Structure of 5121-34-6
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CAS No. : | 5121-34-6 |
Formula : | C9H11NO3 |
M.W : | 181.19 |
SMILES Code : | COC(=O)C1=C(N)C(OC)=CC=C1 |
MDL No. : | MFCD11113109 |
Boiling Point : | No data available |
InChI Key : | YJEZEMGLLFLMDF-UHFFFAOYSA-N |
Pubchem ID : | 602320 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Num. heavy atoms | 13 |
Num. arom. heavy atoms | 6 |
Fraction Csp3 | 0.22 |
Num. rotatable bonds | 3 |
Num. H-bond acceptors | 3.0 |
Num. H-bond donors | 1.0 |
Molar Refractivity | 48.62 |
TPSA ? Topological Polar Surface Area: Calculated from |
61.55 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
2.11 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
1.91 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
1.07 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
1.06 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
0.99 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
1.43 |
Log S (ESOL):? ESOL: Topological method implemented from |
-2.31 |
Solubility | 0.887 mg/ml ; 0.0049 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (Ali)? Ali: Topological method implemented from |
-2.83 |
Solubility | 0.271 mg/ml ; 0.00149 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-2.24 |
Solubility | 1.04 mg/ml ; 0.00573 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
No |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-6.05 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
1.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
1.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.59 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | With sulfuric acid; at 95℃; | (c) methyl 2-amino-3-methoxybenzoate To a solution of 2-amino-3-methoxybenzoic acid (34.5 g, 206 mmol) in MeOH (250 mL) was added concentrated H2SO4 (50 mL) slowly. The reaction mixture was heated at 95 C overnight. The reaction mixture was cooled to room temperature, and concentrated in vacuo. The residue was a beige slurry which was mixed with Et20 and poured slowly into a mixture of Et20 and cold aqueous saturated Na2C03 containing excess Na2C03. The Et20 layer was separated and aqueous layer was extracted with Et20 two more times. The combined Et20 extracts were washed with diluted NaOH (2x), brine and dried over Na2S04, filtered through a short silica plug and concentrated in vacuo to afford methyl 2-amino-3-methoxybenzoate (34.0 g, 91%) as a tan solid. LC-MS(ES) m/z = 182 [M+H]+. |
78.4% | With sulfuric acid; at 90℃; for 48h; | To a solution of 2-amino-3-methoxybenzoic acid (20 g, 119.64 mmol, 1 eq) in MeOH (250 mL) was added H2S04 (55.20 g, 551.56 mmol, 30 mL, 98% purity, 4.61 eq). The mixture was stirred at 90C for 48 h. The reaction mixture was concentrated under reduced pressure to remove MeOH. The residue was diluted with H20 (100 mL) and was added saturated aqueous NaHC03 until pH=8. The aqueous solution was extracted with EtOAc (50 mL x 3). The combined organic layers were washed with brine (75 mL x 2), dried over Na2S04, filtered and concentrated under reduced pressure to give methyl 2-amino-3-methoxybenzoate (17 g, 93.83 mmol, 78.4% yield) as brown oil. 1H NMR (CDCL, 400 MHz): d 7.48 (d, / = 7.2 Hz, 1H), 6.86 (d, / = 6.8 Hz, 1H), 6.58 (t, J = 8.0 Hz, 1H), 6.01 (br s, 2H), 3.88 (s, 6H) ppm. To a solution of methyl 2-amino-3-methoxybenzoate (16.5 g, 91.07 mmol, 1 eq) in DMF (200 mL) was added NCS (12.53 g, 93.80 mmol, 1.03 eq) at 25C. The resulting mixture was stirred and heated at 50C for 2 h. The reaction mixture was quenched by addition ice-water (500 mL) at 0C, and then extracted with EtOAc (100 mL x 3). The combined organic layers were washed with brine (300 mL x 3), dried over Na2S04, filtered and concentrated under reduced pressure to give methyl 2-amino-5-chloro-3- methoxybenzoate (19 g, 88.11 mmol, 96.8% yield) as brown oil, which was used into the next step without further purification. 