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[ CAS No. 914610-50-7 ]

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Chemical Structure| 914610-50-7
Chemical Structure| 914610-50-7
Structure of 914610-50-7 * Storage: {[proInfo.prStorage]}

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Product Details of [ 914610-50-7 ]

CAS No. :914610-50-7 MDL No. :MFCD06657824
Formula : C15H22BNO4S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :323.22 g/mol Pubchem ID :-
Synonyms :

Safety of [ 914610-50-7 ]

Signal Word:Warning Class:
Precautionary Statements:P264-P270-P301+P312+P330-P501 UN#:
Hazard Statements:H302 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 914610-50-7 ]

  • Downstream synthetic route of [ 914610-50-7 ]

[ 914610-50-7 ] Synthesis Path-Downstream   1~10

  • 2
  • [ 1072-97-5 ]
  • [ 914610-50-7 ]
  • [ 1396776-95-6 ]
YieldReaction ConditionsOperation in experiment
35% With sodium carbonate In water; acetonitrile at 80 - 100℃; Microwave irradiation; 6.23 A mixture of 2-amino-5-bromopyridine (3.58 g, 20.7 mmol), N-cyclopropyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzenesulfonamide (5.00 g, 20.7 mmol), sodium carbonate (3.29 g, 31.05 mmol), and PdCl2(PPh3)2 (0.436 g, 0.62 mmol) in 3:1 acetonitrile:water was microwave heated at 80° C. for 20 min, and then at 100° C. for 15 min. The reaction was then heated in an oil bath at 80° C. for 16 h. The reaction was cooled to room temperature and filtered. The solid was washed with methanol (10 mL), and the combined filtrates were concentrated. The crude material was purified by flash chromatography over silica gel (0-5% MeOH/DCM) to give 4-(6-aminopyridin-3-yl)-N-cyclopropylbenzenesulfonamide (2.08 g, 35% yield). 1H NMR (400 MHz, METHANOL-d4) δ ppm 8.27 (d, J=2.01 Hz, 1H), 7.88-7.95 (m, 2H), 7.85 (d, J=2.51 Hz, 1H), 7.81-7.84 (m, 1H), 7.71-7.79 (m, 2H), 6.45-6.88 (m, 1H), 1.89-2.41 (m, 1H), 0.13-0.82 (m, 4H); MS (EI) m/z: 290 [M+H]+. HPLC (Sunfire C18 4.6 mm×50 mm, 10-90% MeCN:10 mM aq. NH4OAc, 2 min gradient) tR=1.34 min, 88% integrated area.
  • 3
  • [ 914610-50-7 ]
  • [ 1396776-37-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 80 - 100 °C / Microwave irradiation 2: N-Bromosuccinimide / dichloromethane / 1 h 3: tricyclohexylphosphine; potassium acetate / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 80 °C 4: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 0.1 h / 150 °C / Microwave irradiation
  • 4
  • [ 914610-50-7 ]
  • [ 1396776-34-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 80 - 100 °C / Microwave irradiation 2: N-Bromosuccinimide / dichloromethane / 1 h
  • 5
  • [ 914610-50-7 ]
  • [ 1396776-98-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 80 - 100 °C / Microwave irradiation 2: N-Bromosuccinimide / dichloromethane / 1 h 3: tricyclohexylphosphine; potassium acetate / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 80 °C
  • 6
  • [ 914610-50-7 ]
  • 1-((5-bromo-4-methylpyridin-2-yl)methyl)-5-(tert-butyl)-3-(2-ethoxy-6-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazinan-2-one [ No CAS ]
  • C25H26F3N5O4S [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium hydroxide / 1,4-dioxane; water / 0.17 h / 130 °C / Microwave irradiation 2: potassium hydroxide / water / 0.17 h / 130 °C / Microwave irradiation
  • 7
  • [ 914610-50-7 ]
  • 1-((5-bromo-4-methylpyridin-2-yl)methyl)-5-(tert-butyl)-3-(2-ethoxy-6-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazinan-2-one [ No CAS ]
  • C31H37F3N6O4S [ No CAS ]
YieldReaction ConditionsOperation in experiment
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium hydroxide In 1,4-dioxane; water at 130℃; for 0.166667h; Microwave irradiation;
  • 8
  • 4-bromo-N-cyclopropylbenzenesulfonamide [ No CAS ]
  • [ 73183-34-3 ]
  • [ 914610-50-7 ]
YieldReaction ConditionsOperation in experiment
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In N,N-dimethyl-formamide at 85℃;
  • 9
  • [ 914610-50-7 ]
  • [ 944904-46-5 ]
  • N-cyclopropyl-4-(6-fluoro-1H-indazol-3-yl)benzenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
28% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,4-dioxane; water at 120℃; for 1h; Microwave irradiation; Inert atmosphere; Alkaline conditions;
  • 10
  • [ 98-58-8 ]
  • [ 914610-50-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 2,6-dimethylpyridine / 0 °C 2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 85 °C
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