Alternatived Products of [ 91189-05-8 ]
Product Details of [ 91189-05-8 ]
CAS No. : | 91189-05-8 |
MDL No. : | MFCD06411057 |
Formula : |
C13H20N2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
204.31
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 91189-05-8 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 91189-05-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 91189-05-8 ]
- 1
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[ 155497-10-2 ]
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[ 91189-05-8 ]
Yield | Reaction Conditions | Operation in experiment |
90% |
With lithium aluminium tetrahydride; In tetrahydrofuran; at -5.0℃;Heating / reflux; |
To a cooled (-5C) and stirred solution of LAH (1 M, 7.6 ml) in dry THF (75 ml) was added a solution of (1-BENZYL-PYRROLIDIN-3-YLMETHYL)-CARBAMIC acid TERT-BUTYL ester (1.47 g, 5.06 mmol) in THF (22 ml) over 20 minutes. The mixture was then heated at reflux for 2.5 hrs and cooled to room temperature and quenched by successive addition of ethyl acetate (50 ml). The organic layer was then washed with water (2X), 10% NAOH and brine, dried and evaporated to give the desired product in 90% yield |
- 2
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[ 91189-05-8 ]
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[ 427-49-6 ]
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N-(l-benzyl-pvrrolidin-3-vlmethvf)-2-cvclopentvl-2-hvdroxv-N-methyl-2-phenyl-acetamide
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
75.34% |
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Example 8: Synthesis of N-(l-benzyl-pvrrolidin-3-vlmethvf)-2-cvclopentvl-2-hvdroxv-N-methyl-2-phenyl-acetamide (Compound No. 25)To a solution of the compound 2-cyclopentyl-2-hydroxy-2-phenyl acetic acid (leq.) in dimethylformamide was added hydroxybenzotriazole (1.5eq.), l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (leq.) and dimethylaminopyridine (catalytic amount). The reaction mixture was stirred at 15-20C for 2 hours followed by the addition of N-methylmorpholine (2 eq.) and a solution of the compound (l-benzyl-pyrrolidin-3-ylmethyl)-methyl-amine (1 eq.) in dimethylformamide (10 ml). The resulting reaction mixture was stirrei 15-20C for 1 hour and subsequently at room temperature for 14 hours. To the mixture was ad water and stirred for 15 minutes. The aqueous layer was extracted with ethylacetate. The orgar layer was washed with sodium bicarbonate solution, water and brine, dried over anhydrous sodium sulphate and concentrated under reduced pressure. The residue thus obtained was purii by column chromatography to furnish the title compound. Yield: 75.34%.Mass(nVz): 407.0 (M++l).IR: 1623.8 cm-1, 2951.2 cm-1, 3357.5 cm-1.'HNMR: 1.256-1.663 (m, 10H), 2.014-2.559 (m, 6H), 2.713-2.951 (m, 4H), 3.399-3.461 (m, 2H), 3.801 (s, 2H), 7.105-7.334 (m, 10H). |