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[ CAS No. 909302-84-7 ]

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Chemical Structure| 909302-84-7
Chemical Structure| 909302-84-7
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Product Details of [ 909302-84-7 ]

CAS No. :909302-84-7 MDL No. :MFCD11036141
Formula : C8H8BrFO Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :219.05 g/mol Pubchem ID :-
Synonyms :

Safety of [ 909302-84-7 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 909302-84-7 ]

  • Downstream synthetic route of [ 909302-84-7 ]

[ 909302-84-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 74-96-4 ]
  • [ 2040-89-3 ]
  • [ 909302-84-7 ]
YieldReaction ConditionsOperation in experiment
70% With sodium hydroxide; In ethanol; at 10℃; for 3h;Heating / reflux; 1) Synthesis of 2-fluoro-6-bromo-ethoxybenzene [E1] (Step e): e: To a 250 ml reactor were added 76.4 (0.4 mol) of <strong>[2040-89-3]2-fluoro-6-bromophenol</strong> [D1], 16 g (0.4 mol) of sodium hydroxide, and 100 ml of ethanol. After cooling to 10C, 100 ml of an ethanol solution of 48 g (0.44 ml) of bromoethane was slowly added. After the termination of the addition, they were reacted under a reflux temperature for 3 hours and, after the termination of the reaction, dichloromethane was added, followed by extraction. The extraction liquid was washed and dried and the solvent was removed by distillation to obtain 61 g of an oily product [E1]. The process yield was 70%.
70% With sodium hydroxide; In ethanol; at 10℃;Reflux; Example 3; Synthesis of 1,2-diethoxy-3-fluorobenzene [G1]; 1) Synthesis of 2-fluoro-6-bromo-ethoxybenzene [E1]; (Step e):e: To a 250 ml reactor were added 76.4 (0.4 mol) of <strong>[2040-89-3]2-fluoro-6-bromophenol</strong> [D1], 16 g (0.4 mol) of sodium hydroxide, and 100 ml of ethanol. After cooling to 10 C., 100 ml of an ethanol solution of 48 g (0.44 ml) of bromoethane was slowly added. After the termination of the addition, they were reacted under a reflux temperature for 3 hours and, after the termination of the reaction, dichloromethane was added, followed by extraction. The extraction liquid was washed and dried and the solvent was removed by distillation to obtain 61 g of an oily product [E1]. The process yield was 70%.
  • 2
  • [ 2040-89-3 ]
  • [ 75-03-6 ]
  • [ 909302-84-7 ]
YieldReaction ConditionsOperation in experiment
85% With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 24h; General procedure: To a solution of 2-bromo-4-fluorophenol (0.1 mol) in DMF (100 ml) was added K2CO3 (0.1 mol) and ethyl iodide (methyl iodide or propyl iodide) (0.1 mol) stirred 24 h at room temperature. Water (400 ml) was added and the mixture was extracted with hexane. The organic phase was washed with water, dried, filtered over a plug of silica gel and evaporated to yield the objected compound.
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