Home Cart 0 Sign in  

[ CAS No. 916791-07-6 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 916791-07-6
Chemical Structure| 916791-07-6
Structure of 916791-07-6 * Storage: {[proInfo.prStorage]}

Quality Control of [ 916791-07-6 ]

Related Doc. of [ 916791-07-6 ]

SDS
Alternatived Products of [ 916791-07-6 ]
Alternatived Products of [ 916791-07-6 ]

Product Details of [ 916791-07-6 ]

CAS No. :916791-07-6 MDL No. :MFCD08752648
Formula : C4H2BrClN2 Boiling Point : 210.5°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :193.43 g/mol Pubchem ID :-
Synonyms :

Safety of [ 916791-07-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 916791-07-6 ]

  • Downstream synthetic route of [ 916791-07-6 ]

[ 916791-07-6 ] Synthesis Path-Downstream   1~14

  • 1
  • [ 916791-07-6 ]
  • [ 1066-54-2 ]
  • [ 1207852-41-2 ]
YieldReaction ConditionsOperation in experiment
80% With copper(l) iodide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 23℃; 6 Preparation of compound 6a: 2-Chloro-6-(2-(trimethylsilyl)ethynyl)pyrazineA mixture of 2-bromo-6-chloropyrazine (0.976 g, 5 mmol), Pd(PPh3)2CI2 (0.106 g, 0.15 mmol), DIEA (0.646 g, 5 mmol) and CuI (0.095 g, 0.5 mmol) in DMF was purged with nitrogen and treated with thmethylsilylacetylene (0.491 g, 5 mmol). The resultant mixture was stirred at 23 0C overnight. The reaction mixture was poured into saturated aqueous NaHCO3 and extracted with EtOAc. The organic layer was washed with brine, dried over Na2SO4, decanted and concentrated under reduced pressure. The crude product was purified by flash chromatography on silica gel (0- 20% EtOAc-hexanes) which gave the title compound 6a as a clear oil (861 mg, 80% yield). 1 H NMR (400 MHz, MeOD) δ ppm 8.62 (s, 1 H),, 8.61 (s, 1 H), 0.29 (s, 9 H).
42% With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 50℃; for 5h;
  • 2
  • [ 916791-07-6 ]
  • [ 274-79-3 ]
  • [ 1207852-40-1 ]
YieldReaction ConditionsOperation in experiment
55% With potassium carbonate; triphenylphosphine;palladium diacetate; In 1,4-dioxane; at 75℃; for 24h; Preparation of compound 4a: 3-(6-Chloropyrazin-2-yl)<strong>[274-79-3]imidazo[1,2-a]pyrazine</strong>A mixture of imidazo[1 ,2-a]pyrazine (2.0 g, 16.8 mmol), 2-bromo-6-chloropyrazine (4.9 g, 25.2 mmol), palladium (II) acetate (0.78 g, 3.36 mmol), thphenylphosphine (0.45 g, 1.7 mmol), and potassium carbonate (2.3 g, 16.8 mmol) in dioxane (40 mL) was heated at 75 0C for 24 h. The reaction was filtered hot, rinsed with dioxane, and the filtrate was concentrated under reduced pressure. The product was recrystallized from EtOAc which gave the title compound 4a as a beige solid (2.2 g, 55% yield). 1 H NMR (400 MHz, DMSO-c/6) delta ppm 9.43 (s, 2 H), 9.29 (s, 1 H), 8.87 (s, 1 H), 8.72 (s, 1 H), 8.23 (s, 1 H).
  • 3
  • [ 916791-07-6 ]
  • [ 274-71-5 ]
  • [ 1207852-87-6 ]
YieldReaction ConditionsOperation in experiment
5% With caesium carbonate; triphenylphosphine;palladium diacetate; In 1,4-dioxane; for 72.0h;Reflux; Preparation of compound 23b: 3-(6-Chloro-pyrazin-2-yl)-pyrazolo[1,5- ajpyrimidineTo a stirred solution of 23a (30 g, 0.252 mol), 2-bromo-6-chloro-pyrazine (58.5 g, 0.302 mol) and PPh3 (6.6 g, 0.0252 mol) in dioxane (300 ml_) was added Cs2CO3 (82.1 g, 0.252 mol) and Pd(OAc)2 (11.3 g, 0.0504 mol). The mixture was purged with N2 x3 and stirred at reflux for 3 days. The reaction mixture was cooled to room temperature and filtered. The filtrate was concentrated, and the resulting residue was purified via preparative HPLC which gave the title compound 23b as a yellow solid (3.01 g, 5%).
