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CAS No. : | 897958-99-5 | MDL No. : | MFCD13177816 |
Formula : | C8H6INO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 259.04 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P280-P301+P312-P302+P352-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In ethanol; toluene;Reflux; Inert atmosphere; | General procedure: Reaction of thiophene-2-boronic acid and 5-iodoisoindolin- 1-one according to general procedure C gave a crude product which was purified by flash column chromatography on silica gel (5% MeOH/CH2C12 as eluant) to give the title compound as a beige solid (60%), m.p. (CH2C12) 25 1-253C. ?H NMR[400 MHz, (CD3)2S0] 6 8.55 (br s, I H), 7.82 (br s, 1 H), 7.73 (dd, J = 7.9, 1.5 Hz, I H),7.68 (d, J 7.9 Hz, 1 H), 7.49 (d, J 3.9 Hz, I H), 7.31 (d, J 3.9 Hz, I H), 4.41 (s, 2 H).LRMS (APCI1) calcd for C,2H9BrNOS 294, 296 (MW), found 294, 296.Anal. (C12H8BrNOS) C, H, N. |