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Chemical Structure| 923565-73-5 Chemical Structure| 923565-73-5

Structure of 923565-73-5

Chemical Structure| 923565-73-5

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Product Details of [ 923565-73-5 ]

CAS No. :923565-73-5
Formula : C19H28N2O4
M.W : 348.44
SMILES Code : O=C(O)CC1=CC=C(CN2C[C@H](C)N(C(OC(C)(C)C)=O)CC2)C=C1

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Application In Synthesis of [ 923565-73-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 923565-73-5 ]

[ 923565-73-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 923565-73-5 ]
  • [ 923565-91-7 ]
  • [ 923565-74-6 ]
YieldReaction ConditionsOperation in experiment
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20.0℃; Description 19: 1,1-Dimethylethyl (2S)-4-[4-(2-{4-[(3-fluorophenyl)amino]-1-piperidinyl}-2-oxo- ethyl)phenyl]methyl}-2-methyl-1-piperazinecarboxylate (D19). A mixture of D18 (27.8g, 79.8mmol), /V-p^dimethylaminot°ropylJ-Lambda/1- ethylcarbodiimide hydrochloride (22.9g, 119.7mmol), 1-hydroxybenzotriazole hydrate (16.2g, 119.7mmol), triethylamine (45ml, 319.1mmol) and D56b hydrochloride salt (18.4g, 79.8mmol) in dry DMF (400ml) was stirred at room temperature overnight. The solvent was removed in vacuo and the residue re-dissolved in DCM (300ml), washed with 2M NaOH (2x200ml), water (200ml) and brine (200ml). All aqueous washings were combined and back extracted with DCM (2x100ml). The combined organics were dried and concentrated to give a solid which was purified by chromatography (silica pre-washed with 50% EtOAc/hexane). Elution with 70% EtOAc/hexane gave the title compound as a white solid (34.95g). deltaH (CDCI3, 400MHz) 7.28 (2H, d), 7.19 (2H, d), 7.07 (1 H, t), 6.23-6.40 (3H, m), 4.52 (1H, m), 4.17 (1 H, m), 3.78-3.88 (2H, m), 3.74 (2H, s), 3.60 (1 H, d), 3.40 (1 H, d), 3.43 (1 H, m), 3.38 (1 H, d), 3.06-3.17 (2H1 m), 2.89 (1H, m), 2.74 (1 H, m), 2.57 (1H, m), 1.94- EPO <DP n="39"/>2.13 (4H, m), 1.45 (9H1 s), 1.32 (1 H, m), 1.21 (3H, d), 1.09 (1H, m). MS (ES) MH+ 525.
 

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