  • 4
  • [ 1111638-43-7 ]
  • [ 916791-07-6 ]
  • [ 1401732-24-8 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate In ethanol; water at 80℃; Inert atmosphere; Sealed tube; 28 Reaction Scheme 5EXAMPLE 28: 5 -(6-chloropyrazin-2-ylVl-(4-methoxybenzylV3 -methyl- 1 H- pyrazolor3,4-b1 pyridineTo a stirred solution of (l-(4-methoxybenzyl)-3-methyl-5-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)-lH-pyrazolo[3,4-b]pyridine) 8 (105 mg, 0.276 mmol) and 2-bromo-6- chloropyrazine 40 (50 mg, 0.268 mmol, 1 equivalent) in DME (3 mL), ethanol (0.5 mL) and water (0.1 mL) was added sodium carbonate (2.0 M, 0.561 mmol, 2 equivalent) and degassed for 10 min followed by charging Pd(PPh3)4 (9.5 mg, 0.0082 mmol, 0.03 equivalent). The resulting reaction mixture was purged with N2 and degassing was submitted for heating at 80°C overnight under pressure in a sealed tube. After completion of the reaction the reaction was diluted with ethyl acetate and water. The organic layer was separated and aqueous phase was extracted with ethyl acetate. The combined organic layer was washed with brine and dried over sodium sulphate and evaporated. The crude product was flash chromatographed with 100-200 mesh silica gel eluting the pure compound at 40% ethyl acetate in hexane as off white coloured solid of compound 41 in 25 mg. The product 41 was confirmed by LCMS. MS: 365.9, (M+l).
  • 5
  • [ 916791-07-6 ]
  • N-(3-hydroxy-3-methylbutyl)-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide [ No CAS ]
  • 3-(6-chloropyrazin-2-yl)-N-(3-hydroxy-3-methylbutyl)-4-methylbenzenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
73% With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate In 1,2-dimethoxyethane at 80℃; for 3h; Inert atmosphere; Intermediate D1: 3-(6-Chloro-pyrazin-2-yl)-N-(3-hydroxy-3-methyl-butyl)-4-methyl-benzenesulfonamide A stirred solution of N-(3-hydroxy-3-methylbutyl)-4-methyl-3-(4,4,5,5-tetramethyl-1 ,3,2- dioxaborolan-2-yl)benzenesulfonamide (Intermediate B3) (1 .98 g, 5.17 mmol) and 2-bromo-6- chloropyrazine (1 .0 g, 5.17 mmol) in DME (10 ml) and 2M Na2C03 (7.8 ml, 15.5 mmol) was degassed several times under nitrogen before addition of PdCI2(dppf).CH2CI2 adduct. (0.21 1 g, 0.26 mmol). The mixture was de-gassed again then heated at 80°C. After 3h the solvent was removed and the residue was partitioned between EtOAc and water. The organic extract was removed, dried over MgS04 and the solvent removed to give a brown residue. Chromatography on silica, eluting with EtOAc, gave the product as a colourless gum (1 .401 g, 73 %) (0605) LCMS: RT 0.95 mins,; MS m/z 370.4 [2M+H]+; Method 2minl_C_v003.olp (0606) 1 H NMR (400MHz, d6-DMSO) δ 8.96 (1 H, s), 8.86 (1 H, s), 7.90 (1 H, s), 7.82 (1 H, s), 7.63 (1 H, d), 7.99 (1 H, br t), 4.28 (1 H, s), 2.83 (2H, m), 2.45 (3H, s), 1 .50 (2H, m), 1 .00 (6H, s)
  • 6
  • [ 916791-07-6 ]
  • [ 1218791-01-5 ]
  • N-(3-hydroxypropyl)-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide [ No CAS ]
  • N-(3-hydroxy-propyl)-4-methyl-3-[6-(2-methylthiazol-5-yl)-pyrazin-2-yl]-benzenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
