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Chemical Structure| 927672-81-9 Chemical Structure| 927672-81-9

Structure of 927672-81-9

Chemical Structure| 927672-81-9

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Product Details of [ 927672-81-9 ]

CAS No. :927672-81-9
Formula : C10H16N2O
M.W : 180.25
SMILES Code : NC1=CC=C(CN(C)C)C=C1OC
MDL No. :MFCD20723741

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Application In Synthesis of [ 927672-81-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 927672-81-9 ]

[ 927672-81-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 927672-81-9 ]
  • [ 1197953-49-3 ]
  • 5-chloro-N4-(2-(dimethylphosphoryl)phenyl)-N2-(2-methoxy-4-(1-(dimethylamino)methyl)phenyl)pyrimidine-2,4-diamine [ No CAS ]
YieldReaction ConditionsOperation in experiment
49.5% With hydrogenchloride; In 2-methoxy-ethanol; isopropyl alcohol; at 120℃;Inert atmosphere; 25mL with magnetic stirring and condenserCompound 6 (80 mg, 0.44 mmol) and Compound 7 (138 mg, 0.44 mmol) were added to a single vial.And ethylene glycol monomethyl ether (3mL),Stir and dissolve,Adding hydrogen chloride in isopropanol solution(0.66mmol, 0.13mL, 5M),The temperature was raised to 120 C under a nitrogen atmosphere and stirred to react overnight. Cool to room temperature,Add water (10 mL) and saturated sodium bicarbonate (5 mL).Extracted with dichloromethane (15mLx3),Combine the organic phase,Washed with saturated saline,Dry over anhydrous sodium sulfate,filter,concentrate,The residue was passed through a silica gel column to give a white solid.The yield was 49.5%.
 

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