 885278-83-1 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 885278-83-1 ]

SDS Specification
Alternatived Products of [ 885278-83-1 ]

Product Details of [ 885278-83-1 ]

CAS No. :885278-83-1 MDL No. :MFCD07371656
Formula : C14H20N2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 248.32 Pubchem ID :-
Synonyms :

Safety of [ 885278-83-1 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501 UN#:
Hazard Statements:H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 885278-83-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 885278-83-1 ]

[ 885278-83-1 ] Synthesis Path-Downstream   1~16

  • 1
  • [ 50-00-0 ]
  • [ 885278-83-1 ]
  • C20H31BN2O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol; water at 20℃; Step 1: 3,4,5-Trimethyl-piperazine-l-carboxylic acid benzyl ester Benzyl 3,5-dimethylpiperazine-l-carboxylate (1 eq, 2.04 mmol, 0.5 g) and formaldehyde (37% in H2O, 5eq, 10.07 mmol, 0.277 ml) are dissolved in MeOH (10 ml). After 10 mins at room temperature, acetic acid (5eq, 10.07 mmol, 0.576 ml) and sodium triacetoxyborohydride (5eq, 10.07 mmol , 2.13 g) are added and the reaction mixture stirred overnight. The reaction is quenched with 5M HCl (15 ml) and the solvent evaporated under vacuo. The residue is taken to pH 13 by addition of sodium hydroxide (4M) and extracted with EtOAc. This organic portion is washed with water and brine, dried over MgSθ4, filtered and concentrated in vacuo to afford the title compound.
Reference： [1]Current Patent Assignee: Novartis (w/o Sandoz); NOVARTIS AG - WO2009/87212, 2009, A2 Location in patent: Page/Page column 146
  • 2
  • [ 885278-83-1 ]
  • [ 4204-16-4 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: methanol; water / 20 °C 2.1: sodium tris(acetoxy)borohydride; acetic acid / methanol; water / 20 °C 2.2: pH 13 3.1: hydrogen / palladium on activated charcoal / ethanol / 4 h / 20 °C
Reference： [1]Current Patent Assignee: Novartis (w/o Sandoz); NOVARTIS AG - WO2009/87212, 2009, A2
  • 3
  • [ 885278-83-1 ]
  • [ 1171045-71-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: methanol; water / 20 °C 2.1: sodium tris(acetoxy)borohydride; acetic acid / methanol; water / 20 °C 2.2: pH 13
Reference： [1]Current Patent Assignee: Novartis (w/o Sandoz); NOVARTIS AG - WO2009/87212, 2009, A2
  • 4
  • [ 1207455-37-5 ]
  • [ 885278-83-1 ]
YieldReaction ConditionsOperation in experiment
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 4h; Inert atmosphere;
Reference： [1]Satish, Sohal; Chitral, Rohan; Kori, Amitkumar; Sharma, Basantkumar; Puttur, Jayashree; Khan, Afreen A.; Desle, Deepali; Raikuvar, Kavita; Korkegian, Aaron; Martis, Elvis A. F.; Iyer, Krishna R.; Coutinho, Evans C.; Parish, Tanya; Nandan, Santosh [Molecular Diversity, 2022, vol. 26, # 1, p. 73 - 96]
  • 5
  • [ 501-53-1 ]
  • [ 108-49-6 ]
  • [ 885278-83-1 ]
  • C14H20N2O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride In water for 48h;
Reference： [1]Satish, Sohal; Chitral, Rohan; Kori, Amitkumar; Sharma, Basantkumar; Puttur, Jayashree; Khan, Afreen A.; Desle, Deepali; Raikuvar, Kavita; Korkegian, Aaron; Martis, Elvis A. F.; Iyer, Krishna R.; Coutinho, Evans C.; Parish, Tanya; Nandan, Santosh [Molecular Diversity, 2022, vol. 26, # 1, p. 73 - 96]
  • 6
  • [ 120-57-0 ]
  • [ 885278-83-1 ]
