* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With Oxone®; tetrabutylammomium bromide In water; acetone at 20℃;
General procedure: A mixture of 2-(methylthio)pyrimidines (5 mmol), tetrabutylammonium bromide (0.16 g, 0.5 mmol, 10 molpercent) and acetone (20 mL) was stirred at room temperature. The Oxone (12.5 mmol, 2.5 equiv) in water (20 mL) was added slowly to the vigorously stirred solution. After 4–6 h, TLC indicated the consumption of the starting material. The products 5 were isolated by filtering through a Buechner funnel and washed with water, and then dried to give the solid product. Yields, melting points and spectroscopic data for selected 2-(methylsulfonyl)pyrimidines are listed as follows.
Reference：
[1] Synthetic Communications, 2018, vol. 48, # 6, p. 714 - 720
[2] Patent: US5599770, 1997, A,
[3] Patent: US5723412, 1998, A,
4-chloro-6-methoxy-2-(phenylmethoxy)pyrimidine[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
With benzyl alcohol; In toluene;
Synthesis Example 6 Synthesis of 4-chloro-6-methoxy-2-(phenylmethoxy)pyrimidine (Compound I-346) 4-Chloro-6-methoxy-2-(methylsulfonyl)pyrimidine (Compound III-29) (0.80 g, 0. 0036 mol) and benzyl alcohol (Compound II-64) (0.39 g, 0.0036 mol) were dissolved in toluene (10 ml), and then 60% sodium hydride (0.16 g, 0.0036*1.1 mol) was added while cooling with ice. After stirred for one night at room temperature, the reaction solution was poured into water and extracted with ethyl acetate. The organic phase was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and filtered, and thereafter, the solvent was distilled off to afford a crude product (0.92 g), which was then purified on silica gel column chromatography to obtain the compound (I-346) as an oily product. Yield: 0.5 g.
With potassium peroxymonosulphate; tetrabutylammomium bromide; In water; acetone; at 20.0℃;
General procedure: A mixture of 2-(methylthio)pyrimidines (5 mmol), tetrabutylammonium bromide (0.16 g, 0.5 mmol, 10 mol%) and acetone (20 mL) was stirred at room temperature. The Oxone (12.5 mmol, 2.5 equiv) in water (20 mL) was added slowly to the vigorously stirred solution. After 4-6 h, TLC indicated the consumption of the starting material. The products 5 were isolated by filtering through a Buechner funnel and washed with water, and then dried to give the solid product. Yields, melting points and spectroscopic data for selected 2-(methylsulfonyl)pyrimidines are listed as follows.
With dihydrogen peroxide; In acetic acid;
(2) Synthesis of Compound III-29 from the intermediate The compound (IV-29) (19.0 g, 0.100 mol) which was the intermediate obtained in the step (1) above, was dissolved in acetic acid (200 ml), then 31% aqueous hydrogen peroxide (25.2 g, 0.100*2.3 mol) was added, and the solution was heated to 100 C. while stirring. After stirred for 2 hours, the reaction solution was poured into water and extracted with ethyl acetate. The organic phase was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and filtered, and thereafter, the solvent was distilled off to obtain a crude product (20.0 g), which was then purified on silica gel column chromatography (Wakogel C300, 300 ml, ethyl acetate/hexane=400 ml/400 ml) to obtain the compound (III-29) as a white crystalline product from the fraction of 300 ml to 600 ml. Yield: 11.5 g. m.p. 68 to 74 C. 1 H-NMR (60 MHz, CDCl3, delta): 3.30(3H,s), 4.07(3H,s), 6.87 (1H,s).
