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[ CAS No. 886779-69-7 ]

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Chemical Structure| 886779-69-7
Chemical Structure| 886779-69-7
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CAS No. :886779-69-7 MDL No. :MFCD08686626
Formula : C10H17F3N2O2 Boiling Point : 263.4±35.0°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :254.25 g/mol Pubchem ID :66599850
Synonyms :

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Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 886779-69-7 ]

  • Upstream synthesis route of [ 886779-69-7 ]
  • Downstream synthetic route of [ 886779-69-7 ]

[ 886779-69-7 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 131922-05-9 ]
  • [ 886779-69-7 ]
YieldReaction ConditionsOperation in experiment
90% at 20℃; for 3 h; To a solution of 2-(trifluoromethyl)piperazine (135 mg, 0.876 mmol) in DCM (6 ml) were added di-tert-butyl dicarbonate (0.224 ml, 0.963 mmol) and the resulting mixture was stirred at RT for 3 h, then concentrated and the residue was purified via silica gel chromatography (0 - 100 percent EtOAc in hexanes) to give tert-butyl 3 -(trifluoromethyl)piperazine-l -carboxylate (200 mg, 0.787 mmol, 90 percent yield) as a pale yellow solid. MS (ES+) C10H17F3N2O2 requires: 254, found: 155 [M+H]+- Boc group.
Reference: [1] Patent: WO2018/136887, 2018, A1, . Location in patent: Page/Page column 122
[2] Patent: WO2014/175621, 2014, A1, . Location in patent: Paragraph 662; 663; 664
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