  • C22H26N2O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane for 4h; Inert atmosphere; Reflux;
Reference： [1]Satish, Sohal; Chitral, Rohan; Kori, Amitkumar; Sharma, Basantkumar; Puttur, Jayashree; Khan, Afreen A.; Desle, Deepali; Raikuvar, Kavita; Korkegian, Aaron; Martis, Elvis A. F.; Iyer, Krishna R.; Coutinho, Evans C.; Parish, Tanya; Nandan, Santosh [Molecular Diversity, 2022, vol. 26, # 1, p. 73 - 96]
  • 7
  • [ 24424-99-5 ]
  • [ 885278-83-1 ]
  • [ 1207455-37-5 ]
YieldReaction ConditionsOperation in experiment
85% With triethylamine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;
Reference： [1]Satish, Sohal; Chitral, Rohan; Kori, Amitkumar; Sharma, Basantkumar; Puttur, Jayashree; Khan, Afreen A.; Desle, Deepali; Raikuvar, Kavita; Korkegian, Aaron; Martis, Elvis A. F.; Iyer, Krishna R.; Coutinho, Evans C.; Parish, Tanya; Nandan, Santosh [Molecular Diversity, 2022, vol. 26, # 1, p. 73 - 96]
  • 8
  • [ 885278-83-1 ]
  • 4-[(benzo[d][1,3]dioxol-5-yl)methyl]-N-benzyl-3,5-dimethylpiperazine-1-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 4 h / Inert atmosphere; Reflux 2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C 3: 1,2-dichloro-ethane / 20 °C / Inert atmosphere
Reference： [1]Satish, Sohal; Chitral, Rohan; Kori, Amitkumar; Sharma, Basantkumar; Puttur, Jayashree; Khan, Afreen A.; Desle, Deepali; Raikuvar, Kavita; Korkegian, Aaron; Martis, Elvis A. F.; Iyer, Krishna R.; Coutinho, Evans C.; Parish, Tanya; Nandan, Santosh [Molecular Diversity, 2022, vol. 26, # 1, p. 73 - 96]
  • 9
  • [ 885278-83-1 ]
  • C14H20N2O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 4 h / Inert atmosphere; Reflux 2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C
Reference： [1]Satish, Sohal; Chitral, Rohan; Kori, Amitkumar; Sharma, Basantkumar; Puttur, Jayashree; Khan, Afreen A.; Desle, Deepali; Raikuvar, Kavita; Korkegian, Aaron; Martis, Elvis A. F.; Iyer, Krishna R.; Coutinho, Evans C.; Parish, Tanya; Nandan, Santosh [Molecular Diversity, 2022, vol. 26, # 1, p. 73 - 96]
  • 10
  • [ 885278-83-1 ]
  • Benzyl (3S,5R)-4-(2-((3-amino-1-methyl-1H-indazol-7-yl)oxy)acetyl)-3,5-dimethylpiperazine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: triethylamine / Petroleum ether 2: potassium carbonate / Petroleum ether
Reference： [1]Current Patent Assignee: BRISTOL-MYERS SQUIBB CO - US2022/2273, 2022, A1
  • 11
  • [ 885278-83-1 ]
  • Benzyl (3S,5R)-4-(2-((3-amino-1-methyl-1H-indazol-7-yl)oxy)ethyl)-3,5-dimethylpiperazine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / Petroleum ether 2: potassium carbonate / Petroleum ether 3: Petroleum ether
Reference： [1]Current Patent Assignee: BRISTOL-MYERS SQUIBB CO - US2022/2273, 2022, A1
  • 12
  • [ 885278-83-1 ]
  • Benzyl (3S,5R)-4-(2-((3-((3-ethoxy-3-oxopropyl)amino)-1-methyl-1H-indazol-7-yl)oxy)ethyl)-3,5-dimethylpiperazine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / Petroleum ether 2: potassium carbonate / Petroleum ether 3: Petroleum ether
Reference： [1]Current Patent Assignee: BRISTOL-MYERS SQUIBB CO - US2022/2273, 2022, A1
  • 13
  • [ 885278-83-1 ]
  • Benzyl (3S,5R)-4-(2-((3-(1-(3-ethoxy-3-oxopropyl)ureido)-1-methyl-1H-indazol-7-yl)oxy)ethyl)-3,5-dimethylpiperazine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: triethylamine / Petroleum ether 2: potassium carbonate / Petroleum ether 3: Petroleum ether 5: potassium cyanate