'H NMR (CDCL, 400 MHz): d 7.46 (d, J = 2.0 Hz, 1H), 6.79 (d, J = 2.4 Hz, 1H), 6.01 (br s, 2H), 3.87 (s, 6H) ppm. To a solution of methyl 2-amino-5-chloro-3-methoxybenzoate (19 g, 88.11 mmol, 1 eq) in CH3CN (300 mL) was added CuBr2 (40 g, 179.09 mmol, 8.39 mL, 2.03 eq) resulting in a dark color. The mixture was stirred for 20 min at 25C, and t-BuONO (16.36 g, 158.60 mmol, 18.86 mL, 1.8 eq) was added dropwise over 10 min. The reaction mixture was stirred for additional 30 min, and then heated at 60C for 12 h. The reaction mixture was concentrated in vacuo, and water (300 mL) and EtOAc (100 mL) were added. The resulting mixture was stirred at 25C for 30 min. The organic phase became brown, and the aqueous was green with insoluble materials. The whole mixture was filtered through Celite and washed with EtOAc (100 mL x 3). The organic layer was separated, washed with brine (100 mL x 3), dried over Na2S04, filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (Si02, petroleum ether/ethyl acetate = 10/1 to 3/1) to give methyl 2-bromo-5-chloro-3-methoxybenzoate (16 g, 57.24 mmol, 65.0% yield) as a white solid. 1H NMR (CDCl , 400 MHz): d 7.28 (d, / = 2.4 Hz, 1H), 6.98 (d, J = 2.4 Hz, 1H), 3.94 (s, 3H), 3.93 (s, 3H) ppm. To a solution of methyl 2- bromo-5-chloro-3-methoxybenzoate (10 g, 35.78 mmol, 1 eq) in DCM (300 mL) was slowly added BBr3 (26.89 g, 107.33 mmol, 10.34 mL, 3 eq) at -78C under N2. To the reaction mixture was slowly added MeOH (100 mL), and the resulting mixture was stirred at 20C for 30 min. It was mixed with ice-water 500 mL at 0C, and the organic phase was separated. The aqueous was extracted with DCM (100 mL x 3). The combined organic layers were washed with brine (200 mL x 2), dried over Na2S04, filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (Si02, petroleum ether/ethyl acetate = 10/1 to 0/1) to give methyl 2-bromo-5-chloro-3 -hydroxy-benzoate (4 g, 15.07 mmol, 42.1% yield) as a yellow solid. 1H NMR (CDCl , 400 MHz): d 7.43 (d, / = 2.4 Hz, 1H), 7.20 (d, / = 2.4 Hz, 1H), 6.09 (s, 1H), 3.95 (s, 3H) ppm. To a solution of methyl 2-bromo-5-chloro-3- hydroxybenzoate (0.9 g, 3.39 mmol, 1 eq) in DMF (15 mL) and H20 (1.5 mL) were added sodium 2-chloro-2,2-difluoro-acetate (1.81 g, 11.86 mmol, 3.5 eq) and K2C03 (937.03 mg, 6.78 mmol, 2 eq) at 20C. The reaction was stirred under argon at l00C for 5 h. The reaction mixture was quenched by addition H20 (30 mL) at 20C, and then the aqueous was extracted with EtOAc (15 mL x 3). The combined organic layers were washed with brine (20 mL x 3), dried over Na2S04, filtered and concentrated under reduced pressure to give methyl 2-bromo-5-chloro-3-(difluoro methoxy)benzoate (750 mg, 2.38 mmol, 70.1% yield) as a yellow solid. 1H NMR (CDCl3, 400 MHz): d 7.60 (d, / = 2.4 Hz, 1H), 7.37 (d, / = 2.4 Hz, 1H), 6.56 (t, / = 72.8 Hz, 1H), 3.96 (s, 3H) ppm. A mixture of methyl 2-bromo-5-chloro-3-(difluoromethoxy)benzoate (0.7 g, 2.22 mmol, 1 eq), Pin2B2 (2.82 g, 11.09 mmol, 5 eq), KOAc (544.37 mg, 5.55 mmol, 2.5 eq), and Pd(PPh3)2Cl2 (155.73 mg, 221.87 umol, 0.1 eq) in l,4-dioxane (20 mL) was degassed and purged with N2 for 3 times, and then the mixture was stirred at l20C for 5 h under N2 atmosphere. The reaction was cooled and filtered. The filtrate was concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (Si02, petroleum ether/ethyl acetate = 30/1 to 5/1) to give methyl 5-chloro-3- (difluoromethoxy)-2-(4,4,5,5-tetram... |
