[ CAS No. 88938-12-9 ]

Name: 88938-12-9|4,4'-(9H-Fluorene-9,9-diyl)bis(2-methylphenol)|98%
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Product Details of [ 88938-12-9 ]

CAS No. :	88938-12-9	MDL No. :	MFCD04038046
Formula :	C₂₇H₂₂O₂	Boiling Point :	533.40°C at 760 mmHg
Linear Structure Formula :	-	InChI Key :	-
M.W :	378.46 g/mol	Pubchem ID :	-
Synonyms :

Safety of [ 88938-12-9 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 88938-12-9 ]

Downstream synthetic route of [ 88938-12-9 ]

[ 88938-12-9 ] Synthesis Path-Downstream 1~15

1
[ 88938-12-9 ]
[ 943722-36-9 ]
[ 383-29-9 ]
polymer; monomer(s): bis(4-fluorophenyl)sulfone; 9,9-bis(4-hydroxy-3-methylphenyl)fluorene; propyl-carbamic acid 3,5,3\,,5\-tetramethyl-4\-propylcarbamoyloxy-biphenyl-4-yl ester [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2007,vol. 129,p. 3879 - 3887

2
[ 88938-12-9 ]
[ 383-29-9 ]
polymer; monomer(s): bis(4-fluorophenyl)sulfone; 9,9-bis(4-hydroxy-3-methylphenyl)fluorene [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2007,vol. 129,p. 3879 - 3887

3
[ 75-21-8 ]
[ 88938-12-9 ]
[ 156326-34-0 ]
C₃₃H₃₄O₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 99.2 %Chromat. 2: 0.8 %Chromat.	In 2-methoxy-ethanol at 100℃; for 10h;	12; 13 EXAMPLE 12 [0155] Reaction of adding EO to biscresol fluorene (BCF) as a multivalent phenol was carried out in the similar manner as in Example 1 except for the following. Specifically, into an autoclave, charged was 100 g of BCF, with addition of 200 g of ethyleneglycol monomethyl ether (δ=11.4), and 10.0 g of anion exchange resin A (Cl-type dried material), and the autoclave was sealably closed. Next, 29.1 g of EO was added to the mixture, and the mixture was aged in the autoclave at 100° C. for 10 hours. After the aging, the anion exchange resin A was separated from the reaction solution by filtration. [0156] The composition of the reaction solution was analyzed according to LC. The LC analyzing conditions were the same as in Example 3 except for the use of 0.1% by mass of the mixed solution of phosphoric acid and methanol (35:65 in volume ratio). A result of LC analysis on the composition of the reaction solution reveals that all the raw material BCF was converted (inversion rate is 100%), and the content of BCF-2EO adduct was 96.3%, and the content of BCF-3EO adduct was 3.4%, respectively. No BCF-LEO adduct was detected. BCF-1EO adduct is ether obtained by reaction of either one of two hydroxyl groups in BCF with one EO molecule. BCF-2EO adduct is ether obtained by reaction of both of two hydroxyl groups in BCF with two EO molecules. BCF-3EO adduct is ether in which one of two hydroxyl groups in BCF is reacted with one EO molecule, whereas the other one of the two hydroxyl groups in BCF is reacted with two EO molecules. [0157] EXAMPLE 13; Crystallization-purification of the reaction solution obtained in Example 12 was carried out. Into a separable flask equipped with a stirrer, a cooling device, and a thermometer, charged was a solution for crystallization, which is the reaction solution obtained in Example 12. The flask was heated in an oil bath at 95° C. Next, the solution was cooled from 95° C. to 40° C. at a cooling rate of 5° C./hour while stirring the solution at 200 rpm. As a result of stirring, the solution was turned into a slurry having fluidity in its entirety. Then, the slurry was retained at 40° C. for 1 hour. Thus, crystallization was terminated. The slurry was subjected to filtration, and the filtrate was washed with 40 g of ethylene glycol monomethyl ether at normal temperature. Then, the filtrate was depressurized and dried at 60° C., thereby yielding the purified product. As is the case of Example 12, a result of LC analysis on the composition of the purified product reveals that the content of BCF-2EO adduct was 99.2%, the content of BCF-3EO adduct was 0.8%, respectively, and the yield of BCF-2EO adduct was 60%.