To a 2-5ml microwave vial was added 2-methyl-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2- yl)thiazole (1 16 mg, 0.517 mmol), 2-bromo-6-chloropyrazine (100 mg, 0.517 mmol), Na2C03 (0.775ml, 1 .551 mmol, 2M ) and PdCI2(dppf). CH2CI2 adduct (21 mg, 0.026mmol) in DME (3 ml) to give an orange suspension. The reaction was heated in a biotage initiator microwave at 120C for 60mins. To the reaction was added N-(3-hydroxypropyl)-4-methyl-3-(4, 4,5,5- tetramethyl-1 ,3,2-dioxaborolan-2-yl)benzenesulfonamide (Intermediate B1) (184mg, 0.517mmol) and PdCI2(dppf)CH2Cl2adduct (21 mg, 0.026mmol). The reaction was heated at 120C in a microwave for 60mins. The reaction was extracted into ethyl acetate, washed with water, brine, dried over MgS04, filtered and the solvent removed under reduced pressure. The crude product was loaded onto silica and purified by flash column chromatography using a Teledyne ISCO combiflash Rf, elution with TBME:MeOH (0-20%) over 15mins on a 12g silica cartridge. The required fractions were combined and the solvent removed under reduced pressure to yield a brown oil which was dried under reduced pressure at 40C for 2 hours. The product was isolated as a brown solid. (0478) LCMS: Rt 0.86mins; MS m/z 405.2 [M+H]+; Method LowpH_v002. (0479) 1H NMR (400MHz, DMSO) delta (ppm) 9.30 (1 H, s), 8.78 (1 H, s), 8.57 (1 H, s), 7.91 (1 H, d), 7.82- 7.79 (1 H, dd), 7.63-7.61 (1 H, d), 7.57-7.54 (1 H, m), 4.42-4.40 (1 H, m), 3.40-3.35 (2H, m), 2.85- 2.80 (2H, m), 2.72 (3H, s), 2.49 (3H, s), 1 .57-1 .51 (2H, m).
  • 7
  • [ 916791-07-6 ]
  • [ 1046832-21-6 ]
  • 2-chloro-6-(1,3-dimethyl-1H-pyrazol-4-yl)pyrazine [ No CAS ]
YieldReaction ConditionsOperation in experiment
46% With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; at 70℃; for 3h;Inert atmosphere; Sodium carbonate (33 ml of a 2M solution, 67 mmol) was added to a mixture of 2-bromo-6- chloropyrazine (4.8 g, 25 mmol), 1 ,3-dimethyl-4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)- 1 H-pyrazole (5.0 g, 22.3 mmol) and PdCI2(PPh3)2 (0.79 g, 67 mmol) in DME (80 ml). The mixture was de-gassed several times under nitrogen then heated with stirring at 70C for 3h. The solvent was removed in vacuo and the residue was diluted with brine and extracted several times with EtOAc. The combined organic extract was separated, dried (MgS04) and the solvent concentrated in vacuo whereupon the product precipitated (2.21 g, 46%). The solid was collected by filtration and washed with diethyl ether - hexane. (0585) LC-MS: Rt 0.90 mins; MS m/z 209.4 [M+H]+; Method 2minl_owpH_v01 (0586) 1 H NMR (400 MHz, CDCI3) delta 8.64 (1 H, s), 8.43 (1 H, s), 7.92 (1 H, s), 3.92 (3H, s), 2.57 (3H, s).
  • 8
  • [ 621-23-8 ]
  • [ 916791-07-6 ]
  • 2-chloro-6-(2,4,6-trimethoxyphenyl)pyrazine [ No CAS ]
YieldReaction ConditionsOperation in experiment
79% With potassium carbonate In acetonitrile at 20℃; for 24h; Inert atmosphere; UV-irradiation;
  • 9
  • [ 131-11-3 ]
  • [ 916791-07-6 ]
  • methyl 2-(6-chloropyrazin-2-carbonyl)benzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
60% Stage #1: 2-bromo-6-chloropyrazine With n-butyllithium In diethyl ether at -78℃; for 1h; Inert atmosphere; Stage #2: phthalic acid dimethyl ester In diethyl ether for 2h; 1 Example 1Intermediate Methyl 2- (6-chloro-pyrazine-2-carbonyl) benzoate (A-1)Preparation A mixture of 2-bromo-6-chloro-pyrazine (19.3g, 0.1mol) dissolved in 300mL of anhydrous ethyl ether, dry ice bath -78 deg.] C, nitrogen atmosphere, was added 44mL of BuLi (2.5M), the reaction was stirred for 1 hour, then add dimethyl phthalate (19.4g, 0.1mol), react for 2 hours, then gradually warmed to room temperature, water was added to terminate the reaction. After the treatment process: dispensing system, points to the water layer, the aqueous layer extracted with ethyl acetate again, and the combined organic layers were spin-dry organic solvent, methylene chloride: petroleum ether = 9: 1 (by volume) through the column separation, as a white solid (A-1) (16.6g, y (yield) = 60%).