With diazomethyl-trimethyl-silane; In hexane; benzene; | 2-amino-3-methoxybenzoic acid (22.8g, 137 mmol) was suspended in a mixture of benzene (300 mL) and methanol (120 mL) and a 2M solution of TMS- diazomethane in hexane was added dropwise until a yellow color remained and the evolution of nitrogen stopped (~90 mL). The solvent was evaporated to afford Intermediate 36 (25.2 g) as a brown solid which was used with out further purification. 1H NMR (400 MHz, CDCl3) delta ppm 3.87 (s, 6 H), 6.01 (bs, 2 H), 6.58 (t, J-7.91 Hz, 1 H), 6.85 (d, J=7.91 Hz, 1 H), 7.47 (d, J=7.91 Hz, 1 H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With N-Bromosuccinimide; In DMF (N,N-dimethyl-formamide); at 5℃; for 0.5h; | Step 3; The crude product (18.80 g) obtained in Step 2 was dissolved in dimethylformamide (200 ml) and N-bromosuccinimide (17.98 g, 0.10 mol) was added by portions at 5C. After the completion of the addition, the mixture was stirred at the same temperature for 30 min. The reaction mixture was poured into water (500 ml) and extracted twice with ethyl acetate (300 ml). The organic layer was washed with water (300 ml), saturated aqueous sodium hydrogen carbonate and saturated brine in this order, and dried over sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure, and the obtained residue was purified by silica gel chromatography (chloroform) to give the object product (25.11 g, yield 95%) as a yellow oil. ¹H NMR(CDC13 300MHz) (No.) ppm: 3.86 (6H, s) , 6.02 (2H, brs) , 6.90 (lH, s), 7.60 (lH, s) |
95% | With N-Bromosuccinimide; In DMF (N,N-dimethyl-formamide); at 5℃; for 0.5h; | The crude product (18.80 g) obtained in Step 2 was dissolved in dimethylformamide (200 ml), and N-bromosuccinimide (17.98 g, 0.10 mol) was added by portions at 5C. After completion of the addition, the mixture was stirred at the same temperature for 30 min. The reaction mixture was poured into water (500 ml) and extracted twice with ethyl acetate (300 ml). The organic layer was washed successively with water (300 ml), saturated aqueous sodium hydrogen carbonate and saturated brine, and dried over sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure and the obtained residue was purified by silica gel chromatography (chloroform) to give an object product (25.11 g, yield 95%) as a yellow oil.1H NMR (CDCl3 300MHz) (delta) ppm: 3.86 (6H, s), 6.02 (2H, brs), 6.90 (1H, s), 7.60 (1H, s) |
89% | With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20℃; for 2h; | Step A:; To a solution of 2-amino-3-methoxybenzoate (1.62 g, 8.97 mmol) in DMF (15 mL) was added N-bromosuccinimide (1.76 g, 9.87 mmol). The resulting mixture was stirred at room temperature for 2 h. The reaction mixture was diluted with ether and water. The aqueous layer was isolated and extracted with ether (2×100 mL). The combined organic layers were washed with water (2×100 mL), brine, dried over Na2SO4, filtered and concentrated to afford a brown solid. The crude material was purified by column chromatography (silica gel, 95:5 hexanes/ethyl acetate) to afford the desired product (2.08 g, 89%) as a light orange solid: 1H NMR (300 MHz, CDCl3) delta 7.60 (d, J=2.1 Hz, 1H), 6.90 (d, J=2.1 Hz, 1H), 6.03 (br s, 2H), 3.86 (s, 6H); MS (ESI+) m/z 259 (M+H). |