Reference： [1]Current Patent Assignee: NIPPON SHOKUBAI CO LTD - US2004/181099, 2004, A1 Location in patent: Page 14-15

4
fluorenone [ No CAS ]
[ 95-48-7 ]
[ 88938-12-9 ]

Yield	Reaction Conditions	Operation in experiment
89%	With hydrogenchloride; 3-mercaptopropionic acid In water at 25 - 35℃; for 17h;	1 Example 1 In a 2 L glass vessel equipped with a stirrer, a cooler and a thermometer were charged fluorenone (75g) having a purity of 99% by weight, o-cresol (270g), β-mercaptopropionic acid (8.5g), and 36% by weight of hydrochloric acid aqueous solution (27g). The mixture was subjected to a reaction with stirring under an atmosphere of an inert gas at 25°C for 6 hours, followed by at 35°C for 11 hours. The analysis of the reaction product by HPLC showed that the remaining amount of fluorenone was not more than 0.1% by weight. After toluene (300g) and water (80g) were added to the resultant reaction solution, an aqueous solution containing sodium hydroxide (32% by weight) was added to the mixture for neutralization to approximately pH 7, then the resulting water layer was removed. The organic layer was heated to 80°C, and washed with water (80g) three times. After collecting toluene (300g) by distillation under a reduced pressure, a mixture (500 ml) containing toluene and acetone at a mixing ratio (weight ratio) [toluene/acetone] of 1/4 was added to the organic layer, and stirred at 70°C for one hour. Then, the resultant mixture was cooled to 10°C for crystallization to give an object product, 9,9-bis(4-hydroxy-3-methylphenyl)fluorene (140g, yield 89%). The purity of thus obtained fluorene derivative was 99.6% by weight. Moreover, the b value was 1.3 (colorless and transparency). The fluorene derivative can be therefore used as a raw material of polymer without further crystallization operation.
76%	With hydrogenchloride; 3-mercaptopropionic acid at 50℃; for 4h;	1 Comparative Example 1 In a 2 L glass vessel equipped with a stirrer, a cooler, a thermometer and a tube for supplying hydrogen chloride gas were charged fluorenone (75g) having a purity of 99% by weight, o-cresol (160g), and ?-mercaptopropionic acid (2g), and fluorenone was completely dissolved in the mixture with stirring and heating at 50C under an atmosphere of an inert gas. A hydrogen chloride gas was passed through the mixture at a feed rate of 200 ml/minute, and initiated the reaction. The reaction was continued for 4 hours with maintaining the reaction temperature of 50C. After complication of the reaction, a nitrogen gas was passed through the reaction mixture at a feed rate of 5 L/minute for 30 minutes to drive out the remaining hydrogen chloride gas in the vessel. After toluene (300g) and water (80g) were added to thus obtained reaction solution, an aqueous solution containing sodium hydroxide of 32% by weight was added to the mixture for neutralization to approximately pH 7, then the water layer was removed. The organic layer was heated to 80C, and washed with water (80g) three times. After collecting toluene (300g) by distillation under a reduced pressure, a mixture (500 ml) containing toluene and acetone at a mixing ratio [toluene/acetone] of 1/4 (weight ratio) was added to the organic layer, and stirred at 70C for one hour. Thereafter, the resultant mixture was cooled to 10C for crystallization to give an object product, 9,9-bis(4-hydroxy-3-methylphenyl)fluorene (120g, yield 76%). The purity of the resulting fluorene derivative was 95.2% by weight. Moreover, the b value was 12.5 (light yellow), and it was necessary to operate crystallization further 3 times under the same conditions in order to obtain the fluorene derivative having the b value of not more than 3 which was required to use as a raw material for a polymer.

