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[ CAS No. 887399-47-5 ]

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Chemical Structure| 887399-47-5
Chemical Structure| 887399-47-5
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Product Details of [ 887399-47-5 ]

CAS No. :887399-47-5 MDL No. :MFCD31652120
Formula : C15H20ClF3N2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :352.78 g/mol Pubchem ID :66674451
Synonyms :

Safety of [ 887399-47-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 887399-47-5 ]

  • Downstream synthetic route of [ 887399-47-5 ]

[ 887399-47-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 887399-27-1 ]
  • [ 887399-47-5 ]
  • [ 887399-46-4 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20.0℃; To a solution of 6-(3-amino-phenylamino)-1,3-dihydro-indol-2-one (120 mg, 0.50 mmol, prepared as described in Example 1) and 4-(4-ethyl-piperazin-1-ylmethyl)-3-trifluoromethyl-benzoic acid hydrochloride (213 mg, 0.60mmol) in DMF (5 mL) is added N,N-diisopropylethylamine (437 muL, 2.5 mmol) followed by addition of HATU (191 mg, 0.50 mmol). The mixture is stirred at ambient temperature overnight. The mixture is dilute with EtOAc and washed with 10% Na2S2O3 aqueous solution and brine. The organic layer is separated, dried over MgSO4, and concentrated. The crude is purified by column chromatography (CH2Cl2/CH3OH=9:1) to give the desired compound. LC-MS: 538.2 (MH+).
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