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[ CAS No. 886365-79-3 ]

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Chemical Structure| 886365-79-3
Chemical Structure| 886365-79-3
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Product Details of [ 886365-79-3 ]

CAS No. :886365-79-3 MDL No. :MFCD03646009
Formula : C7H10BrN3O Boiling Point : 330.6°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :232.08 g/mol Pubchem ID :3951894
Synonyms :

Safety of [ 886365-79-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 886365-79-3 ]

  • Upstream synthesis route of [ 886365-79-3 ]
  • Downstream synthetic route of [ 886365-79-3 ]

[ 886365-79-3 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 32779-36-5 ]
  • [ 109-85-3 ]
  • [ 886365-79-3 ]
YieldReaction ConditionsOperation in experiment
92.3% With potassium carbonate In acetonitrile at 100℃; for 6 h; To a solution of 5-bromo-2-chloropyrimidine (4 g, 20.68 mmol) in acetonitrile (40 mL) was added 2-methoxyethanamine (5.5 mL, 63 mmol) and potassium carbonate (14 g, 100 mmol) . The mixture was heated at 100 and stirred for 6 h. The reaction mixture was concentrated to remove solvent. The residue was diluted with water (30 mL) . The resulting mixture was extracted with DCM (50 mL × 3) . The combined organic layers were dried over anhydrous Na2SO4and concentrated in vacuo. The residue was purified by silica gel column chromatography eluted with PE/EtOAc (v/v) 9/1 to give a colorless oily product (4.43 g, 92.3) .[1798]MS (ESI, pos. ion) m/z: 233.2 [M+1]+.
Reference: [1] Patent: WO2016/615, 2016, A1, . Location in patent: Paragraph 00725
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