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Chemical Structure| 90204-94-7 Chemical Structure| 90204-94-7

Structure of 90204-94-7

Chemical Structure| 90204-94-7

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Product Details of [ 90204-94-7 ]

CAS No. :90204-94-7
Formula : C8H15NO2
M.W : 157.21
SMILES Code : O=C(C1CCN(CC)CC1)O
MDL No. :MFCD09055179

Safety of [ 90204-94-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Application In Synthesis of [ 90204-94-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 90204-94-7 ]

[ 90204-94-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 90204-94-7 ]
  • [ 851983-85-2 ]
  • [(3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl]-1-ethylpiperidine-4-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
78% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃; for 8h; To the reaction flask, 1-ethylpiperidine-4-carboxylic acid (0.71 g, 4.5 mmol), (3beta)-17-(1H-benzimidazol-1-yl)androsta-5,16-diene was successively added. 3-Alcohol (1a, 1.16 g, 3.0 mmol), 4-dimethylaminopyridine (DMAP) (0.11 g,0.9 mmol) 1-Ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI) (1.73 g, 9.0 mmol) and methylene chloride (15 mL) were reacted at room temperature for 8 hours. The system was added with 300 mL of dichloromethane, the organic layer was washed with water (500 mL×5), the organic phase was dried over anhydrous magnesium sulfate, filtered, and the filtrate was concentrated under reduced pressure to give a white solid [(3S,8R,9S,10R,13S, 14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopentadiene [a] Fen-3-yl]-1-ethylpiperidine-4-carboxylate (Compound 2) (1.25 g, yield 78percent).
 

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