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Chemical Structure| 90732-01-7 Chemical Structure| 90732-01-7

Structure of 90732-01-7

Chemical Structure| 90732-01-7

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Product Details of [ 90732-01-7 ]

CAS No. :90732-01-7
Formula : C11H8ClN
M.W : 189.64
SMILES Code : ClC1=C(C2=CC=CC=C2)C=CN=C1

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Application In Synthesis of [ 90732-01-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 90732-01-7 ]

[ 90732-01-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 77332-79-7 ]
  • [ 98-80-6 ]
  • [ 90732-01-7 ]
YieldReaction ConditionsOperation in experiment
With caesium carbonate;tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine; In 1,4-dioxane; at 95℃; for 18h; Step 2: 3-Chloro-4-phenylpyridineTo a solution of the product from Step 1 (1.3 g, 5.43 mmol), phenylboronic acid(827 mg, 6.79 mmol), PCy3 (228 mg, 0.814 mmol), and Cs2CO3 (4.25 g, 13.03 mmol) in dioxane (10 mL), Pd2(dba)3 (497 mg, 0.543 mmol) was added under N2. The mixture was then heated to 95C for 18 hours, filtered and extracted with H2O and EtOAc. The organic layer was dried over MgSO4, and the solvent was removed in vacuo. The residue was purified on SiO2 (gradient elution, 5-30% EtOAc/hexanes) to give the title compound as a colorless oil (1.03 g). LRMS ESf (M+H)+ 190.2.
 

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