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Chemical Structure| 889939-14-4 Chemical Structure| 889939-14-4

Structure of 889939-14-4

Chemical Structure| 889939-14-4

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Product Details of [ 889939-14-4 ]

CAS No. :889939-14-4
Formula : C14H15FN4
M.W : 258.29
SMILES Code : FC1=CC=C(C2=NC=CN=C2N3CCNCC3)C=C1
MDL No. :MFCD26096706

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Application In Synthesis of [ 889939-14-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 889939-14-4 ]

[ 889939-14-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 436096-96-7 ]
  • [ 889939-14-4 ]
  • [ 1082066-15-6 ]
YieldReaction ConditionsOperation in experiment
82% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃; for 18.0h; Preparation 68: [3'-(4-Fluorophenyl)-2,3,5,6-tetrahydro-[l,2']bipyrazinyl-4-yl]-(l- isopropyl-lH-pyrazol-4-yl)-methanone Dissolve l-isopropyl-lH-pyrazole-4-carboxylic acid (0.120 g, 0.780 mmol) inDCM (5 mL). Add etaOBt (0.088 g, 0.650 mmol) followed by l-(3-dimethyl- aminopropyl)-3-ethylcarbodiimide hydrochloride (0.125 g, 0.650 mmol). Add 3'-(4- fluorophenyl)-3,4,5,6-tetrahydro-2eta-[l,2']bipyrazinyl (0.168 g, 0.650 mmol) and stir at room temperature for 18 hr. Add DCM and water and separate layers. Extract aqueous layer 3 times with DCM, dry (magnesium sulfate), filter, concentrate and purify (silica gel chromatography, eluting with 25:75 to 100:0 ethylacetate/hexanes), to give the title preparation (211 mg, 82%). MS (ES): m/z = 395 [M+H]+.
 

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