With dihydrogen peroxide; In acetic acid;
(2) Synthesis of an immediately preceding intermediate, 4-chloro-6-methoxy-2-(methylsulfonyl)pyrimidine (Compound No. VIII-7) The intermediate obtained from the preceding section (1), the Compound No. VII-7 (19.0 g, 0.100 mol) was dissolved in acetic acid (200 ml), and aqueous 31% hydrogen peroxide (25.2 g, 0.100*2.3 mol) was added thereto, and the mixture was heated to 100 C. while stirring. After stirred for 2 hours, the reaction solution was poured into water and extracted with ethyl acetate. The organic phase was washed with aqueous saturated sodium chloride, dried over anhydrous sodium sulfate and concentrated, and thereafter the solvent was distilled off to obtain a crude product 20.0 g. The product was then purified on silica gel column chromatography (Wakogel C300, 300 ml, ethyl acetate/hexane=400 ml/400 ml) to obtain the Compound No.
With potassium carbonate; In N-methyl-acetamide; ice-water;
EXAMPLE 1 N-(2-Difluoromethoxy-6-methylphenyl)-1-(4-chloro-6-methoxypyrimidin-2-yl)-1H-1,2,4-triazole-3-sulphonamide 1.8 g (6 mmol) N-(2-Difluoromethoxy-6-methylphenyl)-1H-1,2,4-triazole-3-sulphonamide in 10 ml dimethylformamide was stirred with 1.68 g (12 mmol) potassium carbonate for 10 minutes at 50 C. It was then cooled to 10 C. and treated with 1.33 g (6 mmol) <strong>[89466-55-7]4-chloro-6-methoxy-2-methylsulphonylpyrimidine</strong> and the mixture stirred for 45 minutes at 10 C. It was then added to ice-water, acidified to pH 4 with sulphuric acid and the solid collected and purified by silica gel chromatography using a mixture of methylene chloride and methanol (95/5). Yield: 1.1 g=41% of theory. M.p.: 215-216 C.
With hydrogenchloride; In tetrahydrofuran; hexane; water;
EXAMPLE 2 Preparation of 2-anilino-4-chloro-6-methoxypyrimidine (Compound 1) 1.8 g of formanilide was dissolved in 50 ml of tetrahydrofuran, and 0.4 g of sodium hydride from which the oily matter had been removed before hand with n-hexane was slowly added to the resulting solution at 10 to 20 C. while cooling with ice water. To the suspension thus obtained was added 3.3 g of <strong>[89466-55-7]4-chloro-2-methanesulfonyl-6-methoxypyrimidine</strong>, and the mixture was stirred for 1 hour at room temperature. Then, 15 ml of 4N hydrochloric acid was added, and reaction was effected for 1 hour under reflux. The reaction liquid was poured in water, extracted with ether, and the ether layer was washed with water, dried over magnesium sulfate, and then the ether was stripped by concentration. The residual crystals were recrystallized from n-hexane, and 4.0 g of 2-anilino-4-chloro-6-methoxypyrimidine was obtained (yield 87%). Melting point: 101-103 C.
87%
With hydrogenchloride; In tetrahydrofuran; hexane; water;
EXAMPLE 2 Preparation of 2-anilino-4-chloro-6-methoxypyrimidine (Compound 1) 1.8 g of formanilide was dissolved in 50 ml of tetrahydrofuran, and 0.4 g of sodium hydride from which the oily matter had been removed beforehand with n-hexane was slowly added to the resulting solution at 10 to 20C while cooling with ice water. To the suspension thus obtained was added 3.3 g of <strong>[89466-55-7]4-chloro-2-methanesulfonyl-6-methoxypyrimidine</strong>, and the mixture was stirred for 1 hour at room temperature. Then, 15 ml of 4N hydrochloric acid was added, and reaction was effected for 1 hour under reflux. The reaction liquid was poured in water, extracted with ether, and the ether layer was washed with water, dried over magnesium sulfate, and then the ether was stripped by concentration. The residual crystals were recrystallized from n-hexane, and 4.0 g of 2-anilino-4chloro-6-methoxypyrimidine was obtained (yield 87%). Melting point: 101-103C.
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