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Chemical Structure| 911845-89-1 Chemical Structure| 911845-89-1

Structure of 911845-89-1

Chemical Structure| 911845-89-1

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Product Details of [ 911845-89-1 ]

CAS No. :911845-89-1
Formula : C8H12N2
M.W : 136.19
SMILES Code : NCC1=CC=CC(C)=C1N
MDL No. :MFCD10699540

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Application In Synthesis of [ 911845-89-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 911845-89-1 ]

[ 911845-89-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1885-32-1 ]
  • [ 911845-89-1 ]
YieldReaction ConditionsOperation in experiment
31% a) 2-Aminomethyl-6-methyl-phenylamine Under an atmosphere of argon, a solution <strong>[1885-32-1]2-amino-3-methylbenzamide</strong> (1.2 g, 80 mmol) in THF (25 ml) was added to a suspension of LiAlH4 (1.52 g, 40 mmol) in THF (25 ml) over 20 min. The suspension was heated to reflux (4 h). For workup, the mixture was cooled to 0 C., and 1.5 ml H2O, 3 ml 4n NaOH, and 3 ml H2O were added subsequently. The suspension was dried (Na2SO4), and evaporated under reduced pressure. The title compound (338 mg, 31%) was isolated from the residue by chromatographic purification (silica gel, CH2Cl2/MeOH (2M NH3) =9:1). MS: m/e=136 [M+]. 1H NMR (CDCl3): delta 2.20 (3H, s), 3.92 (2H, s), 6.64 (1H, t), 6.92 (1H, d), 6.99 (1H, d).
 

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