[ CAS No. 89943-34-0 ]

Name: 89943-34-0|4,6-Dimethoxypyridin-3-amine|97%
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Quality Control of [ 89943-34-0 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 89943-34-0 ]

SDS

Alternatived Products of [ 89943-34-0 ]

Product Details of [ 89943-34-0 ]

CAS No. :	89943-34-0	MDL No. :	MFCD09027594
Formula :	C₇H₁₀N₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	N/A
M.W :	154.17 g/mol	Pubchem ID :	53407822
Synonyms :

Calculated chemistry of of [ 89943-34-0 ]

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.29
Num. rotatable bonds :	2
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	41.63
TPSA :	57.37 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.92 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.7
Log Po/w (XLOGP3) :	0.45
Log Po/w (WLOGP) :	0.69
Log Po/w (MLOGP) :	-0.3
Log Po/w (SILICOS-IT) :	0.6
Consensus Log Po/w :	0.63

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.35
Solubility :	6.87 mg/ml ; 0.0446 mol/l
Class :	Very soluble
Log S (Ali) :	-1.22
Solubility :	9.23 mg/ml ; 0.0599 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.91
Solubility :	1.91 mg/ml ; 0.0124 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.01

Safety of [ 89943-34-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 89943-34-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 89943-34-0 ]

[ 89943-34-0 ] Synthesis Path-Downstream 1~13

1
[ 1187344-41-7 ]
[ 89943-34-0 ]
[ 1258492-33-9 ]

Yield	Reaction Conditions	Operation in experiment
3.7%	With caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene;palladium diacetate; In 1,4-dioxane; at 160.0℃; for 1.5h;Microwave irradiation;	A mixture of N-(2-(2,5-dichloropyrimidin-4-ylamino)-5-methoxyphenyl) methanesulfonamide (100 mg, 0.27 mmol), <strong>[89943-34-0]4,6-dimethoxypyridin-3-amine</strong> (75 mg, 0.33 mmol), palladium acetate (1 mg, 0.005 mmol), Xantphos (5 mg, 0.009 mmol) and cesium carbonate (360 mg, 1.1 mmol) in 1,4-dioxane (2 mL) was stirred at 1600C in the microwave for 90 min then diluted with water (5 mL) and extracted with ethyl acetate (5 mL). The organic layer was washed with brine (5 mL), dried (MgSO4) and concentrated in vacuo then was purified by preparative HPLC to afford the title compound (5 mg, 3.7%). 1H NMR (d6- DMSO) delta 8.35 (br s, IH), 8.06 (s, IH), 8.00 (d, IH), 7.61 (d, IH), 6.90 (d, IH), 6.69 (d, IH), 6.42 (s, IH), 3.81 (s, 3H), 3.75 (d, 6H), 2.91 (s, 3H); LCMS method B, (ES+) 481, RT = 7.25 min.

Reference： [1]Patent: WO2010/142766,2010,A2 .Location in patent: Page/Page column 42-43

2
[ 89943-34-0 ]
[ 1416324-68-9 ]
[ 1419610-69-7 ]

Yield	Reaction Conditions	Operation in experiment
64.6%	In isopropyl alcohol;Reflux;	1-(((1 S,3S)-3-(((4,6-Dimethoxypyridin-3-yl)amino)methyl)-3-hvdroxy-1- methylcvclohexaneyl)methyl)-1 H-benzordlimidazole-6-carbonitrileA mixture of 1-(((3S,5S)-5-methyl-1-oxaspiro[2.5]octan-5-yl)methyl)-1 H- benzo[d]imidazole-6-carbonitrile (100 mg, 0.355 mmol) and <strong>[89943-34-0]4,6-bis(methyloxy)-3-pyridinamine</strong> (1 10 mg, 0.71 1 mmol) in isopropanol (10 mL) was heated to reflux overnight. The reaction mixture was cooled to RT, and solvent was removed. The residue was redissolved in DCM and hexane was added. The solvent was removed, and the residue was purified via silica gel chromatography (ISCO, 40 g Silica, 40 mL/min, 0%-10% MeOH/CH2CI2). Fractions with product were collected and concentrated to afford 1-(((1 S,3S)-3-(((4,6-dimethoxypyridin-3- yl)amino)methyl)-3-hydroxy-1-methylcyclohexaneyl)methyl)-1 H-benzo[d]imidazole-6-carbonitrile (100 mg, 64.6% yield). MS (m/z) 436 (M+H+).