  • 10
  • [ 916791-07-6 ]
  • lithium (6-(1,3-dioxolan-2-yl)pyridin-2-yl)trihydroxyborate [ No CAS ]
  • 2-chloro-6-(6-[1,3]dioxolan-2-ylpyridin-2-yl)pyrazine [ No CAS ]
YieldReaction ConditionsOperation in experiment
21% With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; tricyclohexylphosphine In 1,4-dioxane; water at 85℃; for 24h; Inert atmosphere; Sealed tube; C72.i C72. i. 2-chloro-6-(6-[1, 3Jdioxolan-2-yl-pyridin-2-yl)-pyrazine: To a mixture of 2-bromo-6-chloropyrazine (100 mg) and the compound ofPreparation BB11 (113 mg) in dioxane (1.2 mL) was added a solution of K2C03 (143 mg)in water (0.4 mL). The resulting suspension was degassed with N2 for 10 mm, tris(dibenzylideneacetone)-dipalladium(0) (23.7 mg) and PCy3 (17.4 mg) were added, the reaction flask was sealed and heated at 85°C for 1 day. Water and EA were added, the layers were separated and the aq. layer was extracted twice with EA. The combined org.extracts were dried (Mg504), filtered and concentrated under reduced pressure. The title compound was obtained, after purification by CC (Combiflash; Hept to Hept/EA 1:1), as a yellowish oil (29 mg, 21% yield).M53 (ESI, mlz): 263.97 [M+Hj; tR = 0.79 mm.
  • 11
  • [ 916791-07-6 ]
  • 3,3-dimethyl-6-(2-methylpyrimidin-5-yl)indolin-2-one [ No CAS ]
  • 1-(6-chloropyrazin-2-yl)-3,3-dimethyl-6-(2-methylpyrimidin-5-yl)indolin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
46% With copper(l) iodide; trans-N,N-dimethylcyclohexane-1,2-diamine; potassium carbonate In 1,4-dioxane at 110℃; for 20h; Inert atmosphere; 4.a a) l-(6-Chloropyrazin-2-yl)-3 -dimethyl-6-(2-methylpyrimidin-5-yl)indolm 3,3-Dimethyl-6-(2-methylpyrimidin-5-yl)indolin-2-one (3 g, 11.8 mmol, Eq: 1, (0203) WO2014/202493 Al), 2-bromo-6-chloropyrazine (2.98 g, 15.4 mmol, Eq: 1.30), copper (I) iodide (226 mg, 1.18 mmol, Eq: 0.10), potassium carbonate (3.27g, 23.7 mmol, Eq: 2) and trans- N,N-dimethylcyclohexane 1,2- diamine (347 mg, 385 μ, 2.37 mmol, Eq: 0.20) were combined with degassed 1,4-dioxane (30 ml) under inert atmosphere. The reaction mixture was heated to 110 °C and stirred for 20h. The reaction mixture was poured into saturated sodium bicarbonate and extracted with ethyl acetate (2x). The organic layers were combined and washed with water and brine and finally dried over sodium sulfate then filtered and evaporated in vacuo. (0204) The residue was purified by chromatography on silica gel to afford the desired product as a white solid (2 g, 46 %). MS (m/z) = 366.2 [(M+H)+].
46% With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate In 1,4-dioxane at 110℃; for 20h; Inert atmosphere; 2.a a) 1-(6-chloropyrazin-2-yl)-3-dimethyl-6-(2-methylpyrimidin-5-yl)indolin-2-one 3,3-dimethyl-6-(2-methylpyrimidin-5-yl)indolin-2-one (3 g, 11.8 mmol, Eq: 1, WO2014/202493 Al), 2-bromo-6-chloropyrazine (2.98 g, 15.4 mmol, Eq: 1.30), copper (I) iodide (226 mg, 1.18 mmol, Eq: 0.10), potassium carbonate (3.27g, 23.7 mmol, Eq: 2) and trans- N,N-dimethylcyclohexane 1,2- diamine (347 mg, 385 μ, 2.37 mmol, Eq: 0.20) were combined with degassed 1,4-dioxane (30 ml) under inert atmosphere. The reaction mixture was heated to 110 °C and stirred for 20 h. The reaction mixture was poured into saturated sodium bicarbonate and extracted with ethyl acetate (2x). The organic layers were combined and washed with water and brine and finally dried over sodium sulfate then filtered and evaporated in vacuo. The residue was purified by chromatography on silica gel to afford the desired product as a white solid (2 g, 46%). MS (m/z) = 366.2 [M + H]+.