Reference： [1]Current Patent Assignee: OSAKA GAS CO LTD - EP1471045, 2004, A1 Location in patent: Page 6-7
[2]Current Patent Assignee: OSAKA GAS CO LTD - EP1471045, 2004, A1 Location in patent: Page 7

5
[ 486-25-9 ]
[ 95-48-7 ]
[ 107-96-0 ]
[ 88938-12-9 ]

Yield	Reaction Conditions	Operation in experiment
	In water; toluene	E.5 Preparation of 9,9-Bis(4-hydroxy-3-methylphenyl)fluorene EXAMPLE E-5 Preparation of 9,9-Bis(4-hydroxy-3-methylphenyl)fluorene The following procedure is employed to prepare 9,9-bis(4-hydroxy-3-methylphenyl)fluorene, which may be represented by the following structure: STR4 To a stirred mixture of fluorenone (18 g; 0.1 mole), o-cresol (57.5 g, 0.53 mole), and sulfated zirconium oxyhydroxide catalyst E-1 (15 g) is added 0.3 ml of 3-mercaptopropionic acid. The mixture is stirred and heated at 85° C. for 3 hr. Analysis by gas chromatography gives the results set forth in Table I. It is seen that the sulfated zirconium oxyhydroxide catalyst is capable of catalyzing the condensation of fluorene with cresol, the cresol conversion being greater than 95 percent and the selectivity for 9,9-bis(4-hydroxy-3-methylphenyl)fluorene being 98 mole percent. The reaction mixture is cooled, and 100 ml each of toluene and water are added. The catalyst is filtered off. The filtrate is concentrated on a rotary evaporator to remove an o-cresol/water azeotropic mixture. Water, 100 ml, is added to the residue, and the o-cresol/water azeotrope is distilled off a second time. The addition of water and distillation are repeated two more times, and then the residue is dissolved in 100 ml of boiling toluene. On cooling, 9,9-bis(4-hydroxy-3-methylphenyl)fluorene crystallizes as white crystals which are separated by filtration and washed with hexane (29.9 g; mp 214°-217° C.; 79 mole percent isolated yield). Concentration of the filtrate provided a second crop of product (3.0 g) for a total isolated yield of 87 mole percent; GC purity is greater than 99 percent.

Reference： [1]Current Patent Assignee: DOW INC - US5304688, 1994, A

6
[ 486-25-9 ]
[ 95-48-7 ]
[ 88938-12-9 ]

Yield	Reaction Conditions	Operation in experiment
92%	With 3-mercaptopropionic acid In chlorobenzene at 140℃; for 6h;	1; 2; 9; 11.2 Example 9: 288g of 9-fluorenone, 600g of o-methylphenol, 200g of activated clay catalyst, 16g of 3-mercaptopropionic acid, 2500g of chlorobenzene were sequentially added to a 5KL three port equipped with a stirrer, thermometer and water separator (with condenser) In the flask, the mixture was stirred, heated to reflux (140 ° C) and separated by water, and reacted for 6 hours. After the reaction, the mixture was filtered while hot, and the residue was recovered at 120 ° C for the next reaction. The filtrate was cooled to 10 ° C and then incubated for 1 hour. A crude gray product was obtained, which was recovered and used in the next reaction of the product; the crude product was recrystallized from toluene-methanol to give a white solid, 9,9-bis(3-methyl-4-hydroxyphenyl)indole product, 556.4 g. The yield was 92%, and the melting point was 218.6 to 220.2 ° C, and the HPLC purity was 99.5%.
84.3%	With hydrogenchloride In water; toluene at 50℃; for 2h;	3 Example 3 A reaction was carried out by feeding 23 g of fluorenone, 1.3 g of dodecyl mercaptan, and 161.0 g of 2-methyl phenol into a 500 ml glass reactor vessel equipped with a stirrer, a condenser and a thermometer, (b) dropping 13.0 g of 35% hydrochloric acid to a mixture, and (c) stirring the mixture at 50° C. for 2 hours. The amount of remaining fluorenone was determined by HPLC, and found to be 0.1% or less. To an obtained reaction mixture liquid, 18.5 g of 29% sodium hydroxide aqueous solution was added, and thereafter 94.0 g of 2-methyl phenol was distilled away from an organic phase by concentration under reduced pressure. To an obtained concentrated liquid, 161 g of toluene and 23 g of water were added, and the mixture liquid was stirred at 80° C. Thereafter, an aqueous phase was separated and removed, and a target substance partitioned in the organic phase was recovered. The organic phase was further washed twice with 23 g of water, and cooled to 10° C. Then, precipitated crystals were subjected to filtration and drying to obtain 37.9 g of 9,9-bis(4-hydroxy-3-methylphenyl)fluorene (yield: 84.3%, LC purity: 99.3%). Obtained 9,9-bis(4-hydroxy-3-methylphenyl)fluorene was dissolved by heat at 230° C. for 2 hours. The 9,9-bis(4-hydroxy-3-methylphenyl)fluorene thus dissolved had a hue of 1 in Gardner. The total amount of toluene used in the production was 4.2 parts by weight relative to 1 part by weight of the 9,9-bis(4-hydroxy-3-methylphenyl)fluorene.
39 g	With hydrogenchloride; 1-dodecylthiol at 40 - 45℃; for 4h; Inert atmosphere;	1 Synthesis Example 1 Synthesis of A- 19 gand 1.0 g of water were put into 1 L of a three-neck flask including a thermometer, a stirring blade, a dropping funnel, and a reflux cooling pipe, nitrogen substitution was performed in a system, and then, hydrogen chloride gas was blown into the system until the system was saturated at 40° C. A mixed liquid of 35.5 g of o-cresol and 23.7 g of 9-fluorenone was gradually dropped while maintaining the temperature in the system to be 40° C. to 45° C. Afier the dropping ended, a reaction was further performed at 45° C. for 4 hours. After the reaction ended, 28 g of an aqueous solution of sodium hydroxide of 12% was added, neutralization was performed, 50 g of acetone was added, and crystals were dissolved. After that, cooling was performed to a room temperature, and the educed crystals were filtered.10257] The obtained crude crystals were dissolved in alarge amount of acetone and were recrystallized, and thus, atarget compound A-i 9 was obtained (39 g, white crystals).

