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Chemical Structure| 886-46-4 Chemical Structure| 886-46-4

Structure of 886-46-4

Chemical Structure| 886-46-4

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Product Details of [ 886-46-4 ]

CAS No. :886-46-4
Formula : C13H19NO2
M.W : 221.30
SMILES Code : OC1C(CO)CN(CC2=CC=CC=C2)CC1
MDL No. :MFCD03940529

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Application In Synthesis of [ 886-46-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 886-46-4 ]

[ 886-46-4 ] Synthesis Path-Downstream   1~1

  • 1
  • Na2SO4.10H2O [ No CAS ]
  • [ 57611-47-9 ]
  • [ 886-46-4 ]
YieldReaction ConditionsOperation in experiment
In tetrahydrofuran; 1-Benzyl-3-hydroxymethyl-piperidin-4-ol (44B): To a solution of <strong>[57611-47-9]1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester</strong> (22.16 g, 0.47 mol) in THF (300 ml) at 0 C. was added dropwise a 1N solution of lithium aluminum hydride in THF (300 ml, 0.3 mol). After stirring at RT for 1 h, the reaction was heated at 80 C. for 2 h. After cooling to RT, the reaction was poured into 500 g of Na2SO4.10H2O. Filtration, washing with dichloromethane and evaporation then gave crude 1-benzyl-3-hydroxymethyl-piperidin-4-ol (16.42 g) that was used directly for the next step.
 

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