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Chemical Structure| 906095-57-6 Chemical Structure| 906095-57-6

Structure of 906095-57-6

Chemical Structure| 906095-57-6

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Product Details of [ 906095-57-6 ]

CAS No. :906095-57-6
Formula : C9H10INO3
M.W : 307.09
SMILES Code : O=C(OC)C1=CC(I)=CC(OC)=C1N

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Application In Synthesis of [ 906095-57-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 906095-57-6 ]

[ 906095-57-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5121-34-6 ]
  • [ 906095-57-6 ]
YieldReaction ConditionsOperation in experiment
74% With iodine; silver sulfate; In ethanol; at 20℃; for 3h; Step A:; To a solution of <strong>[5121-34-6]methyl 2-amino-3-methoxybenzoate</strong> (2.00 g, 11.0 mmol) in ethanol (25 mL) was added silver sulfate (3.61 g, 11.6 mmol). To the above mixture was added iodine (2.94 g, 11.6 mmol). The resulting mixture was stirred at room temperature for 3 h. The reaction mixture was diluted with methylene chloride and water. The aqueous layer was separated and extracted with methylene chloride (2×100 mL). The combined organic layers were washed with a saturated solution of sodium hydrogen sulfite (2×100 mL), brine, dried over Na2SO4, filtered and concentrated to afford a dark brown solid. The crude material was purified by column chromatography (silica gel, 95:5 hexanes/ethyl acetate) to afford the desired product (2.49 g, 74%) as an off-white solid: 1H NMR (300 MHz, CDCl3) delta 7.60 (d, J=2.1 Hz, 1H), 6.90 (d, J=2.1 Hz, 1H), 6.03 (br s, 2H), 3.86 (s, 6H); MS (ESI+) m/z 308 (M+H).
 

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