913835-98-0|(6-(Hydroxymethyl)pyridin-3-yl)boronic acid| Ambeed

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Yield	Reaction Conditions	Operation in experiment
	With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate; In 1,4-dioxane; for 6h;Reflux;	<strong>[927801-23-8]6-bromo-4-iodoquinoline</strong> 6 (212.37, 0.636 mmol) and 2-(Hydroxymethyl)pyridine-5-boronic acid 7 (150 mg, 0.636 mmol) was dissolved in anhydrous l,4-dioxane (15 mL). To this was added Pd(dppfhCl2 (19.9 mg, 0.024 mmol) followed by 2M Na2C03 (2.5 mL). The mixture was then heated at reflux for 6 hrs. After cooling to room temperature the solids were filtered off and evaporated. The crude product was purified by flash chromatography (EtOAc:MeOH) to give compound 8. LRMS-LC/MS (m/z): [M + H] + calcd for CisHiiBrN20, 314; found 315)

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Environmental hazards
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H401	Toxic to aquatic life
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H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

CAS No. :	913835-98-0	MDL No. :	MFCD09027230
Formula :	C₆H₈BNO₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	152.94	Pubchem ID :	-
Synonyms :

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

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[ 913835-98-0 ] Synthesis Path-Downstream 1~1

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