Reference： [1]Patent: WO2013/12500,2013,A1 .Location in patent: Page/Page column 88-89

3
[ 89943-34-0 ]
[ 1416324-68-9 ]
[ 1419608-70-0 ]

Reference： [1]Patent: WO2013/12500,2013,A1

4
[ 607373-84-2 ]
[ 89943-34-0 ]

Yield	Reaction Conditions	Operation in experiment
99%	With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; under 1500.15 Torr; for 7.0h;	To a QianCap glass reactor (1850 mL) equipped with magnetic stirrer was added C-7B2 (40 g, 217 mmol) followed by THF (500 mL). Next, 10% palladium on carbon (1.5 g) was added in one portion and the reactor was connected to the source of the hydrogen. Hydrogen pressure was set at 2 bar and reaction was well stirred for 7 h under continuous flow of hydrogen. After that time, UPLCMS analysis showed complete conversion of starting material. The reaction mixture was filtered through the Cellite pad and the filtrate was concentrated in vacuo. As a result, amine C-7B was obtained as a brown solid (33g, 99% yield).

Reference： [1]Patent: EP3511334,2019,A1 .Location in patent: Paragraph 0090-0091

5
[ 4487-56-3 ]
[ 89943-34-0 ]

Reference： [1]Patent: EP3511334,2019,A1

6
[ 89943-34-0 ]
6-chloro-3-(3-methyl-2-oxobutylidene)-1H-indol-2-one [ No CAS ]
N-(5-chloro-2-fluorophenyl)prop-2-ynamide [ No CAS ]
N-(5-chloro-2-fluorophenyl)-4-(6-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl)-1-(4,6-dimethoxypyridin-3-yl)-5-(propan-2-yl)-1H-pyrrole-3-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With acetic acid; at 85.0℃; for 16.0h;Sealed tube;	To a 100 mL flask equipped with magnetic stirring bar, compounds C-4A (7.79 g, 30 mmol, 1 eq), C-7B (4.68 g, 30 mmol, 1 eq) and C-6B (6 g, 30 mmol, 1 eq) were added followed by AcOH (60 mL), and the flask was tightly closed with plastic stopper. The mixture was heated up to 85 C (temperature of the heating bath) and stirred at this temperature for 16 h. After that time UPLCMS analysis showed almost full consumption of starting materials (which equals to 40 % of a product peak area). Reaction mixture was cooled to around 15 C and abundant red solid precipitate was separated by filtration from the reaction mixture. The filtrate was evaporated to dryness. The residue was preadsorbed onto silicagel and purified using flash chromatography (10 % to 60 % of AcOEt in n-hexane). After removing of the solvents product C-8.C9 was obtained as a light red solid (5.58 g, 31.5 % yield) with 93 % of purity according to UPLCMS analysis.

