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[ CAS No. 89488-24-4 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 89488-24-4
Chemical Structure| 89488-24-4
Structure of 89488-24-4 * Storage: {[proInfo.prStorage]}
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Product Details of [ 89488-24-4 ]

CAS No. :89488-24-4 MDL No. :MFCD11052614
Formula : C6H6BBrO3 Boiling Point : -
Linear Structure Formula :- InChI Key :WILLYOUMVYALAT-UHFFFAOYSA-N
M.W : 216.83 Pubchem ID :21917370
Synonyms :

Safety of [ 89488-24-4 ]

Signal Word:Warning Class:
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 UN#:
Hazard Statements:H302-H315-H319 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 89488-24-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 89488-24-4 ]

[ 89488-24-4 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 608-33-3 ]
  • [ 89488-24-4 ]
  • 2
  • [ 121-43-7 ]
  • [ 608-33-3 ]
  • [ 89488-24-4 ]
YieldReaction ConditionsOperation in experiment
47% Compound a1-<strong>[608-33-3]2,6 dibromophenol</strong> (9.47 g, 37.6 mmol)Dissolved in tetrahydrofuran (140 mL),Add hexane solvent and 2.5M at -78 CAfter n-butyl lithium (18 mL, 45.1 mmol),Stir for 1 hour.Then slowly add trimethyl borate (13 mL, 56.4 mmol)After that, stir for 2 hours.Then add 2M hydrochloric acid to neutralize,The product was extracted with ethyl acetate and water.Recrystallization from dichloromethane and hexane gave compound b1 (4.10 g, 47%).Weighed compound b1 (5.82 g, 25.1 mmol),Compound c1 (7.13 g, 25.1 mmol),Tetrakistriphenylphosphine palladium (11g, 10mmol)And potassium carbonate (8.42 g, 60.9 mmol),The weighed reaction was dissolved in toluene (1 L) / EtOH (200 mL) /In the solvent of distilled water (200 mL),Heat at 90 C for 2 hours.Weighed compound d1 (12.50 g, 38 mmol),Add KOH and Cu powder,And heating at 200 C to carry out the reaction,Compound e1 was obtained.
47% Compound a1-<strong>[608-33-3]2,6 dibromophenol</strong> (9.47 g, 37.6 mmol) was dissolved in tetrahydrofuran (140 mL).After dropwise addition of a hexane solvent and 2.5 M n-butyllithium (18 mL, 45.1 mmol) at -78 C,Stir for 1 hour.Further, trimethyl borate (13 mL, 56.4 mmol) was slowly added dropwise, followed by stirring for 2 h.It was further neutralized by dropwise addition of 2M hydrochloric acid, and the product was extracted with ethyl acetate and water.Recrystallization from dichloromethane and hexane gave compound b1 (4.10 g, 47%).Weighed compound b1 (5.82 g, 25.1 mmol),Compound c1 (7.13 g, 25.1 mmol),Tetrakistriphenylphosphine palladium (11 g, 10 mmol) and potassium carbonate (8.42 g, 60.9 mmol),The weighed reactant was dissolved in a solvent of toluene (1 L) / EtOH (200 mL) / distilled water (200 mL), and heated at 90 C for 2 hours.Weighed compound d1 (12.50 g, 38 mmol),KOH and Cu powder were added, and the reaction was carried out by heating at 200 C to obtain a compound e1.
  • 3
  • [ 89488-24-4 ]
  • [ 408502-43-2 ]
  • C11H7Br2NO [ No CAS ]
YieldReaction ConditionsOperation in experiment
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; at 90℃; for 2h; Compound a1-2,6 dibromophenol (9.47 g, 37.6 mmol)Dissolved in tetrahydrofuran (140 mL),Add hexane solvent and 2.5M at -78 CAfter n-butyl lithium (18 mL, 45.1 mmol),Stir for 1 hour.Then slowly add trimethyl borate (13 mL, 56.4 mmol)After that, stir for 2 hours.Then add 2M hydrochloric acid to neutralize,The product was extracted with ethyl acetate and water.Recrystallization from dichloromethane and hexane gave compound b1 (4.10 g, 47%).Weighed compound b1 (5.82 g, 25.1 mmol),Compound c1 (7.13 g, 25.1 mmol),Tetrakistriphenylphosphine palladium (11g, 10mmol)And potassium carbonate (8.42 g, 60.9 mmol),The weighed reaction was dissolved in toluene (1 L) / EtOH (200 mL) /In the solvent of distilled water (200 mL),Heat at 90 C for 2 hours.Weighed compound d1 (12.50 g, 38 mmol),Add KOH and Cu powder,And heating at 200 C to carry out the reaction,Compound e1 was obtained.
  • 4
  • [ 89488-24-4 ]
  • [ 265981-13-3 ]
  • C11H7Br2NO [ No CAS ]
YieldReaction ConditionsOperation in experiment
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; at 90℃; for 2h; Compound a1-2,6 dibromophenol (9.47 g, 37.6 mmol) was dissolved in tetrahydrofuran (140 mL).After dropwise addition of a hexane solvent and 2.5 M n-butyllithium (18 mL, 45.1 mmol) at -78 C,Stir for 1 hour.Further, trimethyl borate (13 mL, 56.4 mmol) was slowly added dropwise, followed by stirring for 2 h.It was further neutralized by dropwise addition of 2M hydrochloric acid, and the product was extracted with ethyl acetate and water.Recrystallization from dichloromethane and hexane gave compound b1 (4.10 g, 47%).Weighed compound b1 (5.82 g, 25.1 mmol),Compound c1 (7.13 g, 25.1 mmol),Tetrakistriphenylphosphine palladium (11 g, 10 mmol) and potassium carbonate (8.42 g, 60.9 mmol),The weighed reactant was dissolved in a solvent of toluene (1 L) / EtOH (200 mL) / distilled water (200 mL), and heated at 90 C for 2 hours.Weighed compound d1 (12.50 g, 38 mmol),KOH and Cu powder were added, and the reaction was carried out by heating at 200 C to obtain a compound e1.
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