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CAS No. : | 92352-24-4 | MDL No. : | MFCD20275076 |
Formula : | C8H8N4O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | WDPPKVUTTXCXMM-UHFFFAOYSA-N |
M.W : | 192.17 | Pubchem ID : | 3649375 |
Synonyms : |
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Signal Word: | Warning | Class: | |
Precautionary Statements: | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501 | UN#: | |
Hazard Statements: | H302-H312-H332 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | With trichlorophosphate at 45℃; for 0.633333h; Sonication; Green chemistry; | General procedures for the synthesisof compounds 7a-7c, 8a-8c, and 9a-9c General procedure: Ultrasonication methodA mixture of 4, 5, or 6 (1.0 mmol), arylsulfonylacetic acid(1.0 mmol), and 3 cm3 phosphorus oxychloride was subjectedto ultrasound irradiation at a frequency of 35 kHzfor 30-50 min at 45 C. After completion of the reaction,the excess phosphorus oxychloride was removed under reduced pressure and the residue was poured onto crushedice. The separated solid was collected by filtration. It waswashed with saturated sodium bicarbonate solution followedby water, dried, and purified by column chromatography(silica gel 60-120 mesh) using ethyl acetatehexane(1:3) as eluent.2-[5-(Furan-2-yl)-1H-pyrazol-3-yl]-5-(tosylmethyl)-1,3,4-oxadiazole(7a, C17H14N4O4S) White solid (0.33 g, 91%);m.p.: 176-178 C; 1H NMR (DMSO-d6): d = 2.55 (s, 3H,Ar-CH3), 4.15 (s, 2H, CH2), 6.69-8.07 (m, 8H, Ar-H),11.74 (bs, 1H, pyrazole-NH) ppm; 13C NMR (DMSO-d6):d = 21.4 (Ar-CH3), 59.1 (CH2), 104.2, 107.8, 114.3, 126.8,131.2, 132.3, 134.3, 138.4, 141.5, 145.7, 156.8, 160.6,162.5 ppm; IR (KBr): m = 1145, 1334 (SO2), 1565 (C=N),1600 (C=C), 3242 (NH) cm-1; HRMS: m/z = 393.3736([M?Na]+). |