Alternatived Products of [ 89488-24-4 ]
Product Details of [ 89488-24-4 ]
CAS No. : | 89488-24-4 |
MDL No. : | MFCD11052614 |
Formula : |
C6H6BBrO3
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | WILLYOUMVYALAT-UHFFFAOYSA-N |
M.W : |
216.83
|
Pubchem ID : | 21917370 |
Synonyms : |
|
Application In Synthesis of [ 89488-24-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 89488-24-4 ]
- 1
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[ 608-33-3 ]
-
[ 89488-24-4 ]
- 2
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[ 121-43-7 ]
-
[ 608-33-3 ]
-
[ 89488-24-4 ]
Yield | Reaction Conditions | Operation in experiment |
47% |
|
Compound a1-<strong>[608-33-3]2,6 dibromophenol</strong> (9.47 g, 37.6 mmol)Dissolved in tetrahydrofuran (140 mL),Add hexane solvent and 2.5M at -78 CAfter n-butyl lithium (18 mL, 45.1 mmol),Stir for 1 hour.Then slowly add trimethyl borate (13 mL, 56.4 mmol)After that, stir for 2 hours.Then add 2M hydrochloric acid to neutralize,The product was extracted with ethyl acetate and water.Recrystallization from dichloromethane and hexane gave compound b1 (4.10 g, 47%).Weighed compound b1 (5.82 g, 25.1 mmol),Compound c1 (7.13 g, 25.1 mmol),Tetrakistriphenylphosphine palladium (11g, 10mmol)And potassium carbonate (8.42 g, 60.9 mmol),The weighed reaction was dissolved in toluene (1 L) / EtOH (200 mL) /In the solvent of distilled water (200 mL),Heat at 90 C for 2 hours.Weighed compound d1 (12.50 g, 38 mmol),Add KOH and Cu powder,And heating at 200 C to carry out the reaction,Compound e1 was obtained. |
47% |
|
Compound a1-<strong>[608-33-3]2,6 dibromophenol</strong> (9.47 g, 37.6 mmol) was dissolved in tetrahydrofuran (140 mL).After dropwise addition of a hexane solvent and 2.5 M n-butyllithium (18 mL, 45.1 mmol) at -78 C,Stir for 1 hour.Further, trimethyl borate (13 mL, 56.4 mmol) was slowly added dropwise, followed by stirring for 2 h.It was further neutralized by dropwise addition of 2M hydrochloric acid, and the product was extracted with ethyl acetate and water.Recrystallization from dichloromethane and hexane gave compound b1 (4.10 g, 47%).Weighed compound b1 (5.82 g, 25.1 mmol),Compound c1 (7.13 g, 25.1 mmol),Tetrakistriphenylphosphine palladium (11 g, 10 mmol) and potassium carbonate (8.42 g, 60.9 mmol),The weighed reactant was dissolved in a solvent of toluene (1 L) / EtOH (200 mL) / distilled water (200 mL), and heated at 90 C for 2 hours.Weighed compound d1 (12.50 g, 38 mmol),KOH and Cu powder were added, and the reaction was carried out by heating at 200 C to obtain a compound e1. |
- 3
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[ 89488-24-4 ]
-
[ 408502-43-2 ]
-
C11H7Br2NO
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; at 90℃; for 2h; |
Compound a1-2,6 dibromophenol (9.47 g, 37.6 mmol)Dissolved in tetrahydrofuran (140 mL),Add hexane solvent and 2.5M at -78 CAfter n-butyl lithium (18 mL, 45.1 mmol),Stir for 1 hour.Then slowly add trimethyl borate (13 mL, 56.4 mmol)After that, stir for 2 hours.Then add 2M hydrochloric acid to neutralize,The product was extracted with ethyl acetate and water.Recrystallization from dichloromethane and hexane gave compound b1 (4.10 g, 47%).Weighed compound b1 (5.82 g, 25.1 mmol),Compound c1 (7.13 g, 25.1 mmol),Tetrakistriphenylphosphine palladium (11g, 10mmol)And potassium carbonate (8.42 g, 60.9 mmol),The weighed reaction was dissolved in toluene (1 L) / EtOH (200 mL) /In the solvent of distilled water (200 mL),Heat at 90 C for 2 hours.Weighed compound d1 (12.50 g, 38 mmol),Add KOH and Cu powder,And heating at 200 C to carry out the reaction,Compound e1 was obtained. |
- 4
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[ 89488-24-4 ]
-
[ 265981-13-3 ]
-
C11H7Br2NO
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; at 90℃; for 2h; |
Compound a1-2,6 dibromophenol (9.47 g, 37.6 mmol) was dissolved in tetrahydrofuran (140 mL).After dropwise addition of a hexane solvent and 2.5 M n-butyllithium (18 mL, 45.1 mmol) at -78 C,Stir for 1 hour.Further, trimethyl borate (13 mL, 56.4 mmol) was slowly added dropwise, followed by stirring for 2 h.It was further neutralized by dropwise addition of 2M hydrochloric acid, and the product was extracted with ethyl acetate and water.Recrystallization from dichloromethane and hexane gave compound b1 (4.10 g, 47%).Weighed compound b1 (5.82 g, 25.1 mmol),Compound c1 (7.13 g, 25.1 mmol),Tetrakistriphenylphosphine palladium (11 g, 10 mmol) and potassium carbonate (8.42 g, 60.9 mmol),The weighed reactant was dissolved in a solvent of toluene (1 L) / EtOH (200 mL) / distilled water (200 mL), and heated at 90 C for 2 hours.Weighed compound d1 (12.50 g, 38 mmol),KOH and Cu powder were added, and the reaction was carried out by heating at 200 C to obtain a compound e1. |