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Chemical Structure| 904369-20-6 Chemical Structure| 904369-20-6

Structure of 904369-20-6

Chemical Structure| 904369-20-6

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Product Details of [ 904369-20-6 ]

CAS No. :904369-20-6
Formula : C10H6BrNO
M.W : 236.07
SMILES Code : O=CC1=NC2=CC(Br)=CC=C2C=C1
MDL No. :MFCD06824224

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Application In Synthesis of [ 904369-20-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 904369-20-6 ]

[ 904369-20-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 904369-20-6 ]
  • [ 103291-07-2 ]
  • (7-bromoquinolin-2-yl) (4-fluoro-3-methoxyphenyl)methanol [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: A mixture of arylbromide (1.0 eq), magnesium turnings (1.1 eq) and a catalytic amount of iodine in anhydrous THF was stirred for 2h at 60C under argon. A solution of the appropriate aldehyde in anhydrous THF was added and the reaction mixture was stirred at 80C. The end of the reaction was monitored by TLC. The mixture was quenched with brine and extracted with ethyl acetate. The combined organic layers were dried over magnesium sulfate, filtered and evaporated to dryness under reduced pressure. The crude product was purified by column chromatography.
 

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