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Chemical Structure| 89590-22-7 Chemical Structure| 89590-22-7

Structure of 89590-22-7

Chemical Structure| 89590-22-7

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Product Details of [ 89590-22-7 ]

CAS No. :89590-22-7
Formula : C7H5NO2
M.W : 135.12
SMILES Code : OC1=C2N=COC2=CC=C1
MDL No. :MFCD06795900
InChI Key :MGQPBXGHGXFKJW-UHFFFAOYSA-N
Pubchem ID :13720697

Safety of [ 89590-22-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 89590-22-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 89590-22-7 ]

[ 89590-22-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 89590-22-7 ]
  • [ 3177-20-6 ]
  • 4-(benzo[d]oxazol-4-yloxy)-2-chloropyrimidine-5-carboxylic acid [ No CAS ]
  • 2
  • [ 89590-22-7 ]
  • [ 3177-20-6 ]
  • 4-(benzooxazol-4-yloxy)-2-chloro-pyrimidine-5-carboxylic acid methyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
87.7% With potassium carbonate; In N,N-dimethyl-formamide; acetone; at -40℃; for 6h; Following the preparation protocol of Section5.1.2.1, the reaction mixture of <strong>[3177-20-6]methyl 2,4-dichloropyrimidine-5-carboxylate</strong> (8e) (228 mg, 1.10 mmol), K2CO3 (276 mg,2.0 mmol) and 4-hydroxyl benzo[d]oxazole (3) (135 mg, 1.0 mmol)in DMF (1 mL) and acetone (9 mL) was stirred at 40 C for 6 h togive compound 9g as a white solid (268 mg, 87.7percent); mp 131?133C; 1H NMR (400 MHz, DMSO d6) d (ppm) 9.13 (s, 1H), 8.76 (s, 1H),7.80 (d, J = 8.0 Hz, 1H), 7.56 (t, J = 8.0 Hz, 1H), 7.37 (d, J = 8.0 Hz,1H), 3.93 (s, 3H); HRMS (ESI): m/z, Calcd. for C13H9O4N3Cl[M+H]+: 306.0276, Found 306.0273
 

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