85.6 %Chromat.

With methanol; sulfuric acid; 1-dodecylthiol In toluene at 50℃; for 2.5h; Inert atmosphere;

27 Example 27 In a full-jacket type 1 L, separable flask equipped with a thermometer, a stirrer, and 100 mL, 26 g (0.8 mol) of methanol was added under a nitrogen atmosphere, and then 58.5 g (0.5 mol) of 90% by weight sulfuric acid was slowly added thereto to provide a solution in which monomethyl sulfate was produced. Thereafter, 60 g of toluene, 197.0 g (1.8 mol) of ortho-cresol, and 5.5 g (0.03 mol) of dodecanethiol were added thereto, followed by setting the temperature in the separable flask to 50° C. Subsequently, 136 g (0.8 mol) of fluorenone was placed therein, and slowly fed dropwise to the separable flask for 30 minutes. Thereafter, the reaction was allowed to proceed at 50° C. for 2 hours. After completion of the reaction, 100.0 g of ethyl acetate and 100.0 g of demineralized water were fed, and the resulting mixture was mixed. Thereafter, the mixture was left to stand, and the aqueous phase in the lower layer, was extracted. Thereafter, saturated sodium hydrogen carbonate solution was added to the obtained organic phase to allow neutralization, followed by confirming that the pH of the aqueous phase in the lower layer, became not less than 9. After extraction of the aqueous phase in the lower layer, demineralized water was added to the obtained organic phase, and the resulting mixture was stirred for 10 minutes. Thereafter, the mixture was left to stand, and the aqueous phase was extracted. Part of the obtained organic phase was removed and subjected to measurement by high-performance liquid chromatography. As a result, production of 9,9-bis(4-hydroxy-3-methylphenyl) fluorene was found. Its production rate was 85.6% by area.