Reference： [1]Current Patent Assignee: BRISTOL-MYERS SQUIBB CO - US2022/2273, 2022, A1
  • 14
  • [ 885278-83-1 ]
  • 1-(7-(2-((2S,6R)-2,6-Dimethylpiperazin-1-yl)ethoxy)-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1: triethylamine / Petroleum ether 2: potassium carbonate / Petroleum ether 3: Petroleum ether 5: potassium cyanate
Reference： [1]Current Patent Assignee: BRISTOL-MYERS SQUIBB CO - US2022/2273, 2022, A1
  • 15
  • [ 885278-83-1 ]
  • [ 79-04-9 ]
  • Benzyl (3S,5R)-4-(2-chloroacetyl)-3,5-dimethylpiperazine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine In Petroleum ether 15 Example 15 To a solution of (3S,5R)-benzyl 3,5-dimethylpiperazine-1-carboxylate (5.000 g, 20.14 mmol, 1 equiv.) in dichloromethane (50 mL) was added triethylamine (4.2 mL, 30.20 mmol, 1.5 equiv.) followed by 2-chloroacetyl chloride (1.76 mL, 22.15 mmol, 1.1 equiv.) drop-wise at 0° C. and the reaction mixture was stirred at 0° C. After 2 h the reaction solution was concentrated and purified by silica gel column chromatography (20-50% ethyl acetate in petroleum ether) to afford benzyl (3S,5R)-4-(2-chloroacetyl)-3,5-dimethylpiperazine-1-carboxylate (3.300 g, 10.16 mmol, 51% yield) as a white solid. 1H NMR (400 MHz, CDCl3) δ 7.41-7.34 (m, 5H), 5.19 (s, 2H), 4.60 (m, 1H), 4.16-4.07 (m, 5H), 3.07 (br, s, 2H), 1.32 (m, 6H).
Reference： [1]Current Patent Assignee: BRISTOL-MYERS SQUIBB CO - US2022/2273, 2022, A1
  • 16
  • [ 885278-83-1 ]
  • [ 109-64-8 ]
  • Benzyl (3R,5S)-4-(3-bromopropyl)-3,5-dimethylpiperazine-1-carboxylate [ No CAS ]
  • 4-(3-(trans-4-(2-((3S,5R)-4-(3-((3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-7-yl)oxy)propyl)-3,5-dimethylpiperazin-1-yl)ethoxy)cyclohexyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile hydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
28% With potassium carbonate 16 Example 16 To a solution of (3R,5S)-benzyl 3,5-dimethylpiperazine-1-carboxylate (5.000 g, 20.140 mmol, 1 equiv.) and 1,3-dibromopropane (40.65 g, 201.35 mmol, 10 equiv.) in acetonitrile (50 mL) was added potassium carbonate (8.350 g, 60.410 mmol, 3 equiv.) and the reaction mixture was stirred at 100° C. After 12 h the reaction solution was diluted with ethyl acetate (100 mL), filtered and concentrated. The resulting crude material was purified y silica gel column chromatography (25-50% ethyl acetate in petroleum ether) to give benzyl (3R,5S)-4-(3-bromopropyl)-3,5-dimethylpiperazine-1-carboxylate (2.000 g, 5.630 mmol, 28% yield) as a colorless oil. MS (ESI) m/z 371.0 [M+1]+; 1H NMR (400 MHz, CDCl3) δ 7.39-7.30 (m, 5H), 5.13 (s, 2H), 3.96-3.91 (m, 2H), 3.39-3.36 (t, J=6.4 Hz, 2H), 2.91-2.87 (m, 2H), 2.62-2.54 (m, 4H), 1.97-1.90 (m, 2H), 1.10-1.09 (d, J=5.2 Hz, 6H).
Reference： [1]Current Patent Assignee: BRISTOL-MYERS SQUIBB CO - US2022/2273, 2022, A1

Tags: 885278-83-1 synthesis path| 885278-83-1 SDS| 885278-83-1 COA| 885278-83-1 purity| 885278-83-1 application| 885278-83-1 NMR| 885278-83-1 COA| 885278-83-1 structure

Same Skeleton Products
Related Products
Categories
Chemistry
Heterocyclic Building Blocks
Piperazines
dimethylpiperazine
Chemistry
Organic Building Blocks
Aryls
Chemistry
Organic Building Blocks
Amides
Chemistry
Heterocyclic Building Blocks
Aliphatic Heterocycles
Historical Records