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Chemical Structure| 9004-32-4 Chemical Structure| 9004-32-4
Chemical Structure| 9004-32-4

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Carboxymethylcellulose Sodium Salt is a cellulose derivative with carboxymethyl groups, can be used as thickener, emulsifier and binder in food and pharmaceutical industry.

Synonyms: CMC-Na(Viscosity 800-1200mpa.s)

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Product Citations

Product Citations

Samaha, Mahmoud M ; El-Desoky, Manal M ; Hisham, Fatma A ;

Abstract: Asthma is a long-term disease that causes airways swelling and inflammation and in turn airway narrowing. AdipoRon is an orally active synthetic small molecule that acts as a selective agonist at the adiponectin receptor 1 and 2. The aim of the current study is to delineate the protective effect and the potential underlying mechanism of adipoRon in airway inflammation induced by ovalbumin (OVA) in comparison with dexamethasone. Adult male Swiss Albino mice were sensitized to OVA on days 0 and 7, then challenged with OVA on days 14, 15 and 16. AdipoRon was administered orally for 6 days starting from the 11th day till the 16th and 1 h prior to OVA in the challenge days. Obtained results from asthmatic control group showed a significant decrease in serum adiponectin concentration, an increase in inflammatory cell counts in the bronchoalveolar lavage fluid (BALF), CD68 protein expression, inflammatory cytokine concentration and oxidative stress as well. Administration of adipoRon enhanced antioxidant mechanisms limiting oxidative stress by significantly increasing reduced glutathione (GSH) pulmonary content, decreasing serum lactate dehydrogenase (LDH) together with malondialdehyde (MDA) significant reduction in lung tissue. In addition, it modulated the levels of serum immunoglobulin E (IgE), pro-inflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-4, IL-13, nuclear factor kappa B (NF-κB) and the anti-inflammatory one IL-10 improving lung inflammation as revealed by histopathological evaluation. Furthermore, lung tissue expression of nuclear factor erythroid 2-related factor (Nrf2) and 5′ AMP-activated protein kinase (AMPK) were significantly increased adipoRon. Notably, results of adipoRon received group were comparable to those of dexamethasone group. In conclusion, our study demonstrates that adipoRon can positively modulate adiponectin expression with activation of AMPK pathway and subsequent improvement in inflammatory and oxidative signaling.

Keywords: Airway inflammation ; AdipoRon ; Adiponectin ; Nrf2 ; NF-κB ; AMPK

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Product Details of Carboxymethyl cellulose, sodium salt

CAS No. :9004-32-4
Formula : C8H15NaO8
M.W : 262.19
SMILES Code : NONE
Synonyms :
CMC-Na(Viscosity 800-1200mpa.s)
MDL No. :MFCD00081472

Safety of Carboxymethyl cellulose, sodium salt

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338
 

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