88.1% | With N-Bromosuccinimide; In N,N-dimethyl-formamide; for 1.25h;Cooling with ice; | [Step b] To a solution of compound 2 (86.7 g, 473 mmol) in N,N-dimethylformamide (430 mL) was added N-bromosuccinimide over 15 min under ice-cooling, and the mixture was stirred for 1 hr. To the reaction solution were added saturated aqueous sodium hydrogen carbonate solution (500 mL) and water (500 mL), and the mixture was extracted with ethyl acetate (1.0 L). The organic layer was washed with water and saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by silica gel chromatography, and suspended and washed in n-hexane (120 mL) to give compound 3 (108 g, 88.1 %). 1H-NMR (400 MHz, CDCl3)delta: 3.87(6H, s), 6.03(2H, brs), 6.90(1H, d, J=2.0Hz), 7.26(1H,s), 7.60(1H, d, J=2.4Hz). |
86% | With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0℃; for 0.5h; | To a solution of 15 <strong>[5121-34-6]methyl 2-amino-3-methoxybenzoate</strong> (22.4 g 123 mmol) in 7 DMF (250 mL) was added 17 N-bromosuccinimide (21.9 g, 123 mmol) portionwise at 0 C. The mixture was stirred at 0 C. for 0.5 h. To the mixture was added 9 water and extracted with EtOAc (500 mL×2). The combined organic layer was dried over MgSO4, filtered, and concentrated in vacuo. The residue was purified by silica gel column chromatography to provide the 18 title compound (27.5 g, 86%) as a white solid. 1H NMR (400 MHz, CDCl3) delta 7.60 (d, J=2.2 Hz, 1H), 6.90 (d, J=2.2 Hz, 1H), 6.03 (brs, 1H), 3.87 (s, 3H); [M+H]+ 260. |
63% | With bromine; In acetic acid; at 0 - 20℃; for 1h; | Step 4: Methyl 2-amino-5-bromo-3-methoxybenzoateTo a stirred solution of <strong>[5121-34-6]methyl 2-amino-3-methoxybenzoate</strong> (22 g, 0.121 mol) in acetic acid (220 mL) was added bromine (7.5 mL, 0.145 mol) dropwise at 0C. The reaction mixture was stirred at room temperature for 1 h. After the completion, the reaction mixture was poured into 1 L of cold water and stirred for 30 min at room temperature and extracted with ethyl acetate (2x500 mL). The combined organic layers were washed with saturated sodium bicarbonate solution (2x1 L) followed by brine solution, then dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and the crude product was purified using column chromatography (100-200 mesh silica gel, 10% EtOAc in hexane) to afford the title compound as a white solid (20 g, 63% yield).XH NMR (400 MHz, DMSO-d6) : delta 7.42 (d, J = 2.0 Hz, 1H), 7.09 (d, J = 2.0 Hz, 1H), 6.47 (brs, 2H), 3.85 (s, 3H), 3.81 (s, 3H) ; ESI-MS: Calculated mass: 258.98; Observed mass: 260.10 [M+H]+. |
27.5 g | With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0℃; for 0.5h; | To a solution of compound 53 (22.4 g 123 mmol) in DMF (250 mL) was added N-bromosuccinimide (21.9 g, 123 mmol) portionwise at 0 C. The mixture was stirred at 0 C for 0.5 h. To the mixture was added water and extracted with EtOAc (500 mL x 2). The combined organic layer was dried over MgSO4, filtered, and concentrated in vacuo. The residue was purified by silica gel column chromatography to provide the desired compound 54 (27.5 g, 86%) as a white solid. |
Tags: 5121-34-6 synthesis path| 5121-34-6 SDS| 5121-34-6 COA| 5121-34-6 purity| 5121-34-6 application| 5121-34-6 NMR| 5121-34-6 COA| 5121-34-6 structure
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P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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