Reference： [1]Current Patent Assignee: WUHAN POLYTECHNIC UNIVERSITY; HUANGHUA XINNUO LIXING FINE CHEMICAL STOCK CO LTD; WUHAN FOLUOYI TECHNOLOGY CO LTD - CN108863728, 2018, A Location in patent: Paragraph 0030-0033; 0046; 0047; 0050; 0053; 0054
[2]Current Patent Assignee: SUMITOMO CHEMICAL COMPANY LIMITED; Sumitomo Chemical (w/o Dongwoo Fine-Chem) - US2012/29244, 2012, A1 Location in patent: Page/Page column 12
[3]Current Patent Assignee: FUJIFILM HOLDINGS CORP. - US2016/376463, 2016, A1 Location in patent: Paragraph 0256; 0257
[4]Current Patent Assignee: Mitsubishi Chemical Corp (in: MCHC Group); MITSUBISHI CHEMICAL HOLDINGS CORPORATION - US2020/190004, 2020, A1 Location in patent: Paragraph 0283

7
[ 88938-12-9 ]
C₃₇H₃₄O₈ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: water; ethanol / 2 h / 80 °C 2: 6 h / 80 °C

Reference： [1]Current Patent Assignee: FUJIFILM HOLDINGS CORP. - US2016/280621, 2016, A1

8
[ 88938-12-9 ]
C₃₁H₃₀O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: water; ethanol / 2 h / 80 °C 2: 6 h / 80 °C 3: potassium carbonate / 2 h / 60 °C

Reference： [1]Current Patent Assignee: FUJIFILM HOLDINGS CORP. - US2016/280621, 2016, A1

9
[ 88938-12-9 ]
[ 50-00-0 ]
[ 124-40-3 ]
C₃₃H₃₆N₂O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
95%	In ethanol; water at 80℃; for 2h;	C-1A Synthesis of Compound (C-1A) A mixture of 18.8 g of 9,9-bis(4-hydroxy-3-methylphenyl)fluorene (manufactured by Wako Pure Chemical Industries, Ltd.), 19.8 g of a 50% aqueous dimethylamine solution, 6.6 g of paraformaldehyde, and 10 mL of ethanol was stirred at 80° C. for 2 hours. After ethanol was distilled off, 50 mL of ethyl acetate and 50 mL of water were added to the mixture to carry out liquid separation. The organic layer was washed twice with 50 mL of water. The resulting organic layer was dried over magnesium sulfate, dried and then filtered. The solvent in the filtrate was distilled off to give 23.4 g (yield: 95%) of (C-1A) as a crude product.

Reference： [1]Current Patent Assignee: FUJIFILM HOLDINGS CORP. - US2016/280621, 2016, A1 Location in patent: Paragraph 0424

10
[ 88938-12-9 ]
[ 1204-28-0 ]
C₄₅H₂₆O₁₀ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
96.2%	With pyridine; In toluene; acetonitrile; at 4 - 84℃; for 5.5h;Inert atmosphere;	A thermometer, a dropping funnel, a stirrer, a 1L four-necked flask equipped with a reflux condenser was charged with 130.20 g (344.0 mmol) of 9,9-bis(4-hydroxy-3-methylphenyl)fluorenone, 166.60 g (791.2 mmol) of trimellitic anhydride chloride (hereinafter sometimes referred to as TAC) 260.28 g of acetonitrile was charged, under a nitrogen atmosphere, after stirring, cooled to 4 C. After cooling, Further, 62.63 g (791.8 mmol) of pyridine was added dropwise at 4 C. to 10 C. over 2 hours. After completion of the dropwise addition, 260.28 g of toluene was charged, after that, The temperature was raised to reflux, refluxed (internal temperature 82 to 84 C.) And the mixture was stirred for 3.5 hours. After completion of stirring, The reaction solution was measured by HPLC, The residual ratio of the raw material 9,9-bis (4-hydroxy-3-methylphenyl) fluorenone was 0.0% The formation rate of the monoester (ester formed by the reaction of 1 mole of 9,9-bis (4-hydroxy-3-methylphenyl) fluorenone and 1 mole of trimellitic anhydride) was 0.3% The formation rate of the objective tetracarboxylic acid dianhydride represented by the above formula (5) was 97.8%. After the reaction, the reaction solution was cooled to 26 C and the precipitated crystals were separated by filtration at the same temperature. After filtration, crystals was further washed four times with 260.28 g of acetonitrile, and the obtained crystals were dried under vacuum at 90 C. and dried to obtain 240.38 g of a tetracarboxylic acid dianhydride crystal represented by the above formula (5) (yield 96.2%).