Reference： [1]Patent: EP3511334,2019,A1 .Location in patent: Paragraph 0172-0173

7
[ 89943-34-0 ]
6-chloro-3-(3-methyl-2-oxobutylidene)-1H-indol-2-one [ No CAS ]
N-(3,4-difluorophenyl)prop-2-ynamide [ No CAS ]
4-(6-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl)-N-(3,4-difluorophenyl)-1-(4,6-dimethoxypyridin-3-yl)-5-(propan-2-yl)-1H-pyrrole-3-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With acetic acid; at 85.0℃; for 16.0h;Sealed tube;	To a 500 mL flask equipped with magnetic stirring bar, compounds C-4A (8.1 g, 32.4 mmol, 1 eq), C-7B (5 g, 32.4 mmol, 1 eq) and C-6E (5.9 g, 32.4 mmol, 1 eq) were added followed by AcOH (80 mL), and the flask was tightly closed with plastic stopper. The mixture was heated up to 85 C (temperature of the heating bath) and stirred at this temperature for 16 h. After this time UPLCMS analysis showed almost full consumption of starting materials (which equals to 55 % of a product peak area). Reaction mixture was cooled to room temperature and AcOH was evaporated to dryness. The residue was preadsorbed onto silicagel and purified using flash chromatography (30 % to 60 % of AcOEt in n-hexane). After removing of solvents product C-8.C8 was obtained as a light red solid (8 g, 44 % yield) with 87 % of purity according to UPLCMS analysis.

Reference： [1]Patent: EP3511334,2019,A1 .Location in patent: Paragraph 0164-0165

8
[ 89943-34-0 ]
(3S)-6-chloro-2'-(3,4-difluorophenyl)-5'-(4,6-dimethoxypyridin-3-yl)-6'-(propan-2-yl)-1,2,3',5'-tetrahydro-2'H-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,3'-dione [ No CAS ]

Reference： [1]Patent: EP3511334,2019,A1

9
[ 89943-34-0 ]
6-chloro-2'-(3,4-difluorophenyl)-5'-(4,6-dimethoxypyridin-3-yl)-6'-(propan-2-yl)-1,2,3',5'-tetrahydro-2'H-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,3'-dione [ No CAS ]

Reference： [1]Patent: EP3511334,2019,A1

10
[ 89943-34-0 ]
4-(6-chloro-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-N-(3,4-difluorophenyl)-1-(4,6-dimethoxypyridin-3-yl)-5-(propan-2-yl)-1H-pyrrole-3-carboxamide [ No CAS ]

Reference： [1]Patent: EP3511334,2019,A1

11
[ 89943-34-0 ]
(3S)-6-chloro-2'-(5-chloro-2-fluorophenyl)-5'-(4,6-dimethoxypyridin-3-yl)-6'-(propan-2-yl)-1,2,3',5'-tetrahydro-2'H-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,3'-dione [ No CAS ]

Reference： [1]Patent: EP3511334,2019,A1

12
[ 89943-34-0 ]
6-chloro-2'-(5-chloro-2-fluorophenyl)-5'-(4.6-dimethoxypyridin-3-yl)-6'-(propan-2-yl)-1,2,3',5'-tetrahydro-2'H-spiro[indole-3,1'-pyrrolo[3.4-c]pyrrole]-2.3'-dione [ No CAS ]

Reference： [1]Patent: EP3511334,2019,A1

13
[ 89943-34-0 ]
N-(5-chloro-2-fluorophenyl)-4-(6-chloro-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-1-(4,6-dimethoxypyridin-3-yl)-5-(propan-2-yl)-1H-pyrrole-3-carboxamide [ No CAS ]

Reference： [1]Patent: EP3511334,2019,A1

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Ghs Precautionary Statements

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P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
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P230	Keep wetted
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P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
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P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
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P270	Do not eat, drink or smoke when using this product.
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P272	Contaminated work clothing should not be allowed out of the workplace.
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P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
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P285	In case of inadequate ventilation wear respiratory protection.
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Code	Phrase
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P314	Get medical advice/attention if you feel unwell.
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P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
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P342	If experiencing respiratory symptoms:
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P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 89943-34-0 ]

Quality Control of [ 89943-34-0 ]

Related Doc. of [ 89943-34-0 ]

Product Details of [ 89943-34-0 ]

Calculated chemistry of of [ 89943-34-0 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 89943-34-0 ]

Application In Synthesis of [ 89943-34-0 ]

[ 89943-34-0 ] Synthesis Path-Downstream 1~13

Related Functional Groups of [ 89943-34-0 ]

Amines

Ethers

Related Parent Nucleus of [ 89943-34-0 ]

Pyridines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 89943-34-0 ]

Related Parent Nucleus of
[ 89943-34-0 ]