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[ CAS No. 889676-35-1 ] {[proInfo.proName]}

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Chemical Structure| 889676-35-1
Chemical Structure| 889676-35-1
Structure of 889676-35-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 889676-35-1 ]

CAS No. :889676-35-1 MDL No. :MFCD08436023
Formula : C9H11BrN2O3S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 307.16 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 889676-35-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 889676-35-1 ]

[ 889676-35-1 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 1198437-75-0 ]
  • [ 889676-35-1 ]
  • [ 1309778-68-4 ]
YieldReaction ConditionsOperation in experiment
In N,N-dimethyl-formamide at 120℃; for 0.25h; Microwave irradiation; 19 2-Methyl-N-[1 -(phenylsulfonyl)-6-(trimethylstannanyl)-1 H-indazol-4-yl]-1 ,3-thiazole-4- carboxamide (50 mg) was placed in a microwave vial with Pd(PPh3)4 (10 mg) and 4-[(5- bromo-3-pyridinyl)sulfonyl]morpholine (30 mg). DMF (2 ml) was added and the reaction was heated in the microwave for 15 min at 120 °C. To the residue was added I PA (2 ml) and 2M NaOH (aq) (1 ml) and the mixture stirred at RT for 3 h. The solvent was blown off under nitrogen and the residue purified by MDAP (method A) to give the title compound as a white solid, 17 mg.LCMS (method B) Rt = 0.86 min, MH+ = 485.
  • 2
  • [ 1240286-83-2 ]
  • [ 889676-35-1 ]
  • [ 1240285-85-1 ]
YieldReaction ConditionsOperation in experiment
Stage #1: tert-butyl (4-chloro-2-ethynylphenoxy)acetate; 4-(5-bromopyridin-3-ylsulfonyl)morpholine With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; triethylamine In tetrahydrofuran at 60℃; for 16h; Inert atmosphere; Stage #2: With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃;
YieldReaction ConditionsOperation in experiment
With triethylamine In tetrahydrofuran; dichloromethane at 0 - 20℃; for 1h; 38.1 Step 1. 5-Bromo-N,N-dimethylpyridine-3-sulfonamide General procedure: To a solution of triethylamine (0.5 mL, 4 mmol) in dichloromethane (5 mL) was added 2.0 M dimethylamine in tetrahydrofuran (0.58 mL, 1.2 mmol). The resultant solution was cooled to 0° C. and 5-bromopyridine-3-sulfonyl chloride [Combi-Blocks, ST-7824] (200 mg, 0.8 mmol) in dichloromethane (1mL) was added dropwise. After stirring at 0° C. to room temperature over 1 h, the reaction mixture was concentrated via rotovap. The residue was purified by FCC to afford the title compound (0.12 g, 60%) LCMS for C7H10BrN2O2S (M+H)+: calculated m/z=265.0, 267.0; found 264.9, 266.9.
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