Reference： [1]Patent: JP2017/203005,2017,A .Location in patent: Paragraph 0040-0042; 0046-0055

11
[ 88938-12-9 ]
[ 822-48-0 ]
9,9-bis[4-(3-methyl-3-oxetanyl)methoxy-3-methylphenyl]fluorene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
95.7%	With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 60 - 100℃; for 13h;	2 Comparative Example 2 BCF (28.4 g, 75 mmol) was dissolved in DMF (168 g), then potassium carbonate (26.3 g, 190 mmol), KI (1.28 g, 7.7 mmol) was added and stirred at 60 ° C. To this solution, 3-chloromethyl-3-methyloxetane (24.87 g, 206 mmol) was added dropwise at 60 ° C. After completion of the dropwise addition, the mixture was heated to 80 ° C. and reacted for 5 hours, and further heated to 100 ° C. And allowed to react for 8 hours. After completion of the reaction, 525 mL of water was added, and extraction with 112 g of ethyl acetate was performed three times. Furthermore, washing with 100 g of water was carried out six times, and the obtained organic phase (ethyl acetate phase) was concentrated under reduced pressure to obtain 39.2 g (yield: 95.7%) of a compound in the form of pale orange crystals.

Reference： [1]Current Patent Assignee: OSAKA GAS CO LTD - JP2018/108985, 2018, A Location in patent: Paragraph 0114

12
[ 96-49-1 ]
[ 88938-12-9 ]
[ 156326-34-0 ]

Yield	Reaction Conditions	Operation in experiment
89.5%	With potassium carbonate In toluene at 115℃; for 16h;	1 Example 1 Agitator, nitrogen injection pipe, and a temperature gauge glass reactor equipped with a cooling tube, 9,9-bis (4-hydroxy-3-methylphenyl) fluorene 60g, ethylenecarbonate 32.0g, potassium carbonate 3.0g and toluene 30g is applied, by heating and stirring time 16 115 °C 9,9-bis (4-hydroxy-3-methylphenyl) fluorene contg. bis hydroxyethyl ether 82.4% of a reaction product is obtained. The reaction product of toluene 420g, 12.0% by weight aqueous sodium hydroxide 120g, tetrabutylammonium bromide 0.9g is added, with stirring preipitated 85 °C 1 placed after separating an organic solvent phase, 5.3% by weight of the organic solvent, adding hydrochloric 120g, 15 minutes at 85 °C placed preipitated stirring, separated by an organic solvent phase, to remove a water layer containing hydrochloric acid. Water is added to the organic solvent phase 90g, 15 minutes at 85 °C placed preipitated stirring, organic solvent phase is separated from the liquid portion. The same operation is repeated twice more 2. Thereafter, the organic solvent phase after 300g concd. than toluene, cooled to 25 °C to precipitate crystals. Furthermore, the deposited crystals is filtered, dried, 9,9-bis (4 - (2-ethoxy) - 3-methylphenyl) fluorene crystal 66.2g (yield 89.5%) is obtained. The obtained white crystals, 96.1% purity.

Reference： [1]Current Patent Assignee: Sumitomo Chemical (w/o Dongwoo Fine-Chem); SUMITOMO CHEMICAL COMPANY LIMITED - JP2016/138071, 2016, A Location in patent: Paragraph 0066; 0075

13
[ 88938-12-9 ]
[ 814-68-6 ]
C₃₃H₂₆O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With 4-methoxy-phenol; triethylamine In toluene at 25℃; for 2h;	4 Comparative Example 4: Production Example of Acrylate Compound Represented by Formula (7) In a 500 ml glass reaction vessel equipped with a stirrer, a cooler and a thermometer, 60.00 g (0.16 mol) of 9,9-bis(4-hydroxy-3-methylphenyl)fluorene, 0.22 g (0.0017 mol) of p-methoxyphenol, 35.29 g (0.35 mol) of triethylamine and toluene were added, and stirred at 25° C. Thereafter, 30.13 g (0.33 mol) of acrylic acid chloride was added, and the mixture was reacted for 2 hours while the above temperature was maintained. After the reaction, the reaction liquid was subjected to HPLC analysis, and the result showed that an acrylate compound represented by the formula (7) was produced in an amount of 89.6%. The obtained reaction liquid was neutralized by adding 5% sodium bicarbonate aqueous solution thereto, then washed with water twice, and concentrated under reduced pressure to obtain 61.7 g of an acrylate compound represented by the formula (7) (yield: 80.0% and HPLC purity: 93.0%). Table 3 shows the measurement results of the refractive index, Abbe number, melting point or glass transition temperature (Tg), and solubility in the diluent for the obtained acrylate compound represented by the formula (7).

