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Chemical Structure| 890315-73-8 Chemical Structure| 890315-73-8

Structure of 890315-73-8

Chemical Structure| 890315-73-8

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Product Details of [ 890315-73-8 ]

CAS No. :890315-73-8
Formula : C11H14BrNO2
M.W : 272.14
SMILES Code : O=C(OC(C)(C)C)C1=CC=C(Br)C=C1N
MDL No. :MFCD12805971

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Application In Synthesis of [ 890315-73-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 890315-73-8 ]

[ 890315-73-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 890315-72-7 ]
  • [ 890315-73-8 ]
YieldReaction ConditionsOperation in experiment
Iron powder 3.0g were added to a mixed solution methanol 28mL and acetic acid 28mL of <strong>[890315-72-7]tert-butyl 4-bromo-2-nitrobenzoate</strong> 5.5g, it was heated and refluxed for 1 hour. After the reaction mixture was cooled to room temperature, saturated sodium hydrogen carbonate aqueous solution and ethyl acetate were added to it, and insoluble matter was filtrated. The organic layer was separated and collected, dried over anhydrous magnesium sulfate after sequential washing with saturated sodium hydrogen carbonate aqueous solution and saturated sodium chloride aqueous solution, the solvent was removed under reduced pressure to give tert-butyl 2-amino-4-bromobenzoate 4.3g of pale yellow oil. 1H-NMR-(DMSO-d6) delta value: 1.52(9H,s),6.65(1H,dd,J=8.5,2.0Hz),6.78(2H,s),6.98(1H,d ,J=2.0Hz),7.55(1H,d,J=8.5Hz).
  • 2
  • [ 890315-72-7 ]
  • [ 7439-89-6 ]
  • [ 890315-73-8 ]
YieldReaction ConditionsOperation in experiment
With sodium bicarbonate; acetic acid; In methanol; ethyl acetate; Referential Example 4 3.0 g of iron powder was added to a mixed solution of 28 mL of methanol and 28 mL of acetic acid containing 5.5 g of <strong>[890315-72-7]tert-butyl 4-bromo-2-nitrobenzoate</strong>, and the resulting mixture was heated to reflux for 1 hour. After the reaction mixture was cooled to room temperature, a saturated sodium hydrogen carbonate aqueous solution and ethyl acetate were added and insoluble were removed by filtration. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium hydrogen carbonate aqueous solution and a saturated sodium chloride aqueous solution sequentially, and the solvent was evaporated under reduced pressure to obtain 4.3 g of tert-butyl 2-amino-4-bromobenzoate as pale yellow oil. 1H-NMR (DMSO-d6) delta: 1.52 (9H, s), 6.65 (1H, dd, J = 8.5, 2.0 Hz), 6.78 (2H, s), 6.98 (1H, d, J = 2.0 Hz), 7.55 (1H, d, J = 8.5 Hz).
 

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