  • 12
  • [ 916791-07-6 ]
  • tert-butyl (3R)-3-{(3-chloropyridin-2-yl)[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl]amino}piperidine-1-carboxylate [ No CAS ]
  • (R)-tert-butyl 3-(N-(3-chloropyridin-2-yl)-4-(6-chloropyrazin-2-yl)benzamido)piperidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
58% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In 1,4-dioxane; water at 100℃; for 4h; Inert atmosphere;
  • 13
  • [ 916791-07-6 ]
  • tert-butyl (2-(3-(2-(5 -(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-indazol-3-yl)-1H-benzo[d]imidazol-4-yl)phenoxy)ethyl)carbamate [ No CAS ]
  • tert-butyl (2-(3-(2-(5-(6-chloropyrazin-2-yl)-1-trityl-1H-indazol-3-yl)-1H-benzo[d]imidazol-4-yl)phenoxy)ethyl)carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
86.3% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate In 1,4-dioxane; water at 110℃; for 0.5h; Inert atmosphere; Microwave irradiation; 6.2 Step 2 A mixture of tert-butyl (2-(3-(2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan- 2-yl)-1-trityl-1H-indazol-3-yl)-1H-benzo[d]imidazol-4-yl)phenoxy)ethyl)carbamate (CXVII) (412 mg, 0.49 mmol), Pd(dppf)Cl2 (20 mg, 0.02 mmol), a 2 M aqueous solution of K3PO4 (0.7 mL, 1.4 mmol), and 2-bromo-6-chloropyrazine (CXVIII) (190 mg, 0.98 mmol) in dioxane (10 mL) in a sealed vial was purged with N2 gas for 10 min and irradiated with microwave at 110oC for 30 minutes. The organic layer was separated and concentrated, the residue was purified by column chromatography (02% MeOH/CHCl3) to obtain tert-butyl (2-(3-(2-(5-(6-chloropyrazin- 2-yl)-1-trityl-1H-indazol-3-yl)-1H-benzo[d]imidazol-4-yl)phenoxy)ethyl)carbamate (CXIX) (350 mg, 0.42 mmol, 86.3% yield) as a brown solid.1H NMR (500 MHz, DMSO-d6) d ppm 1.31 (9 H, s), 3.18 - 3.24 (2 H, m), 4.05 (2 H, br t, J=5.90 Hz), 6.59 (1 H, d, J=9.33 Hz), 6.90 (1 H, br t, J=5.21 Hz), 7.00 (1 H, dd, J=8.10, 2.06 Hz), 7.31 - 7.37 (9 H, m), 7.37 - 7.43 (6 H, m), 7.48 - 7.55 (2 H, m), 7.58 (1 H, dd, J=7.96, 0.82 Hz), 7.82 (1 H, s), 7.92 (1 H, dd, J=9.19, 1.78 Hz), 7.97 (1 H, br d, J=7.68 Hz), 8.74 (1 H, s), 9.21 (1 H, s), 9.42 (1 H, d, J=1.10 Hz), 12.80 (1 H, s); ESIMS found for C50H42ClN7O3 m/z 824.15 (M+1).
  • 14
  • [ 100-55-0 ]
  • [ 916791-07-6 ]
  • 2-Chloro-6-(3-Pyridinylmethoxy)Pyrazine [ No CAS ]
  • C10H8BrN3O [ No CAS ]
YieldReaction ConditionsOperation in experiment
1: 9.4% 2: 15% With sodium hydride In 1,4-dioxane; mineral oil at 20℃; for 2h; Inert atmosphere; 1.V Synthetic Method V: Synthesis of Example 188 and 189 R-26 (0.22 mL, 1.03 mmol) and R-27 (113 mg, 1.03 mmol) are suspended in 1,4- dioxane (2 mL) and to this is added sodium hydride (60%, 45 mg, 1.14 mmol). The resulting mixture is left to stir for 2 hours at room temperature under a nitrogen atmosphere. The reaction is cooled to room temperature and quenched with water (5 mL), partitioned between ethyl acetate (20 mL) and brine (20 mL). The organic phase is separated and concentrated in vacuo. The crude material is purified by preparative HPLC afford Example 188 (26 mg, 9.4%) and Example 189 (35 mg, 15%).
Historical Records

