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Chemical Structure| 886498-99-3 Chemical Structure| 886498-99-3

Structure of 886498-99-3

Chemical Structure| 886498-99-3

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Product Details of [ 886498-99-3 ]

CAS No. :886498-99-3
Formula : C8H6F4O2
M.W : 210.13
SMILES Code : OCC1=CC=C(OC(F)(F)F)C(F)=C1
MDL No. :MFCD06660204

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Application In Synthesis of [ 886498-99-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 886498-99-3 ]

[ 886498-99-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 473917-15-6 ]
  • [ 886498-99-3 ]
YieldReaction ConditionsOperation in experiment
With sodium tetrahydroborate; In methanol; at 0 - 20℃; for 3h; (3-Fluoro-4-(trifluoromethoxy)phenyl)methanol. NaBH4 (1.36 g, 36.0 mmol) is added in portions to a sol. of 3- fluoro-4-(thfluoromethoxy)benzaldehyde (5.00 g, 24.0 mmol) in MeOH (80 mL) at 0 C. The mixture is stirred for 3 h while warming up to rt. Water is added carefully and the solvents are partially removed under reduced pressure. The residue is extracted with CH2CI2 (2x). The combined org. layers are dried over MgS04, filtered, and the solvents are removed under reduced pressure to yield the crude title product. LC-MS: tR = 0.77 min., conditions 3.
 

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