Home Cart Sign in  
Chemical Structure| 92692-39-2 Chemical Structure| 92692-39-2

Structure of Amorphadiene
CAS No.: 92692-39-2

Chemical Structure| 92692-39-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Product Citations

Sarkar, Ankur ; Kim, Edward Y. ; Jang, Taehwan ; Hongdusit, Akarawin ; Kim, Hyungjun ; Choi, Jeong-Mo , et al.

Abstract: The design of small mols. that inhibit disease-relevant proteins represents a longstanding challenge of medicinal chem. Here, the authors describe an approach for encoding this challenge-the inhibition of a human drug target-into a microbial host and using it to guide the discovery and biosynthesis of targeted, biol. active natural products. This approach identified two previously unknown terpenoid inhibitors of protein tyrosine phosphatase 1B (PTP1B), an elusive therapeutic target for the treatment of diabetes and cancer. Both inhibitors appear to target an allosteric site, which confers selectivity, and can inhibit PTP1B in living cells. A screen of 24 uncharacterized terpene synthases from a pool of 4464 genes uncovered addnl. hits, demonstrating a scalable discovery approach, and the incorporation of different PTPs into the microbial host yielded alternative PTP-specific detection systems. Findings illustrate the potential for using microbes to discover and build natural products that exhibit precisely defined biochem. activities yet possess unanticipated structures and/or binding sites.

Keywords: PTP1B ; allostery ; biological selection ; natural products ; phosphatases ; terpene synthases

Purchased from AmBeed:

Alternative Products

Product Details of [ Amorphadiene ]

CAS No. :92692-39-2
Formula : C15H24
M.W : 204.35
SMILES Code : C=C([C@@H]1CC[C@@H](C)[C@]2([H])CCC(C)=C[C@]12[H])C
MDL No. :N/A
InChI Key :HMTAHNDPLDKYJT-CBBWQLFWSA-N
Pubchem ID :11052747

Safety of [ Amorphadiene ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

 

Historical Records

Categories