Related Functional Groups of
[ 916791-07-6 ]

Chlorides

Chemical Structure| 912773-21-8

[ 912773-21-8 ]

2-Bromo-5-chloropyrazine

Similarity: 0.97

Chemical Structure| 21943-16-8

[ 21943-16-8 ]

2,5-Dibromo-3-chloropyrazine

Similarity: 0.91

Chemical Structure| 1082843-70-6

[ 1082843-70-6 ]

3,5-Dibromo-2-chloropyrazine

Similarity: 0.89

Chemical Structure| 1206250-01-2

[ 1206250-01-2 ]

2-Bromo-3-chloropyrazine

Similarity: 0.89

Chemical Structure| 1206249-40-2

[ 1206249-40-2 ]

2-Bromo-3,5-dichloropyrazine

Similarity: 0.86

Bromides

Chemical Structure| 912773-21-8

[ 912773-21-8 ]

2-Bromo-5-chloropyrazine

Similarity: 0.97

Chemical Structure| 21943-16-8

[ 21943-16-8 ]

2,5-Dibromo-3-chloropyrazine

Similarity: 0.91

Chemical Structure| 1082843-70-6

[ 1082843-70-6 ]

3,5-Dibromo-2-chloropyrazine

Similarity: 0.89

Chemical Structure| 1206250-01-2

[ 1206250-01-2 ]

2-Bromo-3-chloropyrazine

Similarity: 0.89

Chemical Structure| 1206249-40-2

[ 1206249-40-2 ]

2-Bromo-3,5-dichloropyrazine

Similarity: 0.86

Related Parent Nucleus of
[ 916791-07-6 ]

Pyrazines

Chemical Structure| 912773-21-8

[ 912773-21-8 ]

2-Bromo-5-chloropyrazine

Similarity: 0.97

Chemical Structure| 21943-16-8

[ 21943-16-8 ]

2,5-Dibromo-3-chloropyrazine

Similarity: 0.91

Chemical Structure| 1082843-70-6

[ 1082843-70-6 ]

3,5-Dibromo-2-chloropyrazine

Similarity: 0.89

Chemical Structure| 1206250-01-2

[ 1206250-01-2 ]

2-Bromo-3-chloropyrazine

Similarity: 0.89

Chemical Structure| 1206249-40-2

[ 1206249-40-2 ]

2-Bromo-3,5-dichloropyrazine

Similarity: 0.86