Home Cart 0 Sign in  

[ CAS No. 908600-75-9 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 908600-75-9
Chemical Structure| 908600-75-9
Structure of 908600-75-9 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 908600-75-9 ]

Related Doc. of [ 908600-75-9 ]

Alternatived Products of [ 908600-75-9 ]

Product Details of [ 908600-75-9 ]

CAS No. :908600-75-9 MDL No. :MFCD12924423
Formula : C9H6FNO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 179.15 Pubchem ID :-
Synonyms :

Safety of [ 908600-75-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 908600-75-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 908600-75-9 ]

[ 908600-75-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 908600-75-9 ]
  • [ 67-56-1 ]
  • [ 1427366-38-8 ]
YieldReaction ConditionsOperation in experiment
89.5% With thionyl chloride; N,N-dimethyl-formamide at 25℃; for 12h; 1.1 Step 1 : Methyl 7-fluoro-1H-indole-6-carboxylate To a solution of 7-fluoro-l -indole-6-carboxylic acid (250 mg, 1.40 mmol, 1 eq) inDMF (0.01 mL) and MeOH (5 mL) was added SOCh (410.00 mg, 3.45 mmol, 0.25 mL, 2.47 eq) dropwise at 25 °C. The mixture was stirred at 25 °C for 12 h. TLC (PE/EtOAc = 2/1, Rf= 0.50) showed the starting material was consumed completely. The reaction mixture was concentrated under reduced pressure to yield a residue which was purified by flash silica gel chromatography (from PE/EtOAc = 100/1 to 5/1, TLC: PE/EtOAc = 2/1, Rf= 0.50) to yield methyl 7-fluoro-l//- indole-6-carboxylate (250 mg, 1.25 mmol, 89.5% yield, 96.5% purity) as a white solid. ^NMR (400 MHz, CDCh) d ppm 8.63 (br s, 1H), 7.66 (dd, J= 6.4, 8.3 Hz, 1H), 7.41 (d, J= 8.6 Hz,1H), 7.39 (t, J= 2.7 Hz, 1H), 6.64-6.60 (m, 1H), 3.96 (s, 3H); ES-LCMS m/z 194.3 [M+H]+
Same Skeleton Products
Historical Records

Related Functional Groups of
[ 908600-75-9 ]

Fluorinated Building Blocks

Chemical Structure| 1420793-98-1

[ 1420793-98-1 ]

8-Fluoro-7-methylquinoline-4-carboxylic acid

Similarity: 0.93

Chemical Structure| 908600-74-8

[ 908600-74-8 ]

5-Fluoro-1H-indole-6-carboxylic acid

Similarity: 0.93

Chemical Structure| 908600-70-4

[ 908600-70-4 ]

5-Fluoro-1H-indole-4-carboxylic acid

Similarity: 0.91

Chemical Structure| 256935-99-6

[ 256935-99-6 ]

7-Fluoro-1H-indole-5-carboxylic acid

Similarity: 0.89

Chemical Structure| 908600-72-6

[ 908600-72-6 ]

4-Fluoro-1H-indole-5-carboxylic acid

Similarity: 0.88

Carboxylic Acids

Chemical Structure| 1420793-98-1

[ 1420793-98-1 ]

8-Fluoro-7-methylquinoline-4-carboxylic acid

Similarity: 0.93

Chemical Structure| 908600-74-8

[ 908600-74-8 ]

5-Fluoro-1H-indole-6-carboxylic acid

Similarity: 0.93

Chemical Structure| 908600-70-4

[ 908600-70-4 ]

5-Fluoro-1H-indole-4-carboxylic acid

Similarity: 0.91

Chemical Structure| 256935-99-6

[ 256935-99-6 ]

7-Fluoro-1H-indole-5-carboxylic acid

Similarity: 0.89

Chemical Structure| 908600-72-6

[ 908600-72-6 ]

4-Fluoro-1H-indole-5-carboxylic acid

Similarity: 0.88

Related Parent Nucleus of
[ 908600-75-9 ]

Indoles

Chemical Structure| 908600-74-8

[ 908600-74-8 ]

5-Fluoro-1H-indole-6-carboxylic acid

Similarity: 0.93

Chemical Structure| 908600-70-4

[ 908600-70-4 ]

5-Fluoro-1H-indole-4-carboxylic acid

Similarity: 0.91

Chemical Structure| 256935-99-6

[ 256935-99-6 ]

7-Fluoro-1H-indole-5-carboxylic acid

Similarity: 0.89

Chemical Structure| 908600-72-6

[ 908600-72-6 ]

4-Fluoro-1H-indole-5-carboxylic acid

Similarity: 0.88

Chemical Structure| 1227268-61-2

[ 1227268-61-2 ]

Methyl 5-fluoro-1H-indole-6-carboxylate

Similarity: 0.85