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Chemical Structure| 918643-41-1 Chemical Structure| 918643-41-1

Structure of 918643-41-1

Chemical Structure| 918643-41-1

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Product Details of [ 918643-41-1 ]

CAS No. :918643-41-1
Formula : C13H8FIN2OS
M.W : 386.18
SMILES Code : NC1=CC=C(OC2=C3C(C=C(I)S3)=NC=C2)C(F)=C1

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Application In Synthesis of [ 918643-41-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 918643-41-1 ]

[ 918643-41-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 389621-84-5 ]
  • [ 918643-41-1 ]
  • (4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)phenyl)(morpholino)methanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
12% With caesium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,2-dimethoxyethane; at 85℃; for 18h; Example 130; N-(3-fluoro-4-(2-(4-(morpholine-4-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; Step A: Preparation of (4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)phenyl)(morpholino)methanone; A sealable tube was charged with 3-fluoro-4-(2-iodothieno[3,2-b]pyridin-7-yloxy)aniline (Example 6, Step A, 0.200 g, 0.518 mmol), cesium carbonate (0.253 g, 0.777 mmol), <strong>[389621-84-5]4-(morpholine-4-carbonyl)phenylboronic acid</strong> (0.183 g, 0.777 mmol) and DME (2 mL). The mixture was degassed under nitrogen for 10 minutes and Pd(PPh3)4 (0.0299 g, 0.0259 mmol) was added as a solid. The mixture was heated to 85 C. for 18 hours. The crude was diluted with water (300 mL), extracted with EtOAc/MeOH (4:1, 2×300 mL), dried organic over sodium sulfate, filtered and concentrated. The crude product was purified by preparative TLC (2.0 mm thickness) eluting with EtOAc/MeOH (9:1) to give product (31 mg, 12%) as a white solid. LRMS (APCI+) 450 m/z (M+1) detected.
 

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