Alternatived Products of [ 885520-83-2 ]
Product Details of [ 885520-83-2 ]
CAS No. : | 885520-83-2 |
MDL No. : | MFCD08272208 |
Formula : |
C8H7BrN2O
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | OXGWZLFBKVMEGE-UHFFFAOYSA-N |
M.W : |
227.06
|
Pubchem ID : | 24728315 |
Synonyms : |
|
Safety of [ 885520-83-2 ]
Application In Synthesis of [ 885520-83-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 885520-83-2 ]
- 1
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[ 885520-83-2 ]
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4-benzyloxy-3-fluorophenylboronic acid
[ No CAS ]
-
[ 1056263-32-1 ]
Yield | Reaction Conditions | Operation in experiment |
|
With pyridine;copper diacetate; In dichloromethane; at 20.0℃; for 72.0h;Molecular sieve; |
Description 3; 4-Bromo-1-{3-fluoro-4-[(phenylm -(methyloxy)-1 H-indazole (D3)To a solution of 4-bromo-6-(methyloxy)-1 H-indazole (200 mg, 0.88 mmol) in dichloromethane (10 mL) was added 4-benzyloxy-3-fluorobenzeneboronic acid (433 mg, 1.76 mmol), pyridine (0.14 mL, 1.73 mmol), copper acetate (239 mg, 1.32 mmol) and powdered 4A molecular sieves (500 mg). The reaction mixture was stirred at room temperature in the presence of air for 3 days. Celite was added to the mixture then the mixture was filtered through a pad of celite and then the filtrate concentrated in vacuo. The product was purified by silica gel chromatography eluting with 5-80% dichloromethane in hexane to yield the title compound (D3) (176 mg). <n="18"/>LC-MS: MH+ = 427, 429 (C2IH16BrFN2O2 = 426, 428) |
- 2
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[ 110-87-2 ]
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[ 885520-83-2 ]
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[ 1425932-74-6 ]
Yield | Reaction Conditions | Operation in experiment |
100% |
With toluene-4-sulfonic acid; In tetrahydrofuran; for 18.0h;Inert atmosphere; Reflux; |
Referential Example 26 (6-Methoxy- 1 -(tetrahydro-2H-pyran-2-yl)- 1 H-indazol-4-yl)methanamine (129) step 1 : A round-bottom flask was charged with 4-bromo-6-methoxy-lH-indazole (1.00 g, 4.40 mmol), TsOH monohydrate (39 mg, 0.22 mmol), 3,4-dihydro-2H-pyran (1.48 g, 17.6 mmol), and THF (40 mL). The reaction mixture was degassed with nitrogen and refluxed for 18 h, and the solvent was then removed in vacuo. The residue was purified by S1O2 chromatography to afford 4-bromo-6-methoxy-l-(tetrahydro- 2H-pyran-2-yl)-lH-indazole (1.53 g, quantitative) as a yellow solid. MS (ESI) m/z: 311.2 [M+l]+. |
- 3
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[ 885520-83-2 ]
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[ 1425932-75-7 ]
- 4
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[ 885520-83-2 ]
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[ 1425932-76-8 ]
- 5
-
[ 885520-83-2 ]
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[ 98-80-6 ]
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C14H12N2O
[ No CAS ]
- 6
-
[ 885520-83-2 ]
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[ 1056261-67-6 ]
- 7
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[ 885520-83-2 ]
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[ 1056263-40-1 ]