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Chemical Structure| 91367-10-1 Chemical Structure| 91367-10-1

Structure of 91367-10-1

Chemical Structure| 91367-10-1

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Product Details of [ 91367-10-1 ]

CAS No. :91367-10-1
Formula : C9H9ClO3
M.W : 200.62
SMILES Code : O=C(O)CC1=CC(OC)=CC=C1Cl
MDL No. :MFCD09925191

Safety of [ 91367-10-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 91367-10-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 91367-10-1 ]

[ 91367-10-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13671-00-6 ]
  • [ 91367-10-1 ]
  • 2-(2-chloro-5-methoxyphenyl)-1-(2,6-difluorophenyl)ethanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
2.58 g Step 1: Synthesis of 2-(2-chloro-5-methoxyphenyl)-1-(2,6-difluorophenyl)ethanone After 30 ml of a THF solution containing 2.05 g of 2-(2-chloro-5-methoxyphenyl)acetic acid was cooled to -78 C., 17.21 ml of 1.9 mol/L of a THF solution of hexamethyldisilazane sodium was added dropwise thereto at -50 C. or lower, and the mixture was stirred at -78 C. for 40 minutes. After 10 ml of a THF solution containing 1.76 g of <strong>[13671-00-6]methyl 2,6-difluorobenzoate</strong> was added dropwise thereto at -78 C., the temperature was allowed to warm to room temperature, and the mixture was stirred for 1.5 hours. To the reaction mixture was added a saturated aqueous ammonium chloride solution, the mixture was stirred, and then ethyl acetate was added to separate the resulting mixture. The obtained organic layer was washed with brine and dried over sodium sulfate. After the solvent was distilled off under reduced pressure, the resulting residue was purified by silica gel column chromatography to obtain the title compound as 2.58 g of a yellow oil. 1H-NMR (CDCl3) delta: 7.40-7.38 (1H, m), 7.28-7.27 (1H, m), 6.96-6.94 (2H, m), 6.83 (1H, d, J=3.1 Hz), 6.78 (1H, dd, J=8.9, 3.1 Hz), 4.27 (2H, s), 3.79 (3H, s).
 

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