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[ CAS No. 886528-42-3 ] {[proInfo.proName]}

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Chemical Structure| 886528-42-3
Chemical Structure| 886528-42-3
Structure of 886528-42-3 * Storage: {[proInfo.prStorage]}
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Product Details of [ 886528-42-3 ]

CAS No. :886528-42-3 MDL No. :MFCD22418017
Formula : C14H18BF3O3 Boiling Point : -
Linear Structure Formula :- InChI Key :FMASTXATFLPSON-UHFFFAOYSA-N
M.W : 302.10 Pubchem ID :60082933
Synonyms :

Safety of [ 886528-42-3 ]

Signal Word:Warning Class:
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 UN#:
Hazard Statements:H302-H315-H319 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 886528-42-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 886528-42-3 ]

[ 886528-42-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 106854-77-7 ]
  • [ 73183-34-3 ]
  • [ 886528-42-3 ]
YieldReaction ConditionsOperation in experiment
85% With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); potassium acetate; In N,N-dimethyl-formamide; at 100℃; for 2h; To the compound (5.0 g, 20 mmol) obtained in step 413 1, 341 bis(pinacolato)diboron (7.4 g, 29mmol), 342 potassium acetate (5.7 g, 58 mmol) and 244 1,1?-bis(diphenylphosphino)ferrocenedichloropalladium(II) (1.4 g, 1.9 mmol) was added 107 N,N-dimethylformamide (100 mL) andthe mixture was stirred at 100 C. for 2 hr. The insoluble material was filtered off, 5 diethyl ether wasadded to the filtrate and the mixture was washed with water, dried over sodium sulfate, and the desiccant wasfiltered off. The solvent was evaporated and the obtained residue was purified by silica gel columnchromatography (petroleum ether) to give the 415 title compound ( 5.0 g , 17 mmol, 85%). MS (ESI) m/z 303 (M+H)+ 1H NMR (400 MHz, CDCl3) delta 7.82-7.79 (m, 2H), 6.97-6.93 (m, 2H), 4.43-4.35 (m, 2H), 1.36 (s, 12H).
47% With potassium acetate;(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 20 - 110℃;Inert atmosphere; To a stirred solution of 0 (0.5 g, 1.96 mmol) in 1,4-dioxane (50 mL) was added bis(pinacolato)diboron (0.54 g, 2.15 mmol) followed by potassium acetate (KOAc; 0.576 g, 5.88 mmol) at RT under inert atmosphere. After purging with N2 for 10 min, Pd(dppf)2Cl2 (72 mg, 0.09 mmol) was added to the reaction mixture under N2 atmosphere. The mixture was gradually heated to 110 C. and stirred for 2 h. After complete consumption of the starting material (by TLC), the volatiles were evaporated under reduced pressure; the obtained residue was dissolved in H2O (100 mL) and extracted with EtOAc (3*50 mL). The combined organic extracts were washed with H2O (50 mL) and brine (50 mL), dried over anhydrous Na2SO4 and concentrated in vacuo. The crude material was purified by silica gel column chromatography (eluting with 3-4% EtOAc/hexane) to afford I-F (0.28 g, 0.92 mmol, 47%) as a yellow syrup. 1H NMR (200 MHz, CDCl3): delta 7.78 (d, J=8.5 Hz, 2H), 6.93 (d, J=8.5 Hz, 2H), 4.37 (q, J=8.2 Hz, 2H), 1.36 (s, 12H).
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