Reference： [1]Current Patent Assignee: Sumitomo Chemical (w/o Dongwoo Fine-Chem); SUMITOMO CHEMICAL COMPANY LIMITED - US2019/55180, 2019, A1 Location in patent: Paragraph 0339; 0340; 0341; 0342; 0343

14
[ 88938-12-9 ]
[ 15852-73-0 ]
9,9-bis[4-(3-(hydroxymethyl)phenyloxy)-3-methylphenyl]fluorene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
31.1%	With 1,3-dimethyl-2-imidazolidinone; 8-quinolinol; potassium carbonate; copper(l) chloride at 140℃; for 72h; Inert atmosphere;	1 Example 1 In a 4-necked 2 L flask, under nitrogen stream, BCF167 g (0.44 mol),198 g (1.06 mol) of m-bromobenzyl alcohol,N,N′-dimethyl-2-imidazolidinone (DMI) 334 g, potassium carbonate 91.5 g (0.66 mol), copper(I) chloride 3.5 g (35.4 mmol)And 8-quinolinol 5.1 g(35.1 mmol) was charged,The reaction was carried out at 140°C for 72 hours.After cooling the reaction solution to room temperature,600 g of toluene,The liquid was extracted and separated with 300 g of ion-exchanged water. The organic layer was washed twice with 150 g of 1N hydrochloric acid to decompose insoluble matter (decomposed at pH 2-3), and washed twice with 100 g of ion-exchanged water.After that, neutralization treatment is performed twice with 150 g of a 2% by mass aqueous sodium hydroxide solution,The pH of the aqueous layer was adjusted to 7 by washing with 200 g of ion-exchanged water 10 times.By concentrating the organic layer under reduced pressure,329 g of a brown viscous liquid was obtained. The brown viscous liquid was dissolved at 50° C. with 450 g of toluene, seed crystals were added (added) and recrystallized overnight in a freezer, and the precipitate was washed with 50 g of toluene three times and collected.The same recrystallization operation is performed 5 times to collect the precipitate, and the precipitate is dried under reduced pressure at 60 to 80° C. to obtain the target compound represented by the following formula (2-1):9,9-bis[4-(3-(hydroxymethyl)phenyloxy)-3-methylphenyl]fluorene81.0 g (31.1% yield, 96.4 area% HPLC purity) were obtained in the form of light brown crystals.The measurement results of 1H-NMR are shown below.

Reference： [1]Current Patent Assignee: OSAKA GAS CO LTD - JP2020/83889, 2020, A Location in patent: Paragraph 0164-0166

15
[ 88938-12-9 ]
[ 15852-73-0 ]
9,9-bis[4-(3-(acryloyloxymethyl)phenyloxy)-3-methylphenyl]fluorene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 1,3-dimethyl-2-imidazolidinone; copper(l) chloride; potassium carbonate; 8-quinolinol / 72 h / 140 °C / Inert atmosphere 2: 2-methoxy-phenol; p-toluenesulfonic acid monohydrate / toluene / 4 h / 60 - 115 °C / Dean-Stark; Inert atmosphere

Reference： [1]Current Patent Assignee: OSAKA GAS CO LTD - JP2020/83889, 2020, A

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 88938-12-9 ]

Quality Control of [ 88938-12-9 ]

Related Doc. of [ 88938-12-9 ]

Product Details of [ 88938-12-9 ]

Safety of [ 88938-12-9 ]

Application In Synthesis of [ 88938-12-9 ]

[ 88938-12-9 ] Synthesis Path-Downstream 1~15

Related Functional Groups of [ 88938-12-9 ]

Aryls

Aryls

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 88938-12-9 ]