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Chemical Structure| 916429-26-0 Chemical Structure| 916429-26-0

Structure of 916429-26-0

Chemical Structure| 916429-26-0

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Product Details of [ 916429-26-0 ]

CAS No. :916429-26-0
Formula : C9H4BrClIN
M.W : 368.40
SMILES Code : IC1=CC2=CC(Br)=CC=C2N=C1Cl
MDL No. :MFCD26400119

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Application In Synthesis of [ 916429-26-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 916429-26-0 ]

[ 916429-26-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 916429-26-0 ]
  • [ 819849-22-4 ]
  • 3-(3-N,N-dimethylaminomethyl)phenyl-2-chloro-6-bromoquinoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
84.78% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In toluene; at 80.0℃; for 10.0h; 2-chloro-6-bromo-3-iodoquinoline (600 mg, 1.64 mmol) was dissolved in 3 mL of toluene, Pd(PPh3)4 (37 mg, 0.033 mmol) was added successively,Sodium carbonate (260 mg, 2.45 mmol) in 0.3 mL of water,<strong>[819849-22-4]3-dimethylaminomethylbenzeneboronic acid</strong> (440 mg, 2.45 mmol),The reaction mixture was stirred at 80 C for 10 hours. To the residue was added 20 mL of water and extracted with dichloromethane (20 mL * 3). The organic phase was combined and purified by column chromatography (dichloromethane / methanol 15: 1)To obtain 520 mg of a light yellow solid, yield 84.78%
 

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